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anti-CR1 antibody :: Mouse anti-Human CD35 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8209536
Flow Cytometry (FC/FACS)
Unit / Price
50 Assays  /  $215 +1 FREE 8GB USB
100 Assays  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD35 (CR1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-CD35 Antibody-FITC labled

 Product Synonym Names    C3BR; Complement receptor type 1; C3b/C4b receptor; CD antigen CD35
 Product Gene Name   

anti-CR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120620
 3D Structure    ModBase 3D Structure for P17927
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognises human CD35.
 Purity/Purification    The antibody was purified by affinity chromatography.
 Form/Format    Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.
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 Conjugation    FITC
 Directions for Use    1. Take 100 ul peripheral blood anticoagulated by EDTA and add to the bottom of 5 ml tube.
2. Add 10 ul labeled antibody to the bottom of flow tube mixing with the whole blood, incubate for 20 minutes at room temperature away from light.
3. Add 2 ml RBC lysis buffer, incubate for 10 minutes away from light after mixing, dissolve red blood cells.
4. Sample tube is set to 1000 rpm centrifugation for 5 minutes, discard the supernatant.
5. Add 2 ml PBS wash buffer to resuspend the cells, then 1000 rpm centrifugation for 5 minutes, discard the supernatant.
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 Preparation and Storage    Shipped and store at 4 degree C for one year. Do not freeze.
 Other Notes    Small volumes of anti-CR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CR1 antibody

   Mouse monoclonal antibody to CD35 (FITC)
 Applications Tested/Suitable for anti-CR1 antibody   

Immunofluoresence (IF), Flow Cytometry (FC/FACS)

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 Flow Cytometry (FC/FACS) of anti-CR1 antibody    Flow cytometric analysis of human peripheral blood granulocytes using Anti-CD35 Antibody-FITC labled.
anti-CR1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CR1. It may not necessarily be applicable to this product.
 NCBI GI #    86793036
 NCBI GeneID    1378
 NCBI Accession #    NP_000564.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000573.3 [Other Products]
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 UniProt Primary Accession #    P17927 [Other Products]
 UniProt Secondary Accession #    Q16744; Q16745; Q5SR43; Q5SR45; Q9UQV2 [Other Products]
 UniProt Related Accession #    P17927 [Other Products]
 Molecular Weight    223,663 Da
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 NCBI Official Full Name    complement receptor type 1 isoform F
 NCBI Official Synonym Full Names    complement component (3b/4b) receptor 1 (Knops blood group)
 NCBI Official Symbol    CR1 [Similar Products]
 NCBI Official Synonym Symbols   
KN; C3BR; C4BR; CD35
[Similar Products]
 NCBI Protein Information    complement receptor type 1
 UniProt Protein Name    Complement receptor type 1
 UniProt Synonym Protein Names   
C3b/C4b receptor; CD_antigen: CD35
 Protein Family    Complement receptor
 UniProt Gene Name    CR1 [Similar Products]
 UniProt Synonym Gene Names    C3BR [Similar Products]
 UniProt Entry Name    CR1_HUMAN
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 NCBI Summary for CR1    This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CR1    CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; complement component C3b binding

Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway

Disease: Knops Blood Group System; Malaria, Susceptibility To
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 Research Articles on CR1    1. THE COMBINATION OF EXPRESSION OF MARKERS CR1 AND CR2 (CD35/CD21) IN DIAGNOSTIC OF B-CELL LYMPHOPROLIFERATIVE DISEASES
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CR1 antibodyPathways associated with anti-CR1 antibody
 Reference Product  PubMed Publications
 CR2 antibody  >584 publications with CR1 and CR2
 C4B antibody  >223 publications with CR1 and C4B
 CD46 antibody  >74 publications with CR1 and CD46
 C4A antibody  >13 publications with CR1 and C4A
 IL8 antibody  >4 publications with CR1 and IL8
 CFI antibody  >3 publications with CR1 and CFI
 CDC42 antibody  >1 publications with CR1 and CDC42
 C5AR1 antibody  >1 publications with CR1 and C5AR1
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
Diseases associated with anti-CR1 antibodyOrgans/Tissues associated with anti-CR1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >182 publications with CR1 and Inflammation
 Nervous System Diseases Antibodies  >159 publications with CR1 and Nervous System Diseases
 Alzheimer Disease Antibodies  >103 publications with CR1 and Alzheimer Disease
 Kidney Diseases Antibodies  >85 publications with CR1 and Kidney Diseases
 Necrosis Antibodies  >72 publications with CR1 and Necrosis
 Respiratory Tract Diseases Antibodies  >70 publications with CR1 and Respiratory Tract Diseases
 Malaria Antibodies  >67 publications with CR1 and Malaria
 Malaria, Falciparum Antibodies  >55 publications with CR1 and Malaria, Falciparum
 Chromosome Aberrations Antibodies  >50 publications with CR1 and Chromosome Aberrations
 Liver Diseases Antibodies  >50 publications with CR1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1551 publications with CR1 and Blood
 Vascular Antibodies  >91 publications with CR1 and Vascular
 Lymph Node Antibodies  >61 publications with CR1 and Lymph Node
 Lymph Antibodies  >42 publications with CR1 and Lymph
 Intestine Antibodies  >30 publications with CR1 and Intestine
 Nerve Antibodies  >27 publications with CR1 and Nerve
 Connective Tissue Antibodies  >15 publications with CR1 and Connective Tissue
 Uterus Antibodies  >8 publications with CR1 and Uterus
 Mouth Antibodies  >4 publications with CR1 and Mouth
 Placenta Antibodies  >3 publications with CR1 and Placenta
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