NP_034705.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
112,678 Da
NCBI Official Full Name
integrin alpha-IIb
NCBI Official Synonym Full Names
integrin alpha 2b
NCBI Official Synonym Symbols
CD41; CD41B; GpIIb; AI172977; alphaIIb [Similar Products]
NCBI Protein Information
integrin alpha-IIb; GP IIb; GPalpha IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet membrane glycoprotein IIb
UniProt Protein Name
Integrin alpha-IIb
UniProt Synonym Protein Names
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD_antigen: CD41Cleaved into the following 2 chains:Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain
UniProt Synonym Gene Names
UniProt Entry Name
ITA2B_MOUSE
UniProt Comments for CD41
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: focal adhesion; cell surface; membrane; integral to membrane; integrin complex; external side of plasma membrane
Molecular Function: identical protein binding; extracellular matrix binding; metal ion binding
Biological Process: integrin-mediated signaling pathway; positive regulation of leukocyte migration; cell-matrix adhesion; cell adhesion
Research Articles on CD41
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Pathways associated with anti-CD41 antibody
Diseases associated with anti-CD41 antibody
Organs/Tissues associated with anti-CD41 antibody
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