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anti-CD44 antibody :: Mouse anti-Rat CD44 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531171 anti-CD44 antibody
Unit / Price
0.25 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44, Monoclonal Antibody

 Also Known As   

CD44 antibody

 Product Synonym Names    Monoclonal CD44; Anti-CD44; CD-44; H-CAM; CD 44; CD44; HCAM; Pgp1; ECMR-III; cell surface glycoprotein CD44; MGC10468; MDU2; phagocytic glycoprotein 1; MDU3; MIC4; CSPG8; LHR; CD44 antigen; Hermes antigen; IN
 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O08779
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    MRC OX-49
 Host    Mouse
 Species Reactivity    Rat
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 Form/Format    Protein G affinity purified and supplied in PBS, with 0.02% NaN3.
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 Biological Significance    The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs).
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    CD44 antibody was raised in mouse using T-cell blasts as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD44 antibody

   Mouse monoclonal CD44 antibody
 Product Categories/Family for anti-CD44 antibody    Differentiation & Development
 Applications Tested/Suitable for anti-CD44 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-CD44 antibody    FC: 10^6 cells/100 ul
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NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    19923703
 NCBI GeneID    25406
 NCBI Accession #    NP_037056.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012924.2 [Other Products]
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 UniProt Primary Accession #    O08779 [Other Products]
 UniProt Related Accession #    P26051 [Other Products]
 Molecular Weight    85,918 Da
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 NCBI Official Full Name    CD44 antigen
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    Cd44 [Similar Products]
 NCBI Official Synonym Symbols   
CD44A; METAA; RHAMM
[Similar Products]
 NCBI Protein Information    CD44 antigen
 UniProt Protein Name    CD44 protein
 UniProt Synonym Protein Names   
CD44 protein
 Protein Family    CD44 antigen
 UniProt Gene Name    Cd44 [Similar Products]
 UniProt Entry Name    O08779_RAT
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 NCBI Summary for CD44    adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: Golgi apparatus; protein complex; cell surface; focal adhesion; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; epidermal growth factor receptor binding; hyalurononglucosaminidase activity

Biological Process: cell migration; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; response to organic cyclic substance; positive regulation of peptidyl-serine phosphorylation; blood vessel maturation; hyaluronan catabolic process; response to vitamin A; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; cartilage development; regulation of cell growth; cell adhesion; inflammatory response; healing during inflammatory response; neurite development; negative regulation of apoptosis
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 Research Articles on CD44    1. Data show that hyaluronan receptor CD44 undergoes co-internalization with hyaluronan endocytosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD44 antibodyPathways associated with anti-CD44 antibody
 Reference Product  PubMed Publications
 Erbb2 antibody  >160 publications with CD44 and Erbb2
 Spp1 antibody  >129 publications with CD44 and Spp1
 Mmp9 antibody  >38 publications with CD44 and Mmp9
 Hyal2 antibody  >33 publications with CD44 and Hyal2
 Mmp7 antibody  >23 publications with CD44 and Mmp7
 Nf2 antibody  >20 publications with CD44 and Nf2
 Spn antibody  >7 publications with CD44 and Spn
 Sele antibody  >2 publications with CD44 and Sele
 Slc9a1 antibody  >1 publications with CD44 and Slc9a1
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD44 antibodyOrgans/Tissues associated with anti-CD44 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2086 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >1184 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >1098 publications with CD44 and Skin Diseases
 Breast Neoplasms Antibodies  >920 publications with CD44 and Breast Neoplasms
 Inflammation Antibodies  >869 publications with CD44 and Inflammation
 Disease Models, Animal Antibodies  >695 publications with CD44 and Disease Models, Animal
 Lung Diseases Antibodies  >522 publications with CD44 and Lung Diseases
 Neoplasms, Experimental Antibodies  >520 publications with CD44 and Neoplasms, Experimental
 Necrosis Antibodies  >518 publications with CD44 and Necrosis
 Lung Neoplasms Antibodies  >415 publications with CD44 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >847 publications with CD44 and Lung
 Spleen Antibodies  >595 publications with CD44 and Spleen
 Brain Antibodies  >520 publications with CD44 and Brain
 Thymus Antibodies  >508 publications with CD44 and Thymus
 Connective Tissue Antibodies  >432 publications with CD44 and Connective Tissue
 Prostate Antibodies  >354 publications with CD44 and Prostate
 Kidney Antibodies  >331 publications with CD44 and Kidney
 Adipose Tissue Antibodies  >249 publications with CD44 and Adipose Tissue
 Heart Antibodies  >229 publications with CD44 and Heart
 Eye Antibodies  >182 publications with CD44 and Eye
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