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anti-CD4 antibody :: Mouse anti-Human CD4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532397 anti-CD4 antibody
Unit / Price
100 Tests  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Monoclonal Antibody

 Also Known As   

CD4 antibody (Allophycocyanin)

 Product Synonym Names    Monoclonal CD4; Anti-CD4; T cell antigen T4/LEU3; T Cell Surface Glycoprotein CD4; CD4 antigen (p55); T cell OKT4 deficiency; T Cell Antigen T4; CD 4; CD-4; W3/25; Leu3; CD4+ Lymphocyte deficiency; p55; T cell surface antigen T4/Leu3; Ly-4; W3/25 antigen; L3T4; CD4mut; T cell surface antigen T4/Leu 3; T-cell surface glycoprotein CD4; included; CD4_HUMAN; T cell differentiation antigen L3T4; Lymphocyte antigen CD4; CD4; MGC165891; T-cell surface antigen T4/Leu-3
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q13969
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    RFT-4G
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.1 mg/ml (lot specific)
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 Biological Significance    CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    Allophycocyanin
 Immunogen    CD4 antibody (Allophycocyanin) was raised in mouse using human CD4 as the immunoge.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD4 antibody

   Mouse monoclonal CD4 antibody (Allophycocyanin)
 Product Categories/Family for anti-CD4 antibody    Immunology; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD4 antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    3947700
 NCBI GeneID    920
 NCBI Accession #    CAA60883.1 [Other Products]
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 UniProt Primary Accession #    Q13969 [Other Products]
 UniProt Related Accession #    P01730 [Other Products]
 Molecular Weight    7,844 Da
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 NCBI Official Full Name    CD4, partial
 NCBI Official Synonym Full Names    CD4 molecule
 NCBI Official Symbol    CD4 [Similar Products]
 NCBI Official Synonym Symbols   
CD4mut
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4
 UniProt Protein Name    CD4 protein
 UniProt Synonym Protein Names   
CD4 protein
 Protein Family    CD40 ligand
 UniProt Gene Name    CD4 [Similar Products]
 UniProt Entry Name    Q13969_HUMAN
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 NCBI Summary for CD4    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: T cell receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum lumen; early endosome; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; enzyme binding; protein homodimerization activity; zinc ion binding; extracellular matrix structural constituent; coreceptor activity; receptor activity; glycoprotein binding; protein kinase binding; MHC class II protein binding

Biological Process: maintenance of cellular protein localization; viral reproduction; positive regulation of interleukin-2 biosynthetic process; T cell selection; cytokine production; positive regulation of calcium-mediated signaling; defense response to Gram-negative bacterium; signal transduction; induction by virus of cell-cell fusion in host; T cell receptor signaling pathway; enzyme linked receptor protein signaling pathway; regulation of defense response to virus by virus; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; protein palmitoleylation; T cell costimulation; innate immune response; entry into host cell; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of T cell activation; T cell differentiation

Disease: Okt4 Epitope Deficiency
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 Research Articles on CD4    1. The study shows that activated CD4+ T cells can produce 1,25(OH)2D3, and that 1,25(OH)2D3 induces a 2-fold up-regulation of the VDR protein expression in activated CD4+ T cells by protecting the VDR against proteasomal degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD4 antibodyOrgans/Tissues associated with anti-CD4 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98848 publications with CD4 and Blood
 Spleen Antibodies  >9629 publications with CD4 and Spleen
 Lymph Node Antibodies  >8661 publications with CD4 and Lymph Node
 Thymus Antibodies  >7276 publications with CD4 and Thymus
 Bone Antibodies  >7084 publications with CD4 and Bone
 Lung Antibodies  >6766 publications with CD4 and Lung
 Bone Marrow Antibodies  >6246 publications with CD4 and Bone Marrow
 Liver Antibodies  >6000 publications with CD4 and Liver
 Intestine Antibodies  >3434 publications with CD4 and Intestine
 Brain Antibodies  >3415 publications with CD4 and Brain
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