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anti-CD44 antibody :: Mouse CD44 Biotinylated Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140143 anti-CD44 antibody
Unit / Price
0.5 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44 Biotinylated, Monoclonal Antibody

 Also Known As   

Mouse Anti Human CD44 Biotinylated

 Product Synonym Names    CD44 Antibody, Biotin; CD44, Mouse Anti-Human Biotin; MDU2; MDU3; MIC4; CDW44; CSPG8; HCELL; HUTCH-I; Phagocytic glycoprotein I; PGP-1; Extracellular matrix receptor-III; ECMR-III; Hermes antigen; Hyaluronate receptor; Heparan sulfate proteoglycan; Epican) CDw44; CD44 Biotin
 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107269
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    hCD44
 Host    Mouse
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 Purity/Purification    Protein-A.
 Concentration    1mg/ml in PBS (after reconstitution). (lot specific)
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 Reconstitution    Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    Purified human T-Cells.
 Antibody Properties    Staining antibody. For staining, use 5-10 ul/1,000,000 cells.
 Available Conjugates    This antibody is also available conjugated to biotin and FITC. For staining with biotin or FITC-conjugated antibody use 5-10 ul/106 cells.
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 Preparation and Storage    Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD44 antibody

   Introduction: CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such as lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. Increased CD44 antigen is associated with relapses in non-small cell lung cancers.
 Product Categories/Family for anti-CD44 antibody    MONOCLONAL ANTIBODIES, ANTI-HUMAN LYMPHOCYTES; Monoclonal Antibodies; Anti Human Lymphocyte
NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    48255935
 NCBI GeneID    960
 NCBI Accession #    NP_000601.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000610.3 [Other Products]
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 UniProt Secondary Accession #    O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; A5YRN9; B6EAT9; D3DR12; D3DR13 [Other Products]
 UniProt Related Accession #    P16070 [Other Products]
 Molecular Weight    15,635 Da
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 NCBI Official Full Name    CD44 antigen isoform 1
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    CD44 [Similar Products]
 NCBI Official Synonym Symbols   
IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
[Similar Products]
 NCBI Protein Information    CD44 antigen; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; epican; extracellular matrix receptor III; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; homing function and Indian blood group system; hyaluronate receptor; phagocytic glycoprotein 1
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
 Protein Family    CD44 antigen
 UniProt Gene Name    CD44 [Similar Products]
 UniProt Synonym Gene Names    LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I [Similar Products]
 UniProt Entry Name    CD44_HUMAN
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 NCBI Summary for CD44    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: Golgi apparatus; focal adhesion; cell surface; basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; extracellular matrix disassembly; cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; healing during inflammatory response; hyaluronan metabolic process; negative regulation of apoptosis

Disease: Blood Group, Indian System
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 Research Articles on CD44    1. CD44v6 expression, serum prostate-specific antigen level, and surgical margin status appeared to be independently associated with biochemical recurrence of prostate neoplasms on multivariate analysis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD44 antibodyDiseases associated with anti-CD44 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2014 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >1145 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >1050 publications with CD44 and Skin Diseases
 Breast Neoplasms Antibodies  >876 publications with CD44 and Breast Neoplasms
 Inflammation Antibodies  >839 publications with CD44 and Inflammation
 Disease Models, Animal Antibodies  >676 publications with CD44 and Disease Models, Animal
 Necrosis Antibodies  >505 publications with CD44 and Necrosis
 Neoplasms, Experimental Antibodies  >503 publications with CD44 and Neoplasms, Experimental
 Lung Diseases Antibodies  >502 publications with CD44 and Lung Diseases
 Nervous System Diseases Antibodies  >408 publications with CD44 and Nervous System Diseases
Organs/Tissues associated with anti-CD44 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4088 publications with CD44 and Blood
 Bone Antibodies  >1584 publications with CD44 and Bone
 Bone Marrow Antibodies  >1214 publications with CD44 and Bone Marrow
 Vascular Antibodies  >1082 publications with CD44 and Vascular
 Lymph Node Antibodies  >989 publications with CD44 and Lymph Node
 Lung Antibodies  >815 publications with CD44 and Lung
 Liver Antibodies  >697 publications with CD44 and Liver
 Spleen Antibodies  >594 publications with CD44 and Spleen
 Embryonic Tissue Antibodies  >564 publications with CD44 and Embryonic Tissue
 Skin Antibodies  >563 publications with CD44 and Skin
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