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anti-CD4 antibody :: Mouse anti-Chicken CD4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673891 anti-CD4 antibody
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Monoclonal Antibody

 Also Known As   

Mouse Anti-Chicken CD4-PE

 Product Synonym Names    Mouse Anti-Chicken CD4 - Phycoerythrin-Labeled; Mouse Anti-Chicken CD4
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6898638..6929976). Location: 12pter-p12
 3D Structure    ModBase 3D Structure for Q13969
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 Clonality    Monoclonal
 Isotype    Mouse IgM kappa
 Clone Number    EP96
 Host    Mouse
 Species Reactivity    Chicken
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 Specificity    Chicken CD4 (Mr 64 kDa).
CD4 is a type I transmembrane glycoprotein expressed on approximately 70% of thymocytes, 10% of spleen cells and 45% of peripheral blood lymphocytes, but <1% of bursal cells.1,2 MAb EP96 inhibits both PHA- and Con A-induced proliferative responses of splenocytes, and PWM-induced IL-2 production.1
 Form/Format    R - phycoerythrin (R - PE) Conjugate
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 Characterization    To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested to conform to characteristics of a standard reference reagent using immunofluorescence staining and analysis on a Becton Dickinson FACScan flow cytometer
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD4 antibody   

Flow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation

 Application Notes for anti-CD4 antibody    Research Application(s): Identification and localization of CD4+ T cells in acetone-fixed, frozen tissue sections 3
Inhibition of mitogen-induced proliferation

Flow Cytometry Suggested Dilution: <= 0.2 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    3947700
 NCBI GeneID    920
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 UniProt Primary Accession #    Q13969 [Other Products]
 UniProt Related Accession #    P01730; Q13969; Q6LCP8 [Other Products]
 Molecular Weight    7,844 Da [Similar Products]
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 NCBI Official Full Name    CD4
 NCBI Official Synonym Full Names    CD4 molecule
 NCBI Official Symbol    CD4 [Similar Products]
 NCBI Official Synonym Symbols   
CD4mut
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); OTTHUMP00000238897; T-cell surface antigen T4/Leu-3
 UniProt Protein Name    CD4 protein
 Protein Family    CD40 ligand
 UniProt Gene Name    CD4 [Similar Products]
 UniProt Synonym Gene Names    CD4 receptor [Similar Products]
 UniProt Entry Name    Q13969_HUMAN
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 NCBI Summary for CD4    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq]
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: T cell receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum lumen; early endosome; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; protein homodimerization activity; enzyme binding; zinc ion binding; extracellular matrix structural constituent; coreceptor activity; receptor activity; glycoprotein binding; protein kinase binding; MHC class II protein binding

Biological Process: maintenance of cellular protein localization; viral reproduction; positive regulation of interleukin-2 biosynthetic process; T cell selection; cytokine production; positive regulation of calcium-mediated signaling; signal transduction; induction by virus of cell-cell fusion in host; defense response to Gram-negative bacterium; enzyme linked receptor protein signaling pathway; T cell receptor signaling pathway; regulation of defense response to virus by virus; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; protein palmitoleylation; T cell costimulation; innate immune response; entry into host cell; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; T cell differentiation; regulation of T cell activation

Disease: Okt4 Epitope Deficiency
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Product References and Citations for anti-CD4 antibody

   1. Ratcliffe, M. 1996. Personal communication.
2. Cooper, M.D., R.P. Bucy, and C.-L. Chen. 1990. In: The Avian Model in Developmental Biology: From Organism to Genes. Editions du CNRS, pp. 239-249.
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 Research Articles on CD4    1. anti-TIM3 requires IFN-gamma producing CD8(+) T cells and CD4(+) T cells, and a higher ratio of tumor infiltrating CD8(+):CD4(+) T cells correlating with therapeutic success
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD4 antibodyPathways associated with anti-CD4 antibody
 Reference Product  PubMed Publications
 CD28 antibody  >3636 publications with CD4 and CD28
 CCR5 antibody  >2750 publications with CD4 and CCR5
 PTPRC antibody  >2705 publications with CD4 and PTPRC
 CD2 antibody  >2244 publications with CD4 and CD2
 env antibody  >2229 publications with CD4 and env
 IL2RA antibody  >2167 publications with CD4 and IL2RA
 CXCR4 antibody  >1893 publications with CD4 and CXCR4
 CD5 antibody  >1510 publications with CD4 and CD5
 CD44 antibody  >1169 publications with CD4 and CD44
 CD38 antibody  >927 publications with CD4 and CD38
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
Diseases associated with anti-CD4 antibodyOrgans/Tissues associated with anti-CD4 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13808 publications with CD4 and Neoplasms
 Inflammation Antibodies  >9479 publications with CD4 and Inflammation
 Disease Models, Animal Antibodies  >7382 publications with CD4 and Disease Models, Animal
 Necrosis Antibodies  >6689 publications with CD4 and Necrosis
 Nervous System Diseases Antibodies  >6265 publications with CD4 and Nervous System Diseases
 Lung Diseases Antibodies  >5777 publications with CD4 and Lung Diseases
 Lymphoma Antibodies  >4322 publications with CD4 and Lymphoma
 AIDS-Related Opportunistic Infections Antibodies  >4004 publications with CD4 and AIDS-Related Opportunistic Infections
 Liver Diseases Antibodies  >3805 publications with CD4 and Liver Diseases
 Brain Diseases Antibodies  >3150 publications with CD4 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >79630 publications with CD4 and Blood
 Spleen Antibodies  >7905 publications with CD4 and Spleen
 Lymph Node Antibodies  >6983 publications with CD4 and Lymph Node
 Thymus Antibodies  >6440 publications with CD4 and Thymus
 Bone Antibodies  >5493 publications with CD4 and Bone
 Lung Antibodies  >4975 publications with CD4 and Lung
 Bone Marrow Antibodies  >4931 publications with CD4 and Bone Marrow
 Liver Antibodies  >4481 publications with CD4 and Liver
 Intestine Antibodies  >2596 publications with CD4 and Intestine
 Kidney Antibodies  >2505 publications with CD4 and Kidney
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