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anti-CD4 antibody :: Mouse anti-Human CD4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9200524
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD4, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal Antibody (Mab)

 Product Synonym Names    T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD4; CD4
 Product Gene Name   

anti-CD4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186940
 3D Structure    ModBase 3D Structure for P01730
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    OKT4
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This CD4 monoclonal antibody is generated from mouse immunized with CD4 recombinant protein.
 Form/Format    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
 Concentration    Vial Concentration: 0.47mg/ml (lot specific)
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 Antigen Source    HUMAN
 Function    Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
 Cellular Location    Cell membrane; Single-pass type I membrane protein Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD4 antibody

   This gene encodes a membrane glycoprotein of T lymphocytes
that interacts with major histocompatibility complex class II
antigenes and is also a receptor for the human immunodeficiency
virus. This gene is expressed not only in T lymphocytes, but also
in B cells, macrophages, and granulocytes. It is also expressed in
specific regions of the brain. The protein functions to initiate or
augment the early phase of T-cell activation, and may function as
an important mediator of indirect neuronal damage in infectious and
immune-mediated diseases of the central nervous system. Multiple
alternatively spliced transcript variants encoding different
isoforms have been identified in this gene.
 Product Categories/Family for anti-CD4 antibody    Immunology; Signal Transduction
 Applications Tested/Suitable for anti-CD4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CD4 antibody    WB~~1:100~250
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 Western Blot (WB) of anti-CD4 antibody    CD4 Antibody western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CD4 antibody detected the CD4 protein (arrow).
anti-CD4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD4. It may not necessarily be applicable to this product.
 NCBI GI #    10835167
 NCBI GeneID    920
 NCBI Accession #    NP_000607.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000616.4 [Other Products]
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 UniProt Primary Accession #    P01730 [Other Products]
 UniProt Secondary Accession #    Q4ZGK2; Q5U066; Q9UDE5; B2R737; D3DUS5 [Other Products]
 UniProt Related Accession #    P01730 [Other Products]
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 NCBI Official Full Name    T-cell surface glycoprotein CD4 isoform 1
 NCBI Official Synonym Full Names    CD4 molecule
 NCBI Official Symbol    CD4 [Similar Products]
 NCBI Official Synonym Symbols   
CD4mut
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD4
 UniProt Protein Name    T-cell surface glycoprotein CD4
 UniProt Synonym Protein Names   
T-cell surface antigen T4/Leu-3; CD_antigen: CD4
 Protein Family    CD40 ligand
 UniProt Gene Name    CD4 [Similar Products]
 UniProt Entry Name    CD4_HUMAN
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 NCBI Summary for CD4    This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for CD4    CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: T cell receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum lumen; early endosome; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; enzyme binding; transmembrane receptor activity; protein homodimerization activity; zinc ion binding; extracellular matrix structural constituent; coreceptor activity; receptor activity; glycoprotein binding; protein kinase binding; MHC class II protein binding

Biological Process: maintenance of cellular protein localization; viral reproduction; positive regulation of interleukin-2 biosynthetic process; T cell selection; cytokine production; positive regulation of calcium-mediated signaling; defense response to Gram-negative bacterium; induction by virus of cell-cell fusion in host; signal transduction; T cell receptor signaling pathway; enzyme linked receptor protein signaling pathway; regulation of defense response to virus by virus; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of protein kinase activity; T cell costimulation; protein palmitoleylation; innate immune response; immune response; entry into host cell; transmembrane receptor protein tyrosine kinase signaling pathway; T cell differentiation; regulation of T cell activation

Disease: Okt4 Epitope Deficiency
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Product References and Citations for anti-CD4 antibody

   Pourgheysari, B., et al. Blood 116(16):2968-2974(2010)
Rudd, C.E., et al. J. Immunol. 185(5):2645-2649(2010)
Ammirati, E., et al. Arterioscler. Thromb. Vasc. Biol. 30(9):1832-1841(2010)
Schenkel, J.M., et al. J. Immunol. 185(4):2013-2019(2010)
Lee, K.M., et al. Am. J. Hematol. 85(8):560-563(2010)
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 Research Articles on CD4    1. The study shows that activated CD4+ T cells can produce 1,25(OH)2D3, and that 1,25(OH)2D3 induces a 2-fold up-regulation of the VDR protein expression in activated CD4+ T cells by protecting the VDR against proteasomal degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD4 antibodyDiseases associated with anti-CD4 antibody
 Products by Pathway  Pathway Diagram
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 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12654 publications with CD4 and Inflammation
 Necrosis Antibodies  >7797 publications with CD4 and Necrosis
 Lung Diseases Antibodies  >6912 publications with CD4 and Lung Diseases
 Liver Diseases Antibodies  >4805 publications with CD4 and Liver Diseases
 AIDS-Related Opportunistic Infections Antibodies  >4399 publications with CD4 and AIDS-Related Opportunistic Infections
 Carcinoma Antibodies  >3509 publications with CD4 and Carcinoma
 Cardiovascular Diseases Antibodies  >3283 publications with CD4 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >3035 publications with CD4 and Neoplasms, Experimental
 Vascular Diseases Antibodies  >2566 publications with CD4 and Vascular Diseases
 Pneumonia Antibodies  >2520 publications with CD4 and Pneumonia
Organs/Tissues associated with anti-CD4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98693 publications with CD4 and Blood
 Spleen Antibodies  >9621 publications with CD4 and Spleen
 Lymph Node Antibodies  >8651 publications with CD4 and Lymph Node
 Thymus Antibodies  >7269 publications with CD4 and Thymus
 Bone Antibodies  >7065 publications with CD4 and Bone
 Lung Antibodies  >6747 publications with CD4 and Lung
 Bone Marrow Antibodies  >6230 publications with CD4 and Bone Marrow
 Liver Antibodies  >5979 publications with CD4 and Liver
 Intestine Antibodies  >3425 publications with CD4 and Intestine
 Brain Antibodies  >3411 publications with CD4 and Brain
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