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anti-CD42b antibody :: Mouse CD42b Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS216552
Unit / Price
0.025 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD42b, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD42b

 Product Gene Name   

anti-CD42b antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153670
 3D Structure    ModBase 3D Structure for P07359
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    AK2
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD42b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD42b antibody

   Mouse anti Human CD42b antibody, clone AK2 recognizes the human CD42b cell surface antigen, also known as platelet glycoprotein GP1B. CD42b is expressed by platelets and megakaryocytes. Clone AK2 has been reported to block the binding of von Willebrand Factor (VWF) to platelets
 Applications Tested/Suitable for anti-CD42b antibody   

ELISA (EIA), Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD42b antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 100ul whole blood.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
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 Testing Data of anti-CD42b antibody    Staining of human peripheral blood platelets with Mouse anti Human CD42b:FITC (MBS211082)
anti-CD42b antibody Testing Data image
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 Testing Data of anti-CD42b antibody    Staining of human peripheral blood platelets with Mouse anti Human CD42b:RPE (MBS213871)
anti-CD42b antibody Testing Data image
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 Testing Data of anti-CD42b antibody    Staining of human peripheral blood platelets with Mouse anti Human CD42b:Biotin (MBS210512)
anti-CD42b antibody Testing Data image
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 Testing Data of anti-CD42b antibody    Staining of human peripheral blood platelets with Mouse anti Human CD42b (MBS213137)
anti-CD42b antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD42b. It may not necessarily be applicable to this product.
 NCBI GI #    291190772
 NCBI GeneID    2811
 NCBI Accession #    NP_000164.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_000173.6 [Other Products]
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 UniProt Primary Accession #    P07359 [Other Products]
 UniProt Secondary Accession #    Q14441; Q16469; Q8N1F3; Q8NG39; Q9HDC7; Q9UEK1; Q9UQS4; E7ES66 [Other Products]
 UniProt Related Accession #    P07359 [Other Products]
 Molecular Weight    71,540 Da
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 NCBI Official Full Name    platelet glycoprotein Ib alpha chain
 NCBI Official Synonym Full Names    glycoprotein Ib (platelet), alpha polypeptide
 NCBI Official Symbol    GP1BA [Similar Products]
 NCBI Official Synonym Symbols   
BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha
[Similar Products]
 NCBI Protein Information    platelet glycoprotein Ib alpha chain; GP-Ib alpha; antigen CD42b-alpha; platelet membrane glycoprotein 1b-alpha subunit
 UniProt Protein Name    Platelet glycoprotein Ib alpha chain
 UniProt Synonym Protein Names   
Antigen CD42b-alpha; CD_antigen: CD42bGlycocalicin
 UniProt Gene Name    GP1BA [Similar Products]
 UniProt Synonym Gene Names    GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha [Similar Products]
 UniProt Entry Name    GP1BA_HUMAN
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 NCBI Summary for CD42b    Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
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 UniProt Comments for CD42b    GPIbA: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Genetic variations in GP1BA may be a cause of susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). NAION is an ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage. Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia (BMM); also known as autosomal dominant benign Bernard-Soulier syndrome. BMM is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count. Defects in GP1BA are the cause of pseudo-von Willebrand disease (VWDP). A bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation.

Protein type: Cell surface; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; thrombin receptor activity

Biological Process: platelet activation; fibrinolysis; cell surface receptor linked signal transduction; regulation of blood coagulation; cell morphogenesis; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway

Disease: Pseudo-von Willebrand Disease; Bernard-soulier Syndrome; Bernard-soulier Syndrome, Type A2, Autosomal Dominant; Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
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 Research Articles on CD42b    1. The platelet adhesion receptor, the glycoprotein Ib-IX-V complex, not only mediates platelet adhesion but also transmits signals leading to platelet activation, aggregation and secretion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD42b antibodyPathways associated with anti-CD42b antibody
 Reference Product  PubMed Publications
 VWF antibody  >18 publications with CD42b and VWF
 F12 antibody  >5 publications with CD42b and F12
 GP1BB antibody  >5 publications with CD42b and GP1BB
 GP9 antibody  >4 publications with CD42b and GP9
 ITGAM antibody  >1 publications with CD42b and ITGAM
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 GP1b-IX-V Activation Signalling Pathway antibodies  GP1b-IX-V Activation Signalling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Platelet Adhesion To Exposed Collagen Pathway antibodies  Platelet Adhesion To Exposed Collagen Pathway Diagram
 Platelet Aggregation (Plug Formation) Pathway antibodies  Platelet Aggregation (Plug Formation) Pathway Diagram
Diseases associated with anti-CD42b antibodyOrgans/Tissues associated with anti-CD42b antibody
 Disease Name  Pubmed Publications
 Thrombosis Antibodies  >9 publications with CD42b and Thrombosis
 Bernard-Soulier Syndrome Antibodies  >8 publications with CD42b and Bernard-Soulier Syndrome
 Hypertension Antibodies  >6 publications with CD42b and Hypertension
 Von Willebrand disease, platelet type Antibodies  >5 publications with CD42b and Von Willebrand disease, platelet type
 Weight Loss Antibodies  >2 publications with CD42b and Weight Loss
 Chromosome Aberrations Antibodies  >1 publications with CD42b and Chromosome Aberrations
 Respiratory Tract Diseases Antibodies  >1 publications with CD42b and Respiratory Tract Diseases
 Premature Birth Antibodies  >1 publications with CD42b and Premature Birth
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with CD42b and Blood
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