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anti-CD36 antibody :: Mouse anti-Human CD36 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570327 anti-CD36 antibody
Unit / Price
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD36, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse anti Human CD36

 Product Gene Name   

anti-CD36 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 611162
 3D Structure    ModBase 3D Structure for P16671
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    185-1G2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The mouse monoclonal antibody 185-1G2 recognises human CD36. The antibody recognises an epitope between amino acids 155 - 183 on the CD36
 Form/Format    Each vial contains 100ul 1mg/ml purified monoclonal antibody in phosphate buffered saline (PBS) containing 0.09% sodium azide. This product is lyophilized
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 Source Note    185-1G2 is a mouse monoclonal IgG2a antibody derived by fusion of NS1 mouse myeloma cells with spleen cells from BALB/c mice immunized with stimulated human leucocytes.
 Product    Primary Antibodies
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD36 antibody

   The CD36 molecule is an 88kDa transmembrane glycoprotein, which is a member of the class B scavenger receptor family of proteins. Alternative names for CD36 include fatty acid translocase (FAT), platelet glycoprotein 4, platelet glycoprotein IIIb and thrombospondin receptor. CD36 is a pattern recognition receptor that is expressed on a wide variety of cells including monocytes, macrophages, platelets, adipocytes, erythrocyte precursors, activated keratinocytes and some endothelial and epithelial cells. Studies suggest that CD36 has multiple cellular functions and binds to a diverse array of ligands including thrombospondin, modified low-density lipoproteins (LDL), anionic phospholipids and long chain fatty acids.
As a scavenger receptor, CD36 plays a key role in mediating the uptake of oxidized LDL by macrophages, the formation of foam cells and the development of atherosclerosis. CD36 is also reported to function as negative regulator of angiogenesis, as a cell adhesion molecule involved in platelet adhesion and aggregation, and as a scavenger receptor in the clearance of apoptotic cells and photoreceptor rod outer segments. Furthermore, CD36 is reported to bind to Plasmodium falciparum infected erythrocytes and may play an important role in the pathogenesis of malaria and sickle cell disease.
 Product Categories/Family for anti-CD36 antibody    Immunology, Cell Adhesion
 Applications Tested/Suitable for anti-CD36 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin, Flow Cytometry (FC/FACS)

 Application Notes for anti-CD36 antibody    The antibody 185-1G2 can be used for CD36 cell identification, quantification and isolation using flow cytometric methods. The antibody is suitable for use in immunocytochemistry and immunohistochemistry on frozen tissue sections.

The antibody has also been reported to bind to a site of CD36 that inhibits CD36 function. For this application, please request a sodium azide free antibody format.

Optimal antibody dilutions for the different applications should be determined by titration. The recommended range for flow cytometry is 1:100 - 1:200.
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NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
 NCBI GI #    48375178
 NCBI GeneID    948
 NCBI Accession #    NP_000063.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000072.3 [Other Products]
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 UniProt Primary Accession #    P16671 [Other Products]
 UniProt Secondary Accession #    Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; D9IX66; D9IX67; D9IX68; D9IX69 [Other Products]
 UniProt Related Accession #    P16671 [Other Products]
 Molecular Weight    46,090 Da
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 NCBI Official Full Name    platelet glycoprotein 4 isoform 1
 NCBI Official Synonym Full Names    CD36 molecule (thrombospondin receptor)
 NCBI Official Symbol    CD36 [Similar Products]
 NCBI Official Synonym Symbols   
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
[Similar Products]
 NCBI Protein Information    platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)
 UniProt Protein Name    Platelet glycoprotein 4
 UniProt Synonym Protein Names   
Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD_antigen: CD36
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    CD36 [Similar Products]
 UniProt Synonym Gene Names    GP3B; GP4; FAT; GPIIIB; GPIV [Similar Products]
 UniProt Entry Name    CD36_HUMAN
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 NCBI Summary for CD36    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
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 UniProt Comments for CD36    CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; external side of plasma membrane; lipid raft

Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding

Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; sequestering of lipid; antigen processing and presentation of peptide antigen via MHC class I; platelet degranulation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell adhesion; positive regulation of cell-matrix adhesion; toll-like receptor 4 signaling pathway; platelet activation; receptor-mediated endocytosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; cholesterol transport; positive regulation of interleukin-6 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; blood coagulation; positive regulation of phagocytosis, engulfment; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; apoptotic cell clearance

Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To
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Product References and Citations for anti-CD36 antibody

   1. Howard LM, Puente Navazo MD, McGregor JL. Identification of CD36-ractive antibodies that bind an epitope encompassing amino acid residues 155-183. In Leucocyte typing VI. Sixth International workshop and conference. Kishimoto T, Kikutani H, von dem Borne AEG.Kr, Goyert SA, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, Zola H. Eds. Kobe, Japan, Garland. 1996. p637-638.
2. Englyst NA, Taube JM, Aitman TJ, Baglin TP, Byrne CD. A novel role for CD36 in VLDL-enhanced platelet adhesion. Diabetes 2003; 52:1248 - 1255.
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 Research Articles on CD36    1. Enhanced CD36-mediated hepatic fat uptake may contribute to an accelerated progression of nonalcoholic fatty liver disease in mice and humans
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD36 antibodyDiseases associated with anti-CD36 antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >761 publications with CD36 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >744 publications with CD36 and Atherosclerosis
 Inflammation Antibodies  >490 publications with CD36 and Inflammation
 Insulin Resistance Antibodies  >320 publications with CD36 and Insulin Resistance
 Fatty Liver Antibodies  >310 publications with CD36 and Fatty Liver
 Malaria Antibodies  >310 publications with CD36 and Malaria
 Necrosis Antibodies  >273 publications with CD36 and Necrosis
 Liver Diseases Antibodies  >207 publications with CD36 and Liver Diseases
 Heart Diseases Antibodies  >168 publications with CD36 and Heart Diseases
 Dyslipidemias Antibodies  >139 publications with CD36 and Dyslipidemias
Organs/Tissues associated with anti-CD36 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1963 publications with CD36 and Blood
 Vascular Antibodies  >692 publications with CD36 and Vascular
 Liver Antibodies  >665 publications with CD36 and Liver
 Muscle Antibodies  >649 publications with CD36 and Muscle
 Heart Antibodies  >383 publications with CD36 and Heart
 Adipose Tissue Antibodies  >275 publications with CD36 and Adipose Tissue
 Bone Antibodies  >217 publications with CD36 and Bone
 Brain Antibodies  >212 publications with CD36 and Brain
 Connective Tissue Antibodies  >210 publications with CD36 and Connective Tissue
 Bone Marrow Antibodies  >195 publications with CD36 and Bone Marrow
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