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anti-CD40 antibody :: Rat anti-Mouse CD40 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS520120
Testing Data
Unit / Price
0.1 mg  /  $200 +1 FREE 8GB USB
0.3 mg  /  $370 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40, Monoclonal Antibody

 Also Known As   

Anti-Mouse CD40, Biotin (Clone 3/23) (rat IgG2a)

 Product Synonym Names    CD40, Biotin (Clone 3/23) (rat IgG2a); Biotin Anti-Mouse CD40 Monoclonal Antibody
 Product Gene Name   

anti-CD40 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (44746899..44758384). Location: 20q12-q13.2
 OMIM    109535
 3D Structure    ModBase 3D Structure for P25942
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 Clonality    Monoclonal
 Isotype    Rat IgG2a
 Clone Number    2/23
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    CD40 (gp39 receptor) (Mouse CD40)
 Form/Format    Biotin
 Concentration    Antibody Concentration: 0.1 mg/ml (lot specific)
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 Presentation    100 ug or 300 ug Biotin conjugated Ig buffered in PBS, 0.1% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
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 Preparation and Storage    Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles. Check label for expiry date.
 Other Notes    Small volumes of anti-CD40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD40 antibody

   anti-mouse monoclonal antibody reacts with CD40 which is expressed on B-lymphocytes and on a subset of both CD4+ and CD8+ T cells in the adult (but not neonatal) spleen1. The level of CD40 on B cells is enhanced following activation buy LPS1. The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal center formation, and generating B cell memory2. Stimulating cells with immobilized 3/23 mAb increases expression of CD86 (B7.2) on B cells1,3. Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3. Costimulation with 3/23 mAb and IL-4 rescues B cells from apoptosis induced by hypercross-linking of sIgM or sIgD3. This antibody is suitable for use in flow cytometry. Other applications of this antibody include IHC of acetonefixed frozen sections2.
 Applications Tested/Suitable for anti-CD40 antibody   

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

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 Testing Data of anti-CD40 antibody    anti-CD40 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD40. It may not necessarily be applicable to this product.
 NCBI GI #    23312371
 NCBI GeneID    958
 NCBI Accession #    NP_690593.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_152854.2 [Other Products]
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 UniProt Primary Accession #    P25942 [Other Products]
 UniProt Secondary Accession #    Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0; E1P5S9 [Other Products]
 UniProt Related Accession #    P25942 [Other Products]
 Molecular Weight    30,619 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 5 isoform 2
 NCBI Official Synonym Full Names    CD40 molecule, TNF receptor superfamily member 5
 NCBI Official Symbol    CD40 [Similar Products]
 NCBI Official Synonym Symbols   
p50; Bp50; CDW40; TNFRSF5
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 5
 UniProt Synonym Protein Names   
B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40 [Similar Products]
 UniProt Synonym Gene Names    TNFRSF5 [Similar Products]
 UniProt Entry Name    TNR5_HUMAN
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 NCBI Summary for CD40    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD40    Function: Receptor for TNFSF5/CD40LG.

Subunit structure: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Ref.11 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18

Subcellular location: Isoform I: Cell membrane; Single-pass type I membrane protein. Isoform II: Secreted.

Tissue specificity: B-cells and in primary carcinomas.

Involvement in disease: Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities: Contains 4 TNFR-Cys repeats.
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 Research Articles on CD40    1. Activation of CD40 by recombinant soluble CD40 ligand readily induces NF-kappaB activation in cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD40 antibodyDiseases associated with anti-CD40 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2137 publications with CD40 and Necrosis
 Neoplasms Antibodies  >1955 publications with CD40 and Neoplasms
 Inflammation Antibodies  >1455 publications with CD40 and Inflammation
 Cardiovascular Diseases Antibodies  >1016 publications with CD40 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >675 publications with CD40 and Disease Models, Animal
 Atherosclerosis Antibodies  >454 publications with CD40 and Atherosclerosis
 Nervous System Diseases Antibodies  >452 publications with CD40 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >400 publications with CD40 and Neoplasms, Experimental
 Arthritis, Rheumatoid Antibodies  >243 publications with CD40 and Arthritis, Rheumatoid
 Liver Diseases Antibodies  >186 publications with CD40 and Liver Diseases
Organs/Tissues associated with anti-CD40 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8352 publications with CD40 and Blood
 Bone Antibodies  >1191 publications with CD40 and Bone
 Lymph Node Antibodies  >839 publications with CD40 and Lymph Node
 Lymph Antibodies  >655 publications with CD40 and Lymph
 Skin Antibodies  >574 publications with CD40 and Skin
 Lung Antibodies  >396 publications with CD40 and Lung
 Liver Antibodies  >371 publications with CD40 and Liver
 Kidney Antibodies  >347 publications with CD40 and Kidney
 Brain Antibodies  >290 publications with CD40 and Brain
 Tonsil Antibodies  >218 publications with CD40 and Tonsil
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