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anti-CD36 antibody :: anti-Human CD36 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311750 anti-CD36 antibody
Unit / Price
0.2 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD36, Monoclonal Antibody

 Also Known As   

MAb to CD36

 Product Synonym Names    Monoclonal Antibody to Human CD36
 Product Gene Name   

anti-CD36 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (80231504..80308593). Location: 7q11.2
 OMIM    173510
 3D Structure    ModBase 3D Structure for P16671
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    289-10930 (SM?)
 Host    Host: Mouse
Source: Tissue Culture
 Species Reactivity    Human
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 Specificity    CD36
Human CD36
 Purity/Purification    >90% pure (SDS-PAGE). S-300 Sepharose size exclusion chromatography.
 Form/Format    Purified, Liquid
 Concentration    1.0mg/ml (OD280nm, E^0.1% = 1.2) (lot specific)
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 Immunogen    Human tonsil cells and PBM
 Affinity Constant    Not determined
 Buffer    10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    0.1% Sodium Azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short-term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD36 antibody    Monoclonal Antibodies to Human CDs
NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
 NCBI GI #    525233
 NCBI GeneID    948
 NCBI Accession #    CAA83662.1 [Other Products]
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 UniProt Primary Accession #    P16671 [Other Products]
 UniProt Secondary Accession #    Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; Q9BZN4; Q9BZN5 [Other Products]
 UniProt Related Accession #    P16671; Q13965; Q9BQA7; Q9BZM7; Q9BZM9; Q9BZN0; Q9BZN1; Q9BZN2; Q9BZN6 [Other Products]
 Molecular Weight    53,053 Da [Similar Products]
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 NCBI Official Full Name    CD36
 NCBI Official Synonym Full Names    CD36 molecule (thrombospondin receptor)
 NCBI Official Symbol    CD36 [Similar Products]
 NCBI Official Synonym Symbols   
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3
[Similar Products]
 NCBI Protein Information    platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)
 UniProt Protein Name    Platelet glycoprotein 4
 UniProt Synonym Protein Names   
Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    CD36 [Similar Products]
 UniProt Synonym Gene Names    GP3B; GP4 [Similar Products]
 UniProt Entry Name    CD36_HUMAN
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 NCBI Summary for CD36    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
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 UniProt Comments for CD36    Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22

Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12

Subcellular location: Membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16

Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection.

Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[

MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [

MIM:610938]. Ref.23

Sequence similarities: Belongs to the CD36 family.

Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.
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Product References and Citations for anti-CD36 antibody

   • Hogg, N.H. et al (1984) Immunology 53:753
• Linch, D.C et al (1984) Blood 63:566
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 Research Articles on CD36    1. These results suggested that type I CD36 deficiency but not type II CD36 deficiency predisposes preschool children to hypoglycemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD36 antibodyPathways associated with anti-CD36 antibody
 Reference Product  PubMed Publications
 THBS1 antibody  >147 publications with CD36 and THBS1
 SRC antibody  >45 publications with CD36 and SRC
 CD9 antibody  >34 publications with CD36 and CD9
 FYN antibody  >18 publications with CD36 and FYN
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Collagen Adhesion Via Gp IV Pathway antibodies  Collagen Adhesion Via Gp IV Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD36 antibodyOrgans/Tissues associated with anti-CD36 antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >527 publications with CD36 and Atherosclerosis
 Arteriosclerosis Antibodies  >346 publications with CD36 and Arteriosclerosis
 Neoplasms Antibodies  >316 publications with CD36 and Neoplasms
 Inflammation Antibodies  >292 publications with CD36 and Inflammation
 PLATELET GLYCOPROTEIN IV DEFICIENCY Antibodies  >285 publications with CD36 and PLATELET GLYCOPROTEIN IV DEFICIENCY
 Malaria Antibodies  >263 publications with CD36 and Malaria
 Insulin Resistance Antibodies  >211 publications with CD36 and Insulin Resistance
 Obesity Antibodies  >188 publications with CD36 and Obesity
 Fatty Liver Antibodies  >168 publications with CD36 and Fatty Liver
 Hematologic Diseases Antibodies  >162 publications with CD36 and Hematologic Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1530 publications with CD36 and Blood
 Vascular Antibodies  >544 publications with CD36 and Vascular
 Muscle Antibodies  >480 publications with CD36 and Muscle
 Liver Antibodies  >435 publications with CD36 and Liver
 Heart Antibodies  >281 publications with CD36 and Heart
 Adipose Tissue Antibodies  >159 publications with CD36 and Adipose Tissue
 Bone Antibodies  >159 publications with CD36 and Bone
 Brain Antibodies  >144 publications with CD36 and Brain
 Bone Marrow Antibodies  >144 publications with CD36 and Bone Marrow
 Skin Antibodies  >138 publications with CD36 and Skin
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