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anti-CD4 antibody :: Rat CD4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213552
Testing Data
Unit / Price
100 Tests  /  $420 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD4:RPE

 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P06332
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    YTS177.9
 Host    Rat
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
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 Reconstitution    Reconstitute with 1 ml distilled water
Perservative Stabilisers
 Immunogen    Mouse spleen cells
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD4 antibody

   Rat anti Mouse CD4 antibody, clone YTS177.9 reacts with the Mouse CD4 antigen, non polymorphic epitope (Qin et al. 1990). Rat anti Mouse CD4 antibody, Rat anti Mouse CD4 antibody, clone YTS177.9 reacts with CD4 transfectants (Cobbold et al. 1990).Rat anti Mouse CD4 antibody, clone YTS177.9 also blocks MHC-II dependant T-cell responses in vitro and in vivo and induces tolerance (Qin et al. 1990) and Cobbold et al. 1990).
 Applications Tested/Suitable for anti-CD4 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD4 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul of whole blood.The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD4 antibody    Staining of mouse peripheral blood lymphocytes with Rat anti Mouse CD4:FITC (MBS210616)
anti-CD4 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    7304953
 NCBI GeneID    12504
 NCBI Accession #    NP_038516.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013488.2 [Other Products]
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 UniProt Primary Accession #    P06332 [Other Products]
 UniProt Related Accession #    P06332 [Other Products]
 Molecular Weight    24,473 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD4
 NCBI Official Synonym Full Names    CD4 antigen
 NCBI Official Symbol    Cd4 [Similar Products]
 NCBI Official Synonym Symbols   
L3T4; Ly-4
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
 UniProt Protein Name    T-cell surface glycoprotein CD4
 UniProt Synonym Protein Names   
T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; CD_antigen: CD4
 Protein Family    CD40 ligand
 UniProt Gene Name    Cd4 [Similar Products]
 UniProt Entry Name    CD4_MOUSE
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: endoplasmic reticulum membrane; cell surface; membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; zinc ion binding; coreceptor activity; glycoprotein binding; protein kinase binding

Biological Process: maintenance of cellular protein localization; T cell activation; immune system process; cytokine production; T cell selection; positive regulation of calcium-mediated signaling; induction by virus of cell-cell fusion in host; defense response to Gram-negative bacterium; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; protein palmitoleylation; immune response; positive regulation of T cell activation; cell adhesion; regulation of T cell activation; T cell differentiation
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 Research Articles on CD4    1. This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to RAT ANTI MOUSE CD4:RPE
 Catalog #  Product Name  Catalog #  Product Name
 MBS2533935  Anti-Human CD40 Antibody (PE conjugated)  MBS215048  MOUSE ANTI HUMAN CD49f
 MBS214760  RAT ANTI DOG CD45R:RPE  MBS2018068  FITC-linked Antibody to Cluster Of Differentiation 40 Ligand (CD40L)
 MBS2038118  HRP-Linked Polyclonal Antibody to Cluster Of Differentiation 40 Ligand (CD40L)  MBS729187  Mouse sCD4 ELISA Kit
 MBS1063527  Recombinant Macaca fuscata fuscata T-cell surface glycoprotein CD4 (CD4)  MBS7603176  PTPRCAP / CD45AP Rabbit Polyclonal
 MBS853701  CD40 Antibody  MBS666668  anti-human CD43-Purified Preservative Free
Pathways associated with anti-CD4 antibodyDiseases associated with anti-CD4 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12216 publications with CD4 and Inflammation
 Disease Models, Animal Antibodies  >9067 publications with CD4 and Disease Models, Animal
 Necrosis Antibodies  >7648 publications with CD4 and Necrosis
 Lung Diseases Antibodies  >6767 publications with CD4 and Lung Diseases
 Liver Diseases Antibodies  >4683 publications with CD4 and Liver Diseases
 AIDS-Related Opportunistic Infections Antibodies  >4364 publications with CD4 and AIDS-Related Opportunistic Infections
 Carcinoma Antibodies  >3428 publications with CD4 and Carcinoma
 Cardiovascular Diseases Antibodies  >3187 publications with CD4 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >2980 publications with CD4 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >2495 publications with CD4 and Vascular Diseases
Organs/Tissues associated with anti-CD4 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >9464 publications with CD4 and Spleen
 Thymus Antibodies  >7207 publications with CD4 and Thymus
 Mixed Antibodies  >3838 publications with CD4 and Mixed
 Brain Antibodies  >3321 publications with CD4 and Brain
 Salivary Gland Antibodies  >424 publications with CD4 and Salivary Gland
 Mammary Gland Antibodies  >137 publications with CD4 and Mammary Gland
 Pineal Gland Antibodies  >33 publications with CD4 and Pineal Gland
 Uncharacterized Tissue Antibodies  >20 publications with CD4 and Uncharacterized Tissue
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