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anti-CD36 antibody :: Mouse CD36 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210263
Unit / Price
1 mg  /  $960 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD36, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD36:Preservative Free

 Product Gene Name   

anti-CD36 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173510
 3D Structure    ModBase 3D Structure for P16671
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    SMØ
 Host    Mouse
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 Form/Format    Preservative Free
Purified IgM - liquid
 Concentration    IgM concentration 1 mg/ml (lot specific)
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 Preparation    Purified IgM prepared by ammonium sulphate precipitation from tissue culture supernatant
 Immunogen    Human tonsil cells and peripheral blood mononuclear cells.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at -20o only. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD36 antibody

   Mouse anti Human CD36 antibody, clone SM˜ recognizes the CD36 antigen, an 88kD cell surface glycoprotein expressed by platelets, monocytes/macrophages and also by some microvascular endothelium and erythroid precursors. CD36 is the receptor for thrombospondin. When expressed by monocytes and macrophages, CD36 acts as a receptor for oxidized LDL and for apoptotic polymorphonuclear cells. Mouse anti Human CD36 antibody, clone SM˜ partially inhibits collagen induced platelet aggregation and macrophage ingestion of apoptotic human neutrophils. It has been reported that this antibody may activate platelets as measured by fibrinogen binding, P-Selectin expression and Annexin V binding - for further details please contact our Technical Services team. Mouse anti Human CD36 antibody, clone SM˜ is also reported to block interaction of oxidised low-density lipoprotein (OXLDL) with CD36 (Sugihara et al.1992).
 Applications Tested/Suitable for anti-CD36 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Functional Assays (FN)

 Application Notes for anti-CD36 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50
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 Testing Data of anti-CD36 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD36 antibody, clone SMø (MBS213128) followed by the HISTAR detection system . Medium power
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD36 antibody, clone SMø (MBS213128) followed by the HISTAR detection system . Low power
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD36: Alexa Fluor 647 (MBS213128A647)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD36: Azide Free
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD36: FITC (MBS211078)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Immunoperoxidase staining of human tonsil cryosection with Mouse anti Human CD36 antibody, clone SMø (MBS213128) followed by the HISTAR detection system . High power SMθ
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of human peripheral blood platelets with Mouse anti Human CD36 (MBS213128)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of human peripheral blood platelets with Mouse anti Human CD36 (MBS213129)
anti-CD36 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
 NCBI GI #    48375178
 NCBI GeneID    948
 NCBI Accession #    NP_000063.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000072.3 [Other Products]
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 UniProt Primary Accession #    P16671 [Other Products]
 UniProt Secondary Accession #    Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; D9IX66; D9IX67; D9IX68; D9IX69 [Other Products]
 UniProt Related Accession #    P16671 [Other Products]
 Molecular Weight    46,090 Da
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 NCBI Official Full Name    platelet glycoprotein 4 isoform 1
 NCBI Official Synonym Full Names    CD36 molecule (thrombospondin receptor)
 NCBI Official Symbol    CD36 [Similar Products]
 NCBI Official Synonym Symbols   
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
[Similar Products]
 NCBI Protein Information    platelet glycoprotein 4; CD36 antigen (collagen type I receptor, thrombospondin receptor); GPIIIB; PAS IV; PAS-4 protein; cluster determinant 36; fatty acid translocase; glycoprotein IIIb; leukocyte differentiation antigen CD36; platelet glycoprotein IV; scavenger receptor class B, member 3
 UniProt Protein Name    Platelet glycoprotein 4
 UniProt Synonym Protein Names   
Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD_antigen: CD36
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    CD36 [Similar Products]
 UniProt Synonym Gene Names    GP3B; GP4; FAT; GPIIIB; GPIV [Similar Products]
 UniProt Entry Name    CD36_HUMAN
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 NCBI Summary for CD36    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
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 UniProt Comments for CD36    CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft

Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding

Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; antigen processing and presentation of peptide antigen via MHC class I; sequestering of lipid; cell surface receptor linked signal transduction; platelet degranulation; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell adhesion; positive regulation of cell-matrix adhesion; toll-like receptor 4 signaling pathway; receptor-mediated endocytosis; platelet activation; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; blood coagulation; positive regulation of phagocytosis, engulfment; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; apoptotic cell clearance

Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To
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 Research Articles on CD36    1. These findings suggest that oxidized HDL enhances the pro-inflammatory properties and impairs the function of HK-2 cells, mainly through the scavenger receptor, CD36, as well as through the Src, MAPK and NF-kappaB pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD36 antibodyDiseases associated with anti-CD36 antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >769 publications with CD36 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >751 publications with CD36 and Atherosclerosis
 Inflammation Antibodies  >494 publications with CD36 and Inflammation
 Insulin Resistance Antibodies  >321 publications with CD36 and Insulin Resistance
 Fatty Liver Antibodies  >315 publications with CD36 and Fatty Liver
 Malaria Antibodies  >311 publications with CD36 and Malaria
 Necrosis Antibodies  >276 publications with CD36 and Necrosis
 Liver Diseases Antibodies  >212 publications with CD36 and Liver Diseases
 Heart Diseases Antibodies  >171 publications with CD36 and Heart Diseases
 Hyperlipidemias Antibodies  >114 publications with CD36 and Hyperlipidemias
Organs/Tissues associated with anti-CD36 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1980 publications with CD36 and Blood
 Vascular Antibodies  >696 publications with CD36 and Vascular
 Liver Antibodies  >671 publications with CD36 and Liver
 Muscle Antibodies  >656 publications with CD36 and Muscle
 Heart Antibodies  >388 publications with CD36 and Heart
 Adipose Tissue Antibodies  >283 publications with CD36 and Adipose Tissue
 Bone Antibodies  >217 publications with CD36 and Bone
 Brain Antibodies  >213 publications with CD36 and Brain
 Connective Tissue Antibodies  >211 publications with CD36 and Connective Tissue
 Bone Marrow Antibodies  >195 publications with CD36 and Bone Marrow
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