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anti-CD38 antibody :: Rat anti-Mouse CD38 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673345 anti-CD38 antibody
Unit / Price
0.5 mg  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD38, Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse CD38-UNLB

 Product Synonym Names    Rat Anti-Mouse CD38 - Purified, Unlabeled Antibody; Rat Anti-Mouse CD38
 Product Gene Name   

anti-CD38 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (15779931..15850706). Location: 4p15
 OMIM    107270
 3D Structure    ModBase 3D Structure for P28907
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 Clonality    Monoclonal
 Isotype    Rat IgG2a kappa
 Clone Number    90
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    CD38 (Mr 42-kDa), an immunoregulatory ectoenzyme
Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR).^1-3 It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice.^4 It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR alpha beta ^+, CD4^-, CD8^-.5, 6 Murine CD38 is also expressed by all Mac-1^+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages.^4, 7 Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.^2,5, 8
 Form/Format    Purified (UNLB) Antibody
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 Characterization    To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL or 0..2 mg in 2.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The allophycocyanin (APC) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD38 antibody   

Flow Cytometry; Immunohistochemistry (Frozen Sections); Immunoprecipitation

 Application Notes for anti-CD38 antibody    Research Application(s): Induction of B lymphocyte proliferation
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NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.
 NCBI GI #    1911103
 NCBI GeneID    952
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 UniProt Primary Accession #    P28907 [Other Products]
 UniProt Secondary Accession #    O00121; O00122; Q96HY4 [Other Products]
 UniProt Related Accession #    P28907; Q4FCX6 [Other Products]
 Molecular Weight    34,328 Da [Similar Products]
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 NCBI Official Full Name    CD38
 NCBI Official Synonym Full Names    CD38 molecule
 NCBI Official Symbol    CD38 [Similar Products]
 NCBI Official Synonym Symbols   
T10
[Similar Products]
 NCBI Protein Information    ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); OTTHUMP00000158633; OTTHUMP00000217743; NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
 UniProt Protein Name    ADP-ribosyl cyclase 1
 UniProt Synonym Protein Names   
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
 Protein Family    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
 UniProt Gene Name    CD38 [Similar Products]
 UniProt Entry Name    CD38_HUMAN
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 NCBI Summary for CD38    CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq]
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 UniProt Comments for CD38    Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Catalytic activity: NAD+ + H2O = ADP-ribose + nicotinamide.

Enzyme regulation: ATP inhibits the hydrolyzing activity.

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Ref.2

Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Sequence similarities: Belongs to the ADP-ribosyl cyclase family.
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Product References and Citations for anti-CD38 antibody

   1. Harada, N., L. Santos-Argumedo, R. Chang, J. C. Grimaldi, F. E. Lund, C. I. Brannan, N. G. Copeland, N. A. Jenkins, A. W. Heath, and R. M. Parkhouse. 1993. J. Immunol. 151:3111.
2. Santos-Argumedo, L., C. Teixeira, G. Preece, P. A. Kirkham, and R. M. E. Parkhouse. 1993. J. Immunol. 151:3119.
3. Howard, M., J. C. Grimaldi, J. F. Bazan, F. E. Lund, L. Santos-Argumedo, R. M. E. Parkhouse, T. F. Walseth, and H. C. Lee. 1993. Science 262:1056.
4. Lund, F., N. Solvason, J. C. Grimaldi, R. M. Parkhouse, and M. Howard. 1995. Immunol. Today 16:469.
5. Kirkham, P. A., L. Santos-Argumedo, M. M. Harnett, and R. M. Parkhouse. 1994. Immunology 83:513.
6. Bean, A. G. D., D. I. Godfrey, W. G. Ferlin, L. Santos-Argumedo, R. M. E. Parkhouse, M. C. Howard, and A. Zlotnik. 1996. Int. Immunol. 7:213.
7. Oliver, A. and J. Kearney. 1996. Personal Communication.
8. Kumagai, M., E. Coustan-Smith, D. J. Murray, O. Silvennoinen, K. G. Murti, W. E. Evans, F. Malavasi, and D. Campana. 1995. J. Exp. Med. 181:1101.
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 Research Articles on CD38    1. gene mutational status and CD38 expression correlated with good Methylation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD38 antibodyPathways associated with anti-CD38 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >840 publications with CD38 and CD4
 PECAM1 antibody  >55 publications with CD38 and PECAM1
 CD9 antibody  >49 publications with CD38 and CD9
 LCK antibody  >8 publications with CD38 and LCK
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
Diseases associated with anti-CD38 antibodyOrgans/Tissues associated with anti-CD38 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1515 publications with CD38 and Neoplasms
 Lymphoma Antibodies  >405 publications with CD38 and Lymphoma
 Vascular Diseases Antibodies  >333 publications with CD38 and Vascular Diseases
 Lymphoma, B-Cell Antibodies  >244 publications with CD38 and Lymphoma, B-Cell
 Leukemia, Myeloid, Acute Antibodies  >241 publications with CD38 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >142 publications with CD38 and Inflammation
 Lymphoma, T-Cell Antibodies  >93 publications with CD38 and Lymphoma, T-Cell
 Anemia Antibodies  >80 publications with CD38 and Anemia
 Bone Marrow Neoplasms Antibodies  >64 publications with CD38 and Bone Marrow Neoplasms
 Cell Transformation, Neoplastic Antibodies  >62 publications with CD38 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3004 publications with CD38 and Blood
 Bone Marrow Antibodies  >1151 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >222 publications with CD38 and Lymph Node
 Liver Antibodies  >171 publications with CD38 and Liver
 Lymph Antibodies  >156 publications with CD38 and Lymph
 Spleen Antibodies  >133 publications with CD38 and Spleen
 Tonsil Antibodies  >102 publications with CD38 and Tonsil
 Pharynx Antibodies  >98 publications with CD38 and Pharynx
 Muscle Antibodies  >97 publications with CD38 and Muscle
 Thymus Antibodies  >94 publications with CD38 and Thymus
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