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anti-CD44 antibody :: Mouse anti-Human CD44 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245495
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone MEM-85] (IgG2b) to Human CD44

 Product Synonym Names    Anti-CD44 Antibody (clone MEM-85) IHC-plus; CD44; CDW44; CD44 antigen; Cell surface glycoprotein CD44; CSPG8; ECMR-III; Epican; HUTCH-I; LHR; MDU2; MC56; MIC4; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; PGP-I; Pgp1; Phagocytic glycoprotein I; MDU3; CD44R; HCELL; Human CD44
 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609027
 3D Structure    ModBase 3D Structure for P16070
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    MEM-85
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Reacts with both cell surface-expressed and soluble form of CD44 antigen (Phagocyte glycoprotein 1), a 80-95 kD transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.
 Purity/Purification    Protein A Purified
 Form/Format    PBS, 15 mM sodium azide, approx., pH 7.4.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Leukocytes of a patient suffering from LGL Type Leukaemia.
 Immunogen    CD44 antibody was raised against leukocytes of a patient suffering from LGL Type Leukaemia.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD44 antibody

   CD44 is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.
 Applications Tested/Suitable for anti-CD44 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-CD44 antibody    ELISA, Flo, IHC-P (5 ug/ml), IP, WB (2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD44 antibody    Anti-CD44 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CD44 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    48255935
 NCBI GeneID    960
 NCBI Accession #    NP_000601.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000610.3 [Other Products]
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 UniProt Primary Accession #    P16070 [Other Products]
 UniProt Secondary Accession #    O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; A5YRN9; B6EAT9; D3DR12; D3DR13 [Other Products]
 UniProt Related Accession #    P16070 [Other Products]
 Molecular Weight    15,635 Da
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 NCBI Official Full Name    CD44 antigen isoform 1
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    CD44 [Similar Products]
 NCBI Official Synonym Symbols   
IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
[Similar Products]
 NCBI Protein Information    CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
 Protein Family    CD44 antigen
 UniProt Gene Name    CD44 [Similar Products]
 UniProt Synonym Gene Names    LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I [Similar Products]
 UniProt Entry Name    CD44_HUMAN
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 NCBI Summary for CD44    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: Golgi apparatus; cell surface; focal adhesion; basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; extracellular matrix disassembly; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; hyaluronan metabolic process; healing during inflammatory response; negative regulation of apoptosis

Disease: Blood Group, Indian System
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 Research Articles on CD44    1. CD44v6+, CD44v9+ and CD44s- were associated with pancreatic carcinoma metastasis and progression and that CD44v6+/CD44s- was an independent risk factor affecting survival in pancreatic carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD44 antibodyDiseases associated with anti-CD44 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >1982 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >1121 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >1035 publications with CD44 and Skin Diseases
 Breast Neoplasms Antibodies  >861 publications with CD44 and Breast Neoplasms
 Inflammation Antibodies  >829 publications with CD44 and Inflammation
 Disease Models, Animal Antibodies  >658 publications with CD44 and Disease Models, Animal
 Necrosis Antibodies  >499 publications with CD44 and Necrosis
 Lung Diseases Antibodies  >492 publications with CD44 and Lung Diseases
 Neoplasms, Experimental Antibodies  >491 publications with CD44 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >403 publications with CD44 and Nervous System Diseases
Organs/Tissues associated with anti-CD44 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4059 publications with CD44 and Blood
 Bone Antibodies  >1567 publications with CD44 and Bone
 Bone Marrow Antibodies  >1203 publications with CD44 and Bone Marrow
 Vascular Antibodies  >1072 publications with CD44 and Vascular
 Lymph Node Antibodies  >979 publications with CD44 and Lymph Node
 Lung Antibodies  >803 publications with CD44 and Lung
 Liver Antibodies  >686 publications with CD44 and Liver
 Spleen Antibodies  >590 publications with CD44 and Spleen
 Skin Antibodies  >561 publications with CD44 and Skin
 Embryonic Tissue Antibodies  >555 publications with CD44 and Embryonic Tissue
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