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anti-CD4 antibody :: Rat anti-Murine CD4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532109 anti-CD4 antibody
Unit / Price
0.5 mg  /  $420 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Monoclonal Antibody

 Also Known As   

CD4 antibody (biotin)

 Product Synonym Names    Monoclonal CD4; Anti-CD4; W3/25; included; CD4; L3T4; T cell surface antigen T4/Leu3; T cell differentiation antigen L3T4; MGC165891; Lymphocyte antigen CD4; Leu3; CD 4; T cell surface antigen T4/Leu 3; T Cell Antigen T4; CD4 antigen (p55); CD-4; T cell OKT4 deficiency; CD4mut; T Cell Surface Glycoprotein CD4; T-cell surface antigen T4/Leu-3; p55; Ly-4; W3/25 antigen; CD4+ Lymphocyte deficiency; T cell antigen T4/LEU3; CD4_HUMAN; T-cell surface glycoprotein CD4
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P06332
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    GK1.5
 Host    Rat
 Species Reactivity    Murine
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.5 mg/ml (lot specific)
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 Biological Significance    CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    Biotin
 Immunogen    CD4 antibody (biotin) was raised in rat using cloned murine CTL line V4 as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD4 antibody

   Rat monoclonal CD4 antibody (biotin)
 Product Categories/Family for anti-CD4 antibody    Immunology; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD4 antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    24659577
 NCBI GeneID    12504
 NCBI Accession #    AAH39137.1 [Other Products]
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 UniProt Primary Accession #    P06332 [Other Products]
 UniProt Related Accession #    P06332 [Other Products]
 Molecular Weight    24,473 Da
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 NCBI Official Full Name    CD4 antigen
 NCBI Official Synonym Full Names    CD4 antigen
 NCBI Official Symbol    Cd4 [Similar Products]
 NCBI Official Synonym Symbols   
L3T4; Ly-4
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4
 UniProt Protein Name    T-cell surface glycoprotein CD4
 UniProt Synonym Protein Names   
T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; CD_antigen: CD4
 Protein Family    CD40 ligand
 UniProt Gene Name    Cd4 [Similar Products]
 UniProt Entry Name    CD4_MOUSE
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: endoplasmic reticulum membrane; cell surface; membrane; endoplasmic reticulum lumen; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; enzyme binding; zinc ion binding; coreceptor activity; glycoprotein binding; protein kinase binding

Biological Process: maintenance of cellular protein localization; T cell activation; immune system process; cytokine production; T cell selection; positive regulation of calcium-mediated signaling; defense response to Gram-negative bacterium; induction by virus of cell-cell fusion in host; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; protein palmitoleylation; immune response; positive regulation of T cell activation; cell adhesion; T cell differentiation; regulation of T cell activation
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 Research Articles on CD4    1. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD4 antibodyPathways associated with anti-CD4 antibody
 Reference Product  PubMed Publications
 Lck antibody  >808 publications with CD4 and Lck
 Zap70 antibody  >278 publications with CD4 and Zap70
 Lat antibody  >139 publications with CD4 and Lat
 Ptprc antibody  >96 publications with CD4 and Ptprc
 Cd8a antibody  >86 publications with CD4 and Cd8a
 Cd3e antibody  >71 publications with CD4 and Cd3e
 Cd247 antibody  >8 publications with CD4 and Cd247
 Cd3d antibody  >6 publications with CD4 and Cd3d
 Cd3g antibody  >6 publications with CD4 and Cd3g
 H2-Ab1 antibody  >4 publications with CD4 and H2-Ab1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
Diseases associated with anti-CD4 antibodyOrgans/Tissues associated with anti-CD4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12696 publications with CD4 and Inflammation
 Necrosis Antibodies  >7811 publications with CD4 and Necrosis
 Lung Diseases Antibodies  >6931 publications with CD4 and Lung Diseases
 Liver Diseases Antibodies  >4818 publications with CD4 and Liver Diseases
 AIDS-Related Opportunistic Infections Antibodies  >4401 publications with CD4 and AIDS-Related Opportunistic Infections
 Carcinoma Antibodies  >3518 publications with CD4 and Carcinoma
 Cardiovascular Diseases Antibodies  >3287 publications with CD4 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >3040 publications with CD4 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >2567 publications with CD4 and Vascular Diseases
 Pneumonia Antibodies  >2526 publications with CD4 and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >9629 publications with CD4 and Spleen
 Thymus Antibodies  >7276 publications with CD4 and Thymus
 Mixed Antibodies  >3910 publications with CD4 and Mixed
 Brain Antibodies  >3415 publications with CD4 and Brain
 Salivary Gland Antibodies  >429 publications with CD4 and Salivary Gland
 Mammary Gland Antibodies  >137 publications with CD4 and Mammary Gland
 Pineal Gland Antibodies  >33 publications with CD4 and Pineal Gland
 Uncharacterized Tissue Antibodies  >22 publications with CD4 and Uncharacterized Tissue
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