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anti-CD40LG antibody :: anti-Human CD40L Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312100 anti-CD40LG antibody
Unit / Price
1 mg  /  $710 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD40L (CD40LG), Monoclonal Antibody

 Also Known As   

MAb to CD40L

 Product Synonym Names    Monoclonal Antibody to Human CD40 Ligand
 Product Gene Name   

anti-CD40LG antibody

[Similar Products]
 Matching Pairs    Capture Antibody: CD40L Clone #10A6 (MBS312100)
Detection Antibody: CD40L Clone #2A3 (MBS312101)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (135730336..135742549). Location: Xq26
 OMIM    300386
 3D Structure    ModBase 3D Structure for P29965
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10A6
 Host    Host: Mouse. Hybridization of Sp 2/0 myeloma cells with spleen cells from Balb/c mice.
Source: Ascites
 Species Reactivity    Human
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 Specificity    CD40L
Soluble human CD40L. Can be used for detection of human sCD40L in serum.
 Purity/Purification    >90% pure. Protein A Sepharose chromatography. Purity is tested by electrophoresis.
 Form/Format    Purified, Liquid
 Concentration    4.5mg/ml (Sigma protein assay kit) (lot specific)
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 Immunogen    Recombinant human soluble CD40 Ligand/TRAP Analog conjugates with BSA.
 Affinity Constant    Not determined.
 Buffer    PBS, pH 7.4
 Preservative    0.1% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD40LG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CD40LG antibody    Monoclonal Antibodies to Human CDs
 Applications Tested/Suitable for anti-CD40LG antibody   

EIA/ELISA, Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for CD40LG. It may not necessarily be applicable to this product.
 NCBI GI #    4557433
 NCBI GeneID    959
 NCBI Accession #    NP_000065.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000074.2 [Other Products]
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 UniProt Primary Accession #    P29965 [Other Products]
 UniProt Related Accession #    P29965; Q3L8U2; Q3LFI8; Q45QX2 [Other Products]
 Molecular Weight    29,274 Da [Similar Products]
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 NCBI Official Full Name    CD40 ligand
 NCBI Official Synonym Full Names    CD40 ligand
 NCBI Official Symbol    CD40LG [Similar Products]
 NCBI Official Synonym Symbols   
IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L
[Similar Products]
 NCBI Protein Information    CD40 ligand; CD40-L; OTTHUMP00000024130; OTTHUMP00000024131; CD40 antigen ligand; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5
 UniProt Protein Name    CD40 ligand
 UniProt Synonym Protein Names   
T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5
 Protein Family    CD40 ligand
 UniProt Gene Name    CD40LG [Similar Products]
 UniProt Synonym Gene Names    CD40L; TNFSF5; TRAP [Similar Products]
 UniProt Entry Name    CD40L_HUMAN
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 NCBI Summary for CD40LG    The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq]
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 UniProt Comments for CD40LG    Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Ref.10Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. Ref.10

Subunit structure: Homotrimer.

Subcellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted.

Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes.

Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.Not O-glycosylated. Ref.9

Involvement in disease: Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [

MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. Ref.3 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21

Sequence similarities: Belongs to the tumor necrosis factor family.
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 Research Articles on CD40LG    1. this study demonstrates high CD154 and FAS expression as a characteristic feature of SLE.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD40LG antibodyPathways associated with anti-CD40LG antibody
 Reference Product  PubMed Publications
 CD40 antibody  >14 publications with CD40LG and CD40
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
Diseases associated with anti-CD40LG antibodyOrgans/Tissues associated with anti-CD40LG antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with CD40LG and Inflammation
 Genetic Diseases, Inborn Antibodies  >3 publications with CD40LG and Genetic Diseases, Inborn
 Skin Diseases Antibodies  >2 publications with CD40LG and Skin Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CD40LG and Cardiovascular Diseases
 Vascular Diseases Antibodies  >2 publications with CD40LG and Vascular Diseases
 Myocardial Ischemia Antibodies  >2 publications with CD40LG and Myocardial Ischemia
 Neutropenia Antibodies  >2 publications with CD40LG and Neutropenia
 Neoplasms Antibodies  >2 publications with CD40LG and Neoplasms
 Erythema Antibodies  >1 publications with CD40LG and Erythema
 Peritonitis Antibodies  >1 publications with CD40LG and Peritonitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with CD40LG and Blood
 Mixed Antibodies  >1 publications with CD40LG and Mixed
 Thymus Antibodies  >1 publications with CD40LG and Thymus
 Brain Antibodies  >1 publications with CD40LG and Brain
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