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anti-CD44 antibody :: Mouse anti-Chicken CD44 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673970 anti-CD44 antibody
Unit / Price
0.5 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44, Monoclonal Antibody

 Also Known As   

Mouse Anti-Chicken CD44-BIOT

 Product Synonym Names    Mouse Anti-Chicken CD44 - Biotin; Mouse Anti-Chicken CD44
 Product Gene Name   

anti-CD44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (35160417..35253949). Location: 11p13
 3D Structure    ModBase 3D Structure for O95370
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 Clonality    Monoclonal
 Isotype    Mouse IgG1 kappa
 Clone Number    AV6
 Host    Mouse
 Species Reactivity    Chicken
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 Specificity    Chicken CD44 (Mr 90-kDa).
Chicken CD44 is a type I transmembrane glycoprotein expressed on many cell types, including B cells, most T cells, monocytes and some epithelial cells.1 CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development.2,3 MAb AV6 also reacts with IgM+ turkey B cells and a subset of turkey T lymphocytes.4
 Form/Format    Biotin (BIOT) Conjugate
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 Characterization    To ensure optimal performance, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative flow data are shown on page 2 of this product insert.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) and allophycocyanin (APC) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-CD44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD44 antibody   

Flow Cytometry; Immunoprecipitation

 Application Notes for anti-CD44 antibody    Flow Cytometry Suggested Dilution: <= 1 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for CD44. It may not necessarily be applicable to this product.
 NCBI GI #    685122
 NCBI GeneID    960
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 UniProt Primary Accession #    O95370 [Other Products]
 UniProt Related Accession #    O95370; P16070; Q86UZ1; Q99900; Q9H5A3; Q9H5A4; Q9H5A6; Q9H5A7; Q9P2Z2 [Other Products]
 Molecular Weight    15,635 Da [Similar Products]
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 NCBI Official Full Name    CD44
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    CD44 [Similar Products]
 NCBI Official Synonym Symbols   
IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; MGC10468
[Similar Products]
 NCBI Protein Information    CD44 antigen; epican; Hermes antigen; OTTHUMP00000232487; OTTHUMP00000232488; OTTHUMP00000232489; OTTHUMP00000232491; OTTHUMP00000232492; OTTHUMP00000232493; OTTHUMP00000232494; OTTHUMP00000232495; OTTHUMP00000232522; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system
 UniProt Protein Name    CD44 antigen (Indian blood group), isoform CRA_g
 Protein Family    CD44 antigen
 UniProt Gene Name    CD44 [Similar Products]
 UniProt Entry Name    O95370_HUMAN
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 NCBI Summary for CD44    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]
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 UniProt Comments for CD44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: Golgi apparatus; focal adhesion; cell surface; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity

Biological Process: extracellular matrix organization and biogenesis; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; extracellular matrix disassembly; cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; healing during inflammatory response; hyaluronan metabolic process; negative regulation of apoptosis

Disease: Blood Group, Indian System
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Product References and Citations for anti-CD44 antibody

   1. Davison, T.F. Personal Communication.
2. Lazaar, A. L., and E. Pure. 1995. The Immunologist 3:19.
3. Pure, E., R.L. Camp, D. Peritt, P.A. Panettieri, A.L. Lazaar and S. Nayak. 1995. Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. J. Exp. Med. 181:55-62.
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 Research Articles on CD44    1. PKC activation can up-regulate CD44 expression by phosphorylation in human erythrocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD44 antibodyPathways associated with anti-CD44 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >1169 publications with CD44 and CD4
 EGFR antibody  >122 publications with CD44 and EGFR
 SPP1 antibody  >108 publications with CD44 and SPP1
 FGF2 antibody  >61 publications with CD44 and FGF2
 LCK antibody  >46 publications with CD44 and LCK
 VCAN antibody  >24 publications with CD44 and VCAN
 CD74 antibody  >21 publications with CD44 and CD74
 FYN antibody  >18 publications with CD44 and FYN
 NF2 antibody  >15 publications with CD44 and NF2
 MMP9 antibody  >15 publications with CD44 and MMP9
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Osteopontin-mediated Events Pathway antibodies  Osteopontin-mediated Events Pathway Diagram
 Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway antibodies  Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway Diagram
Diseases associated with anti-CD44 antibodyOrgans/Tissues associated with anti-CD44 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3356 publications with CD44 and Neoplasms
 Carcinoma Antibodies  >1354 publications with CD44 and Carcinoma
 Neoplasm Metastasis Antibodies  >803 publications with CD44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >662 publications with CD44 and Skin Diseases
 Inflammation Antibodies  >605 publications with CD44 and Inflammation
 Adenocarcinoma Antibodies  >593 publications with CD44 and Adenocarcinoma
 Breast Neoplasms Antibodies  >502 publications with CD44 and Breast Neoplasms
 Neuroectodermal Tumors Antibodies  >400 publications with CD44 and Neuroectodermal Tumors
 Lung Diseases Antibodies  >363 publications with CD44 and Lung Diseases
 Leukemia Antibodies  >356 publications with CD44 and Leukemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3401 publications with CD44 and Blood
 Bone Antibodies  >1119 publications with CD44 and Bone
 Bone Marrow Antibodies  >885 publications with CD44 and Bone Marrow
 Vascular Antibodies  >835 publications with CD44 and Vascular
 Lymph Node Antibodies  >823 publications with CD44 and Lymph Node
 Lung Antibodies  >579 publications with CD44 and Lung
 Spleen Antibodies  >515 publications with CD44 and Spleen
 Liver Antibodies  >497 publications with CD44 and Liver
 Thymus Antibodies  >468 publications with CD44 and Thymus
 Skin Antibodies  >462 publications with CD44 and Skin
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