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anti-CD41 antibody :: Rat CD41 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210420
Testing Data
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD41, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD41:Biotin

 Product Gene Name   

anti-CD41 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9QUM0
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MWReg30
 Host    Rat
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 Form/Format    Biotin
Purified IgG conjugated to Biotin - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD41 antibody

   Rat anti Mouse CD41 antibody, clone MWReg30 recognizes the mouse integrin alpha IIb subunit CD41. CD41 is a ~125kDa single pass type 1 transmembrane glycoprotein expressed by platelets, megakaryocytes (Zhang et al. 2007), mast cells (Berlanga et al. 2005)and hematopoietic progenitors (Mitjavila-Garcia et al. 2002). CD41 forms a heterodimer with CD61. The CD41/CD61 complex is important for platelet adhesion and aggregation (Patel et al. 2003) acting as a receptor for many extracellular matrix proteins including fibronectin, thrombospondin and vitronectin (Weisel et al. 1992). Rat anti mouse CD41, clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al. 1999).
 Applications Tested/Suitable for anti-CD41 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD41 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data of anti-CD41 antibody    Staining of mouse peripheral blood with Rat anti Mouse CD41 (MBS212608). Platelets stain strongly for CD41
anti-CD41 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.
 NCBI GI #    159110663
 NCBI GeneID    16399
 NCBI Accession #    NP_034705.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010575.2 [Other Products]
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 UniProt Primary Accession #    Q9QUM0 [Other Products]
 UniProt Secondary Accession #    Q3U3R7; Q64229; Q9Z2M0 [Other Products]
 UniProt Related Accession #    Q9QUM0 [Other Products]
 Molecular Weight    112,678 Da
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 NCBI Official Full Name    integrin alpha-IIb
 NCBI Official Synonym Full Names    integrin alpha 2b
 NCBI Official Symbol    Itga2b [Similar Products]
 NCBI Official Synonym Symbols   
CD41; CD41B; GpIIb; AI172977; alphaIIb
[Similar Products]
 NCBI Protein Information    integrin alpha-IIb; GP IIb; GPalpha IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb
 UniProt Protein Name    Integrin alpha-IIb
 UniProt Synonym Protein Names   
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD_antigen: CD41Cleaved into the following 2 chains:Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain
 UniProt Gene Name    Itga2b [Similar Products]
 UniProt Synonym Gene Names    GPIIb [Similar Products]
 UniProt Entry Name    ITA2B_MOUSE
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 UniProt Comments for CD41    ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Cellular Component: cell surface; focal adhesion; membrane; integral to membrane; integrin complex; external side of plasma membrane

Molecular Function: identical protein binding; extracellular matrix binding; metal ion binding

Biological Process: integrin-mediated signaling pathway; positive regulation of leukocyte migration; cell-matrix adhesion; cell adhesion
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 Research Articles on CD41    1. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD41 antibodyDiseases associated with anti-CD41 antibody
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Thrombasthenia Antibodies  >40 publications with CD41 and Thrombasthenia
 Thrombosis Antibodies  >21 publications with CD41 and Thrombosis
 Cardiovascular Diseases Antibodies  >20 publications with CD41 and Cardiovascular Diseases
 Thrombocytopenia Antibodies  >12 publications with CD41 and Thrombocytopenia
 Heart Diseases Antibodies  >8 publications with CD41 and Heart Diseases
 Stroke Antibodies  >7 publications with CD41 and Stroke
 Inflammation Antibodies  >3 publications with CD41 and Inflammation
 Atherosclerosis Antibodies  >3 publications with CD41 and Atherosclerosis
 Carotid Artery Thrombosis Antibodies  >2 publications with CD41 and Carotid Artery Thrombosis
 Kidney Diseases Antibodies  >2 publications with CD41 and Kidney Diseases
Organs/Tissues associated with anti-CD41 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with CD41 and Blood
 Heart Antibodies  >10 publications with CD41 and Heart
 Bone Antibodies  >10 publications with CD41 and Bone
 Bone Marrow Antibodies  >7 publications with CD41 and Bone Marrow
 Kidney Antibodies  >5 publications with CD41 and Kidney
 Brain Antibodies  >3 publications with CD41 and Brain
 Embryonic Tissue Antibodies  >2 publications with CD41 and Embryonic Tissue
 Spleen Antibodies  >2 publications with CD41 and Spleen
 Thymus Antibodies  >1 publications with CD41 and Thymus
 Inner Ear Antibodies  >1 publications with CD41 and Inner Ear
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