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anti-CD39 antibody :: Rat anti-Human CD39 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570338 anti-CD39 antibody
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD39, Monoclonal Antibody

 Also Known As   

Rat anti CD39, Ectonucleoside triphosphate diphosphohydrolase 1

 Product Gene Name   

anti-CD39 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615683
 3D Structure    ModBase 3D Structure for P49961
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    R22
 Host    Rat
 Species Reactivity    Human
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 Specificity    The antibody R22 is directed against human CD39. The antibody has not been tested for cross reactivity with other species.
 Form/Format    Each vial contains 100ul 1mg/ml purified monoclonal antibody in phosphate buffered saline (PBS) containing 0.09% sodium azide.
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 Product Type    Primary Antibodies
 Source Note    R22 is a rat monoclonal IgG1 antibody derived by fusion of SP2/0 mouse myeloma cells with splenocytes from a WAG/Rij rat immunized with JY cells, a human B lymphoblastoid cell line.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-CD39 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD39 antibody

   CD39 is a transmembrane cell surface protein, which is a member of the ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) family. The CD39 molecule is primarily involved in the metabolism of purine nucleotides, converting extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP). In conjunction with CD73 (5' nucleotidase), CD39 plays a key role in regulating immunity and inflammation through the production of adenosine and purinergic signalling pathways. In addition, CD39 is reported to mediate B cell homotypic adhesion and inhibit ADP-induced platelet aggregation.

CD39 was originally identified on Epstein Barr virus transformed B cell lines and described as a B-cell activation marker. However, subsequent studies have shown that CD39 is also expressed on activated T-cells, T-regulatory cells, natural killer cells, tissue macrophages and endothelial cells. Increased expression of CD39 has also been reported in cases of chronic lymphocytic leukaemia and several solid tumours including colorectal and pancreatic cancer suggesting a potential role for CD39 in tumour development and progression.
 Product Categories/Family for anti-CD39 antibody    CD Marker, Cancer, Immunology
 Applications Tested/Suitable for anti-CD39 antibody   

Flow Cytometry (FC)

 Application Notes for anti-CD39 antibody    The R22 antibody is suitable for the detection of human CD39 antigen by flow cytometry. Human spleen is suitable as a positive control.

Optimal antibody dilutions for the different applications should be determined by titration.
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NCBI/Uniprot data below describe general gene information for CD39. It may not necessarily be applicable to this product.
 NCBI GI #    147905700
 NCBI GeneID    953
 NCBI Accession #    NP_001091645.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098175.1 [Other Products]
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 UniProt Primary Accession #    P49961 [Other Products]
 UniProt Secondary Accession #    Q5T561; Q5T562; Q86VV3; Q9UQQ9; Q9Y3Q9; A9Z1X8; B4DWB9; B4E1X1; B7Z599; G3XAF6 [Other Products]
 UniProt Related Accession #    P49961 [Other Products]
 Molecular Weight    59,325 Da
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 NCBI Official Full Name    ectonucleoside triphosphate diphosphohydrolase 1 isoform 2
 NCBI Official Synonym Full Names    ectonucleoside triphosphate diphosphohydrolase 1
 NCBI Official Symbol    ENTPD1 [Similar Products]
 NCBI Official Synonym Symbols   
CD39; SPG64; ATPDase; NTPDase-1
[Similar Products]
 NCBI Protein Information    ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; CD39 antigen; ecto-apyrase; ecto-ATPase 1; ecto-ATPDase 1; ecto-ATP diphosphohydrolase 1; lymphoid cell activation antigen
 UniProt Protein Name    Ectonucleoside triphosphate diphosphohydrolase 1
 UniProt Synonym Protein Names   
Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD_antigen: CD39
 UniProt Gene Name    ENTPD1 [Similar Products]
 UniProt Synonym Gene Names    CD39; NTPDase 1; Ecto-ATPDase 1; Ecto-ATPase 1 [Similar Products]
 UniProt Entry Name    ENTP1_HUMAN
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 NCBI Summary for CD39    The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
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 UniProt Comments for CD39    ENTPD1: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Hydrolase; Extracellular matrix; EC 3.6.1.5; Nucleotide Metabolism - pyrimidine; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; basal lamina

Molecular Function: protein binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; ATP binding

Biological Process: G-protein coupled receptor protein signaling pathway; platelet activation; purine ribonucleoside diphosphate catabolic process; blood coagulation; cell adhesion

Disease: Spastic Paraplegia 64, Autosomal Recessive
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Product References and Citations for anti-CD39 antibody

   1. Kansas GS, Wood GS, Tedder TF. (1991). Expression, distribution and biochemistry of CD39. J Immunol. 146:2235-2244.
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 Research Articles on CD39    1. ecto-nucleotidases CD39 and CD73 are expressed in human endometrial tumors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rat anti CD39, Ectonucleoside triphosphate diphosphohydrolase 1
 Catalog #  Product Name  Catalog #  Product Name
 MBS219372  RAT ANTI MOUSE CD39:FITC  MBS666075  anti-human CD39-Biotin
 MBS2546017  Recombinant Human ENTPD3 / NTPDase3 / CD39L3 Protein (His tag)  MBS666163  anti-human CD39-R-PE
 MBS610804  CD39L3 (CD39-like 3, Ectonucleoside Triphosphate Diphosphohydrolase-3, eNTPDase 3, HB6) (Biotin)  MBS625204  CD39L1 (Ectonucleoside Triphosphate Diphosphohydrolase 2, NTPDase 2, CD39 Antigen-like 1, Ecto-ATP D...
 MBS2547002  Recombinant Mouse CD39 / ENTPD1 Protein (His tag)  MBS214897  MOUSE ANTI HUMAN CD39:RPE
 MBS668165  CD39 Monoclonal Antibody  MBS666194  anti-human CD39-FITC
Products associated with anti-CD39 antibodyPathways associated with anti-CD39 antibody
 Reference Product  PubMed Publications
 NT5E antibody  >2 publications with CD39 and NT5E
 ENTPD6 antibody  >1 publications with CD39 and ENTPD6
 ENTPD5 antibody  >1 publications with CD39 and ENTPD5
 Products by Pathway  Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 UTP And CTP Dephosphorylation II Pathway antibodies  UTP And CTP Dephosphorylation II Pathway Diagram
 UTP And CTP Dephosphorylation II Pathway antibodies  UTP And CTP Dephosphorylation II Pathway Diagram
Diseases associated with anti-CD39 antibodyOrgans/Tissues associated with anti-CD39 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >13 publications with CD39 and Inflammation
 Disease Models, Animal Antibodies  >8 publications with CD39 and Disease Models, Animal
 Necrosis Antibodies  >5 publications with CD39 and Necrosis
 Kidney Diseases Antibodies  >3 publications with CD39 and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with CD39 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with CD39 and Nervous System Diseases
 Atherosclerosis Antibodies  >1 publications with CD39 and Atherosclerosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with CD39 and Carcinoma, Hepatocellular
 Hypertension Antibodies  >1 publications with CD39 and Hypertension
 Adenocarcinoma Antibodies  >1 publications with CD39 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with CD39 and Blood
 Muscle Antibodies  >9 publications with CD39 and Muscle
 Liver Antibodies  >8 publications with CD39 and Liver
 Kidney Antibodies  >4 publications with CD39 and Kidney
 Heart Antibodies  >3 publications with CD39 and Heart
 Pancreas Antibodies  >3 publications with CD39 and Pancreas
 Bone Marrow Antibodies  >3 publications with CD39 and Bone Marrow
 Bone Antibodies  >3 publications with CD39 and Bone
 Embryonic Tissue Antibodies  >2 publications with CD39 and Embryonic Tissue
 Skin Antibodies  >2 publications with CD39 and Skin
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