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anti-CD44 antibody :: Mouse anti-Chicken CD44 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532244 anti-CD44 antibody
Unit / Price
0.1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD44 antibody (PE)

 Product Synonym Names    Monoclonal CD44; Anti-CD44; CD 44; CD44; Hyaluronate receptor; MDU3; Pgp-1; Hermes; CD-44; MGC10468; MDU2; phagocytic glycoprotein 1; MIC4; CSPG8; LHR; CD44 antigen; Hermes antigen; IN
 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107269
 3D Structure    ModBase 3D Structure for P16070
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    AV6
 Host    Mouse
 Species Reactivity    Chicken
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.1 mg/ml (lot specific)
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 Biological Significance    The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    PE
 Immunogen    CD44 antibody (PE) was raised in mouse using chicken CD44 as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD44 antibody

   Mouse monoclonal CD44 antibody (PE)
 Product Categories/Family for anti-CD44 antibody    Differentiation & Development ; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD44 antibody   

Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    685122
 NCBI GeneID    960
 NCBI Accession #    AAB30429.1 [Other Products]
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 UniProt Primary Accession #    P16070 [Other Products]
 UniProt Secondary Accession #    O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; A5YRN9; B6EAT9; D3DR12; D3DR13 [Other Products]
 UniProt Related Accession #    P16070 [Other Products]
 Molecular Weight    15,635 Da
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 NCBI Official Full Name    CD44, partial
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    CD44 [Similar Products]
 NCBI Official Synonym Symbols   
IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
[Similar Products]
 NCBI Protein Information    CD44 antigen
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
 Protein Family    CD44 antigen
 UniProt Gene Name    CD44 [Similar Products]
 UniProt Synonym Gene Names    LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I [Similar Products]
 UniProt Entry Name    CD44_HUMAN
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 NCBI Summary for CD44    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: Golgi apparatus; cell surface; focal adhesion; basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; extracellular matrix disassembly; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; hyaluronan metabolic process; healing during inflammatory response; negative regulation of apoptosis

Disease: Blood Group, Indian System
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 Research Articles on CD44    1. CD44 could be a valuable tool for the study of lung CSCs and provide a novel therapeutic target for treatment of the patients with lung cancer in combination with conventional therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD44 antibodyDiseases associated with anti-CD44 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2086 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >1184 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >1098 publications with CD44 and Skin Diseases
 Breast Neoplasms Antibodies  >920 publications with CD44 and Breast Neoplasms
 Inflammation Antibodies  >869 publications with CD44 and Inflammation
 Disease Models, Animal Antibodies  >695 publications with CD44 and Disease Models, Animal
 Lung Diseases Antibodies  >522 publications with CD44 and Lung Diseases
 Neoplasms, Experimental Antibodies  >520 publications with CD44 and Neoplasms, Experimental
 Necrosis Antibodies  >518 publications with CD44 and Necrosis
 Lung Neoplasms Antibodies  >415 publications with CD44 and Lung Neoplasms
Organs/Tissues associated with anti-CD44 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4162 publications with CD44 and Blood
 Bone Antibodies  >1634 publications with CD44 and Bone
 Bone Marrow Antibodies  >1247 publications with CD44 and Bone Marrow
 Vascular Antibodies  >1110 publications with CD44 and Vascular
 Lymph Node Antibodies  >1012 publications with CD44 and Lymph Node
 Lung Antibodies  >847 publications with CD44 and Lung
 Liver Antibodies  >721 publications with CD44 and Liver
 Spleen Antibodies  >595 publications with CD44 and Spleen
 Embryonic Tissue Antibodies  >579 publications with CD44 and Embryonic Tissue
 Skin Antibodies  >574 publications with CD44 and Skin
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