BAA18966.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,788 Da
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Synonym Symbols
NCBI Protein Information
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
UniProt Synonym Gene Names
UniProt Entry Name
CD38_HUMAN
NCBI Summary for CD38
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]
UniProt Comments for CD38
CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lyase; Apoptosis; Cell surface; Hydrolase; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.2.2.6; Membrane protein, integral; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4p15
Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus
Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity
Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; response to hydroperoxide; positive regulation of B cell proliferation; response to hypoxia; positive regulation of vasoconstriction; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; response to progesterone stimulus; negative regulation of apoptosis
Research Articles on CD38
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Products associated with anti-CD38 antibody
Pathways associated with anti-CD38 antibody
Diseases associated with anti-CD38 antibody
Organs/Tissues associated with anti-CD38 antibody
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