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anti-CD41 antibody :: Mouse CD41 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213025
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD41, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD41

 Product Gene Name   

anti-CD41 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    187800
 3D Structure    ModBase 3D Structure for P08514
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    PM6/248
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Human platelet plasma membrane
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD41 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD41 antibody

   Mouse anti Human CD41 antibody, clone PM6/248 recognizes the human CD41 cell surface antigen, a 140kD glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF. It has not been established if clone PM6/248 recognizes free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.
 Applications Tested/Suitable for anti-CD41 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD41 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
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 Testing Data of anti-CD41 antibody    Staining of human peripheral blood platelets with Mouse anti Human CD41:RPE (MBS213833)
anti-CD41 antibody Testing Data image
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 Testing Data of anti-CD41 antibody    Staining of human peripheral blood platelets with Mouse anti Human CD41:Alexa Fluor 647
anti-CD41 antibody Testing Data image
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 Testing Data of anti-CD41 antibody    Staining of human peripheral blood platelets with Mouse anti Human CD41:FITC (MBS211023)
anti-CD41 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD41. It may not necessarily be applicable to this product.
 NCBI GI #    88758615
 NCBI GeneID    3674
 NCBI Accession #    NP_000410.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000419.3 [Other Products]
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 UniProt Primary Accession #    P08514 [Other Products]
 UniProt Secondary Accession #    O95366; Q14443; Q17R67; B2RCY8 [Other Products]
 UniProt Related Accession #    P08514 [Other Products]
 Molecular Weight    103,218 Da
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 NCBI Official Full Name    integrin alpha-IIb preproprotein
 NCBI Official Synonym Full Names    integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
 NCBI Official Symbol    ITGA2B [Similar Products]
 NCBI Official Synonym Symbols   
GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
[Similar Products]
 NCBI Protein Information    integrin alpha-IIb; GPalpha IIb; platelet fibrinogen receptor, alpha subunit; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93
 UniProt Protein Name    Integrin alpha-IIb
 UniProt Synonym Protein Names   
GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD_antigen: CD41Cleaved into the following 3 chains:Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2
 UniProt Gene Name    ITGA2B [Similar Products]
 UniProt Synonym Gene Names    GP2B; ITGAB; GPIIb [Similar Products]
 UniProt Entry Name    ITA2B_HUMAN
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 NCBI Summary for CD41    ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD41    ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: platelet alpha granule membrane; cell surface; focal adhesion; integral to plasma membrane; plasma membrane; integrin complex; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; extracellular matrix binding; metal ion binding

Biological Process: integrin-mediated signaling pathway; axon guidance; platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; positive regulation of leukocyte migration; cell-matrix adhesion; blood coagulation; cell adhesion

Disease: Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
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 Research Articles on CD41    1. The genetic polymorphism of GP lIb-Illa (GP Ila Leu33Pro) was not noted to affect platelet aggregation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD41 antibodyPathways associated with anti-CD41 antibody
 Reference Product  PubMed Publications
 ITGB3 antibody  >56 publications with CD41 and ITGB3
 SYK antibody  >2 publications with CD41 and SYK
 FGA antibody  >2 publications with CD41 and FGA
 PTK2 antibody  >1 publications with CD41 and PTK2
 FGG antibody  >1 publications with CD41 and FGG
 FN1 antibody  >1 publications with CD41 and FN1
 COL2A1 antibody  >1 publications with CD41 and COL2A1
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 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
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 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
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Diseases associated with anti-CD41 antibodyOrgans/Tissues associated with anti-CD41 antibody
 Disease Name  Pubmed Publications
 Thrombasthenia Antibodies  >40 publications with CD41 and Thrombasthenia
 Thrombosis Antibodies  >21 publications with CD41 and Thrombosis
 Cardiovascular Diseases Antibodies  >20 publications with CD41 and Cardiovascular Diseases
 Thrombocytopenia Antibodies  >12 publications with CD41 and Thrombocytopenia
 Heart Diseases Antibodies  >8 publications with CD41 and Heart Diseases
 Stroke Antibodies  >7 publications with CD41 and Stroke
 Inflammation Antibodies  >3 publications with CD41 and Inflammation
 Atherosclerosis Antibodies  >3 publications with CD41 and Atherosclerosis
 Carotid Artery Thrombosis Antibodies  >2 publications with CD41 and Carotid Artery Thrombosis
 Kidney Diseases Antibodies  >2 publications with CD41 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >82 publications with CD41 and Blood
 Bone Marrow Antibodies  >7 publications with CD41 and Bone Marrow
 Brain Antibodies  >3 publications with CD41 and Brain
 Spleen Antibodies  >2 publications with CD41 and Spleen
 Embryonic Tissue Antibodies  >2 publications with CD41 and Embryonic Tissue
 Liver Antibodies  >2 publications with CD41 and Liver
 Thymus Antibodies  >1 publications with CD41 and Thymus
 Placenta Antibodies  >1 publications with CD41 and Placenta
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