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anti-CD36 antibody :: Rat CD36 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219350
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD36, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD36:FITC

 Product Gene Name   

anti-CD36 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q08857
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    MF3
 Host    Rat
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Preparation
 Immunogen    IL-4 treated murine thioglycollate-elicited peritoneal macrophages.
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD36 antibody

   Rat anti Mouse CD36 antibody, clone MF3 recognizes mouse CD36, an 85kD transmembrane glycoprotein which is primarily expressed on platelets, monocytes/macrophages, smooth muscle and endothelial cells. The CD36 molecule is type B scavenger receptor, which binds to multiple ligands including thrombospondin, anionic phospholipids, oxidized low density lipoproteins and long chain fatty acids. CD36 has diverse functions and is reported to play a role in innate immunity, platelet adhesion/aggregation and long chain fatty acid transport. The CD36 molecule also directly mediates cytoadhesion of erythrocytes infected with Plasmodium falciparum, and may be involved in the development of atherosclerotic lesions and the formation of foam cells. Rat anti Mouse CD36 antibody, clone MF3 has been shown to inhibit IL-4 induced thioglycollate-elicited peritoneal macrophage fusion and significantly block IL-4/GM-CSF-induced bone-marrorw derived macrophage fusion.
 Applications Tested/Suitable for anti-CD36 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD36 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD36 antibody    Staining of Mouse peripheral blood platelets with Rat anti Mouse CD36:Alexa Fluor ?647 (MBS217380A647)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of mouse peripheral blood platelets with Rat anti Mouse CD36 (MBS217382)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of Mouse peripheral blood platelets with Rat anti Mouse CD36 Alexa Fluor 488 (MBS217380A488)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of mouse peripheral blood platelets with Rat anti Mouse CD36:Low Endotoxin (MBS217381)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of mouse peripheral blood platelets with Rat anti Mouse CD36 (MBS217380)
anti-CD36 antibody Testing Data image
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 Testing Data of anti-CD36 antibody    Staining of mouse peripheral blood platelets with Rat anti Mouse CD36:FITC
anti-CD36 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
 NCBI GI #    227116347
 NCBI GeneID    12491
 NCBI Accession #    NP_001153027.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001159555.1 [Other Products]
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 UniProt Primary Accession #    Q08857 [Other Products]
 UniProt Related Accession #    Q08857 [Other Products]
 Molecular Weight    52,698 Da
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 NCBI Official Full Name    platelet glycoprotein 4
 NCBI Official Synonym Full Names    CD36 antigen
 NCBI Official Symbol    Cd36 [Similar Products]
 NCBI Official Synonym Symbols   
FAT; GPIV; Scarb3
[Similar Products]
 NCBI Protein Information    platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4; fatty acid translocase; glycoprotein IIIb; platelet glycoprotein IV
 UniProt Protein Name    Platelet glycoprotein 4
 UniProt Synonym Protein Names   
Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein IV; GPIV; CD_antigen: CD36
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    Cd36 [Similar Products]
 UniProt Synonym Gene Names    GPIIIB; GPIV [Similar Products]
 UniProt Entry Name    CD36_MOUSE
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 UniProt Comments for CD36    CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion

Cellular Component: Golgi apparatus; extracellular space; protein complex; cell surface; intracellular membrane-bound organelle; mitochondrion; endoplasmic reticulum; integral to membrane; caveola; lipid raft; membrane; apical part of cell; plasma membrane; intracellular; sarcolemma; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding; low-density lipoprotein binding; lipid binding; high-density lipoprotein binding

Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; pattern recognition receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription factor import into nucleus; fatty acid metabolic process; signal transduction; low density lipoprotein mediated signaling; sequestering of lipid; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; transport; cell adhesion; positive regulation of cell-matrix adhesion; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; long-chain fatty acid transport; receptor-mediated endocytosis; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of systemic arterial blood pressure; positive regulation of interleukin-6 production; long-chain fatty acid metabolic process; positive regulation of tumor necrosis factor production; negative regulation of angiogenesis; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; triacylglycerol metabolic process; response to mechanical stimulus; lipoprotein transport; fatty acid oxidation; positive regulation of phagocytosis, engulfment; nitric oxide mediated signal transduction; plasma membrane long-chain fatty acid transport; apoptotic cell clearance; fatty acid transport; positive regulation of cytokine secretion
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 Research Articles on CD36    1. Enhanced CD36-mediated hepatic fat uptake may contribute to an accelerated progression of nonalcoholic fatty liver disease in mice and humans
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD36 antibodyDiseases associated with anti-CD36 antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >769 publications with CD36 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >751 publications with CD36 and Atherosclerosis
 Inflammation Antibodies  >494 publications with CD36 and Inflammation
 Insulin Resistance Antibodies  >321 publications with CD36 and Insulin Resistance
 Fatty Liver Antibodies  >315 publications with CD36 and Fatty Liver
 Malaria Antibodies  >311 publications with CD36 and Malaria
 Necrosis Antibodies  >276 publications with CD36 and Necrosis
 Liver Diseases Antibodies  >212 publications with CD36 and Liver Diseases
 Heart Diseases Antibodies  >171 publications with CD36 and Heart Diseases
 Hyperlipidemias Antibodies  >114 publications with CD36 and Hyperlipidemias
Organs/Tissues associated with anti-CD36 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1980 publications with CD36 and Blood
 Liver Antibodies  >671 publications with CD36 and Liver
 Heart Antibodies  >388 publications with CD36 and Heart
 Artery Antibodies  >265 publications with CD36 and Artery
 Bone Antibodies  >217 publications with CD36 and Bone
 Brain Antibodies  >213 publications with CD36 and Brain
 Bone Marrow Antibodies  >195 publications with CD36 and Bone Marrow
 Skin Antibodies  >160 publications with CD36 and Skin
 Kidney Antibodies  >144 publications with CD36 and Kidney
 Lung Antibodies  >133 publications with CD36 and Lung
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