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anti-CD36 antibody :: Mouse anti-Human CD36 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831317
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD36, Monoclonal Antibody

 Also Known As   

CD36 antibody

 Product Synonym Names    Monoclonal CD36; Anti-CD36; Cluster of Differentiation 36; FAT; SCARB3; GP88; glycoprotein IV; gpIV; glycoprotein IIIb; gpIIIb; CD36; CD 36; CD-36
 Product Gene Name   

anti-CD36 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173510
 3D Structure    ModBase 3D Structure for P16671
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4H7
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    CD36 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    CD36 is an integral membrane protein found on the surface of many cell types in vertebrate animals and is also known as FAT, SCARB3, GP88, glycoprotein IV (gpIV) and glycoprotein IIIb (gpIIIb). CD36 is a member of the class B scavenger receptor family of cell surface proteins. CD36 binds many ligands including collagen, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, oxidized low density lipoprotein, native lipoproteins, oxidized phospholipids, and long-chain fatty acids.
 Immunogen    CD36 antibody was raised in mouse using a full length recombinant protein of human CD36 (NP_000063) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD36 antibody

   Mouse monoclonal CD36 antibody
 Product Categories/Family for anti-CD36 antibody    Immunology
 Applications Tested/Suitable for anti-CD36 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-CD36 antibody    FC: 1:100
IF: 1:100
WB: 1:2000
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 Western Blot (WB) of anti-CD36 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant CD36 protein (Right) or empty vector (Left) detected with CD36 antibody
anti-CD36 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-CD36 antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant CD36 protein using CD36 antibody
anti-CD36 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for CD36. It may not necessarily be applicable to this product.
 NCBI GI #    48375178
 NCBI GeneID    948
 NCBI Accession #    NP_000063 [Other Products]
 NCBI GenBank Nucleotide #    NM_000072.3 [Other Products]
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 UniProt Primary Accession #    P16671 [Other Products]
 UniProt Secondary Accession #    Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; D9IX66; D9IX67; D9IX68; D9IX69 [Other Products]
 UniProt Related Accession #    P16671 [Other Products]
 Molecular Weight    46,090 Da
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 NCBI Official Full Name    platelet glycoprotein 4 isoform 1
 NCBI Official Synonym Full Names    CD36 molecule (thrombospondin receptor)
 NCBI Official Symbol    CD36 [Similar Products]
 NCBI Official Synonym Symbols   
FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10
[Similar Products]
 NCBI Protein Information    platelet glycoprotein 4
 UniProt Protein Name    Platelet glycoprotein 4
 UniProt Synonym Protein Names   
Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD_antigen: CD36
 Protein Family    Platelet glycoprotein
 UniProt Gene Name    CD36 [Similar Products]
 UniProt Synonym Gene Names    GP3B; GP4; FAT; GPIIIB; GPIV [Similar Products]
 UniProt Entry Name    CD36_HUMAN
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 NCBI Summary for CD36    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
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 UniProt Comments for CD36    CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: Golgi apparatus; extracellular space; platelet alpha granule membrane; cell surface; membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; transforming growth factor beta binding; low-density lipoprotein binding; lipid binding; high-density lipoprotein binding

Biological Process: positive regulation of blood coagulation; cGMP-mediated signaling; positive regulation of interleukin-12 production; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; sequestering of lipid; antigen processing and presentation of peptide antigen via MHC class I; cell surface receptor linked signal transduction; platelet degranulation; positive regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I; positive regulation of cell-matrix adhesion; cell adhesion; toll-like receptor 4 signaling pathway; receptor-mediated endocytosis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; cholesterol transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; lipoprotein transport; toll-like receptor signaling pathway; innate immune response; lipid metabolic process; blood coagulation; positive regulation of phagocytosis, engulfment; nitric oxide mediated signal transduction; plasma membrane long-chain fatty acid transport; apoptotic cell clearance

Disease: Platelet Glycoprotein Iv Deficiency; Coronary Heart Disease, Susceptibility To, 7; Malaria, Susceptibility To
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 Research Articles on CD36    1. CD36 SNP 1761667 may have a role in decreased lipid taste perception in obese Tunisian women
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD36 antibodyPathways associated with anti-CD36 antibody
 Reference Product  PubMed Publications
 PPARG antibody  >322 publications with CD36 and PPARG
 THBS1 antibody  >185 publications with CD36 and THBS1
 TLR2 antibody  >73 publications with CD36 and TLR2
 SRC antibody  >72 publications with CD36 and SRC
 FABP4 antibody  >43 publications with CD36 and FABP4
 CD9 antibody  >39 publications with CD36 and CD9
 FYN antibody  >24 publications with CD36 and FYN
 TLR6 antibody  >10 publications with CD36 and TLR6
 PPARA antibody  >5 publications with CD36 and PPARA
 GP5 antibody  >1 publications with CD36 and GP5
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
Diseases associated with anti-CD36 antibodyOrgans/Tissues associated with anti-CD36 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >794 publications with CD36 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >775 publications with CD36 and Atherosclerosis
 Inflammation Antibodies  >523 publications with CD36 and Inflammation
 Insulin Resistance Antibodies  >336 publications with CD36 and Insulin Resistance
 Fatty Liver Antibodies  >327 publications with CD36 and Fatty Liver
 Malaria Antibodies  >314 publications with CD36 and Malaria
 Necrosis Antibodies  >285 publications with CD36 and Necrosis
 Liver Diseases Antibodies  >219 publications with CD36 and Liver Diseases
 Heart Diseases Antibodies  >178 publications with CD36 and Heart Diseases
 Dyslipidemias Antibodies  >143 publications with CD36 and Dyslipidemias
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2028 publications with CD36 and Blood
 Vascular Antibodies  >711 publications with CD36 and Vascular
 Liver Antibodies  >692 publications with CD36 and Liver
 Muscle Antibodies  >673 publications with CD36 and Muscle
 Heart Antibodies  >405 publications with CD36 and Heart
 Adipose Tissue Antibodies  >300 publications with CD36 and Adipose Tissue
 Bone Antibodies  >227 publications with CD36 and Bone
 Brain Antibodies  >220 publications with CD36 and Brain
 Connective Tissue Antibodies  >217 publications with CD36 and Connective Tissue
 Bone Marrow Antibodies  >204 publications with CD36 and Bone Marrow
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