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anti-Cd44 antibody :: Mouse anti-Human CD44V7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602260 anti-Cd44 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44V7, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD44V7 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)

 Product Synonym Names    Anti -CD44V7 (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)
 Product Gene Name   

anti-Cd44 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000068.7 (102811141..102901665, complement). Location: 2 E2; 2 54.13 cM
 3D Structure    ModBase 3D Structure for P15379
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3H1353
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes an epitope encoded by exon v7 on the variant portion of human CD44.
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in PBS, 0.01% thimerosal.
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 Immunogen    Glutathione S Transferase (GST) fusion protein corresponding to the variable domains (v3 to v10) of human CD44
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Cd44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cd44 antibody

   Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (>15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 11 (so-called v7) is responsible for tumor progression and metastasis. In fact, CD44v7 expression has been used as an indicator of metastasis.
 Product Categories/Family for anti-Cd44 antibody    Antibodies; Abs to CD Markers
 Applications Tested/Suitable for anti-Cd44 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-Cd44 antibody    Suitable for us ein Flow Cytometry, Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (frozen): 1:50
Immunohistochemistry (paraffin): 1:50 Requires antigen retrieval using heat treatment prior to staining paraffin sections. Sodium citrate buffer, pH 6.0 is recommended.
Flow Cytometry: 1:50. Use 10ul of the suggested working dilution to label 10e6 cells in 100ul.
Optimal working dilutions to be determined by researcher.
Immunohistochemistry Positive Control:
Skin
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NCBI/Uniprot data below describe general gene information for Cd44. It may not necessarily be applicable to this product.
 NCBI GI #    30316353
 NCBI GeneID    12505
 NCBI Accession #    P15379.3 [Other Products]
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 UniProt Primary Accession #    P15379 [Other Products]
 UniProt Secondary Accession #    Q05732; Q61395; Q62060; Q62061; Q62062; Q62063; Q62408; Q62409; Q64296; Q99J14; Q9QYX8 [Other Products]
 UniProt Related Accession #    P15379 [Other Products]
 Molecular Weight    85,617 Da [Similar Products]
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 NCBI Official Full Name    CD44 antigen
 NCBI Official Synonym Full Names    CD44 antigen
 NCBI Official Symbol    Cd44 [Similar Products]
 NCBI Official Synonym Symbols   
Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
[Similar Products]
 NCBI Protein Information    CD44 antigen; PGP-I; HUTCH-I; ECMR-III; hermes antigen; hyaluronate receptor; lymphocyte antigen 24; phagocytic glycoprotein 1; phagocytic glycoprotein I; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Lymphocyte antigen 24; Ly-24; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I
 Protein Family    CD44 antigen
 UniProt Gene Name    Cd44 [Similar Products]
 UniProt Synonym Gene Names    Ly-24; ECMR-III; Ly-24; PGP-1; PGP-I [Similar Products]
 UniProt Entry Name    CD44_MOUSE
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 UniProt Comments for Cd44    CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral

Cellular Component: Golgi apparatus; protein complex; focal adhesion; cell surface; membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding

Biological Process: cell migration; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; positive regulation of adaptive immune response; neurite development; negative regulation of apoptosis
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 Research Articles on Cd44    1. These in vitro and in vivo data suggest that CD44 may be crucial not only for NPC crossing the endothelial layer but also for facilitating invasion of extravascular tissues
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Cd44 antibodyDiseases associated with anti-Cd44 antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4241 publications with Cd44 and Neoplasms
 Carcinoma Antibodies  >1716 publications with Cd44 and Carcinoma
 Neoplasm Metastasis Antibodies  >995 publications with Cd44 and Neoplasm Metastasis
 Skin Diseases Antibodies  >895 publications with Cd44 and Skin Diseases
 Inflammation Antibodies  >744 publications with Cd44 and Inflammation
 Breast Neoplasms Antibodies  >723 publications with Cd44 and Breast Neoplasms
 Disease Models, Animal Antibodies  >583 publications with Cd44 and Disease Models, Animal
 Necrosis Antibodies  >466 publications with Cd44 and Necrosis
 Neoplasms, Experimental Antibodies  >439 publications with Cd44 and Neoplasms, Experimental
 Lung Diseases Antibodies  >436 publications with Cd44 and Lung Diseases
Organs/Tissues associated with anti-Cd44 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3824 publications with Cd44 and Blood
 Bone Antibodies  >1416 publications with Cd44 and Bone
 Bone Marrow Antibodies  >1096 publications with Cd44 and Bone Marrow
 Lymph Node Antibodies  >921 publications with Cd44 and Lymph Node
 Lung Antibodies  >707 publications with Cd44 and Lung
 Liver Antibodies  >618 publications with Cd44 and Liver
 Spleen Antibodies  >568 publications with Cd44 and Spleen
 Skin Antibodies  >529 publications with Cd44 and Skin
 Embryonic Tissue Antibodies  >503 publications with Cd44 and Embryonic Tissue
 Thymus Antibodies  >489 publications with Cd44 and Thymus
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