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anti-CD44 antibody :: Mouse CD44 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213108
Unit / Price
0.25 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44, Monoclonal Antibody

 Also Known As   

MOUSE ANTI RAT CD44

 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P26051
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    OX-50
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD44 antibody

   Mouse anti Rat CD44 antibody, clone OX-50 recognizes the rat CD44 cell surface antigen, expressed by T cells, B cells, macrophages and thymocytes. CD44 is a glycoprotein of 85kD, with expression being increased following activation.
 Applications Tested/Suitable for anti-CD44 antibody   

Immunohistology Frozen*, Flow cytometry (FC/FACS)

 Application Notes for anti-CD44 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
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 Testing Data of anti-CD44 antibody    Staining of rat spleen cells with Mouse anti Rat CD44:FITC (MBS211070)
anti-CD44 antibody Testing Data image
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 Testing Data of anti-CD44 antibody    Staining of rat spleen cells with Mouse anti Rat CD44: FITC (MBS211069)
anti-CD44 antibody Testing Data image
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 Testing Data of anti-CD44 antibody    Staining of rat spleen cells with Mouse anti Rat CD44 (MBS219235)
anti-CD44 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    564342041
 NCBI GeneID    25406
 NCBI Accession #    XP_006234693.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_006234631.2 [Other Products]
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 UniProt Primary Accession #    P26051 [Other Products]
 UniProt Secondary Accession #    Q99021 [Other Products]
 UniProt Related Accession #    P26051 [Other Products]
 Molecular Weight    39,794 Da
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 NCBI Official Full Name    CD44 antigen isoform X7
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    Cd44 [Similar Products]
 NCBI Official Synonym Symbols   
CD44A; METAA; RHAMM
[Similar Products]
 NCBI Protein Information    CD44 antigen; Cell surface glycoprotein CD44 (hyaluronate binding protein); ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; PGP-1; PGP-I; extracellular matrix receptor III; hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; phagocytic glycoprotein I
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
 Protein Family    CD44 antigen
 UniProt Gene Name    Cd44 [Similar Products]
 UniProt Synonym Gene Names    ECMR-III; PGP-1; PGP-I [Similar Products]
 UniProt Entry Name    CD44_RAT
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 NCBI Summary for CD44    adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion

Cellular Component: Golgi apparatus; focal adhesion; protein complex; cell surface; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding

Biological Process: cell migration; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; response to organic cyclic substance; positive regulation of peptidyl-serine phosphorylation; blood vessel maturation; response to vitamin A; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; cartilage development; regulation of cell growth; inflammatory response; cell adhesion; healing during inflammatory response; neurite development; negative regulation of apoptosis
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 Research Articles on CD44    1. Altered fetal expression of the osteopontin-CD44-integrin-receptor-system in the MWF mutant nephron deficit model points to a possible role in low nephron number hypertension and cardiovascular disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD44 antibodyDiseases associated with anti-CD44 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2013 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >1143 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >1049 publications with CD44 and Skin Diseases
 Breast Neoplasms Antibodies  >875 publications with CD44 and Breast Neoplasms
 Inflammation Antibodies  >838 publications with CD44 and Inflammation
 Disease Models, Animal Antibodies  >675 publications with CD44 and Disease Models, Animal
 Necrosis Antibodies  >505 publications with CD44 and Necrosis
 Lung Diseases Antibodies  >502 publications with CD44 and Lung Diseases
 Neoplasms, Experimental Antibodies  >502 publications with CD44 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >408 publications with CD44 and Nervous System Diseases
Organs/Tissues associated with anti-CD44 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >814 publications with CD44 and Lung
 Spleen Antibodies  >594 publications with CD44 and Spleen
 Thymus Antibodies  >504 publications with CD44 and Thymus
 Brain Antibodies  >499 publications with CD44 and Brain
 Connective Tissue Antibodies  >406 publications with CD44 and Connective Tissue
 Prostate Antibodies  >346 publications with CD44 and Prostate
 Kidney Antibodies  >316 publications with CD44 and Kidney
 Adipose Tissue Antibodies  >229 publications with CD44 and Adipose Tissue
 Heart Antibodies  >223 publications with CD44 and Heart
 Eye Antibodies  >177 publications with CD44 and Eye
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