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anti-CD31 antibody :: Mouse CD31 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210658
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD31, Monoclonal Antibody

 Also Known As   

MOUSE ANTI RAT CD31:FITC

 Product Gene Name   

anti-CD31 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q3SWT0
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    TLD-3A12
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD31 antibody

   Mouse anti Rat CD31 antibody, clone TLD-3A12 recognizes rat PECAM-1 (CD31), a 661 amino acid type 1 transmembrane protein expressed primarily on endothelial cells, platelets and leucocytes. Clone TLD-3A12 has been shown to partially block the proliferative response of antigen-specific CD4+ T cells to antigen-presenting cells and relevant antigen (Stevenson, K.S. et al.2009). This clone has been reported as suitable for use in IHC on formalin-fixed paraffin-embedded sections pre-treated with 0.2M boric acid, pH7.0. (Wilson et al. 2007). Mouse anti Rat CD31, clone TLD-3A12 has been shown to be cross-reactive with endothelial cells derived from rhesus macaque (Maclean et al. 2001)
 Applications Tested/Suitable for anti-CD31 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD31 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD31 antibody    Immunohistochemical staining of rat spleen cryosection with Mouse anti Rat CD31 (MBS212104)
anti-CD31 antibody Testing Data image
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 Testing Data of anti-CD31 antibody    Immunohistochemical staining of rat brain cryosection with Mouse anti Rat CD31 (MBS212105)
anti-CD31 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD31. It may not necessarily be applicable to this product.
 NCBI GI #    75832033
 NCBI GeneID    29583
 NCBI Accession #    NP_113779.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031591.1 [Other Products]
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 UniProt Primary Accession #    Q3SWT0 [Other Products]
 UniProt Secondary Accession #    P97635 [Other Products]
 UniProt Related Accession #    Q3SWT0 [Other Products]
 Molecular Weight    76,189 Da
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 NCBI Official Full Name    platelet endothelial cell adhesion molecule
 NCBI Official Synonym Full Names    platelet/endothelial cell adhesion molecule 1
 NCBI Official Symbol    Pecam1 [Similar Products]
 NCBI Official Synonym Symbols   
CD31; Pecam
[Similar Products]
 NCBI Protein Information    platelet endothelial cell adhesion molecule; PECAM-1
 UniProt Protein Name    Platelet endothelial cell adhesion molecule
 UniProt Synonym Protein Names   
CD_antigen: CD31
 UniProt Gene Name    Pecam1 [Similar Products]
 UniProt Synonym Gene Names    Pecam; PECAM-1 [Similar Products]
 UniProt Entry Name    PECA1_RAT
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 NCBI Summary for CD31    cell adhesion molecule, also intracellular signaling molecule; may mediate leukocyte adhesion and migration, angiogenesis, and thrombosis [RGD, Feb 2006]
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 UniProt Comments for CD31    PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Membrane protein, integral; Cell adhesion; G protein, monomeric, non-Rab; Cell surface; Contractile; Motility/polarity/chemotaxis; Vesicle

Cellular Component: extracellular space; cell surface; smooth muscle contractile fiber; membrane; plasma membrane; integral to membrane; intracellular; cell junction; external side of plasma membrane; lipid raft

Molecular Function: protein binding

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; wound healing; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of actin filament polymerization; response to cytokine stimulus; diapedesis; positive regulation of leukocyte migration; cell adhesion; regulation of cell migration; phagocytosis; Rho protein signal transduction
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 Research Articles on CD31    1. Shock wave therapy leads to mobilization of endogenous CD31/CD34-positive endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD31 antibodyDiseases associated with anti-CD31 antibody
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >635 publications with CD31 and Cardiovascular Diseases
 Inflammation Antibodies  >511 publications with CD31 and Inflammation
 Necrosis Antibodies  >406 publications with CD31 and Necrosis
 Neoplasms, Experimental Antibodies  >264 publications with CD31 and Neoplasms, Experimental
 Lung Diseases Antibodies  >247 publications with CD31 and Lung Diseases
 Heart Diseases Antibodies  >235 publications with CD31 and Heart Diseases
 Breast Neoplasms Antibodies  >209 publications with CD31 and Breast Neoplasms
 Lung Neoplasms Antibodies  >193 publications with CD31 and Lung Neoplasms
 Liver Diseases Antibodies  >181 publications with CD31 and Liver Diseases
 Liver Neoplasms Antibodies  >157 publications with CD31 and Liver Neoplasms
Organs/Tissues associated with anti-CD31 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >512 publications with CD31 and Embryonic Tissue
 Artery Antibodies  >483 publications with CD31 and Artery
 Lung Antibodies  >443 publications with CD31 and Lung
 Heart Antibodies  >359 publications with CD31 and Heart
 Brain Antibodies  >325 publications with CD31 and Brain
 Eye Antibodies  >184 publications with CD31 and Eye
 Placenta Antibodies  >109 publications with CD31 and Placenta
 Spleen Antibodies  >101 publications with CD31 and Spleen
 Prostate Antibodies  >88 publications with CD31 and Prostate
 Pancreas Antibodies  >62 publications with CD31 and Pancreas
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