NP_000165.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,046 Da
NCBI Official Full Name
platelet glycoprotein IX
NCBI Official Synonym Full Names
glycoprotein IX (platelet)
NCBI Official Synonym Symbols
NCBI Protein Information
platelet glycoprotein IX; glycoprotein 9
UniProt Protein Name
Platelet glycoprotein IX
UniProt Synonym Protein Names
Glycoprotein 9; CD_antigen: CD42a
UniProt Synonym Gene Names
UniProt Entry Name
GPIX_HUMAN
NCBI Summary for CD42a
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]
UniProt Comments for CD42a
GPIX: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: platelet activation; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway
Disease: Bernard-soulier Syndrome
Research Articles on CD42a
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Products associated with anti-CD42a antibody
Pathways associated with anti-CD42a antibody
Diseases associated with anti-CD42a antibody
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