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anti-CD44v4 antibody :: Rabbit CD44v4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380359
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD44v4, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD44v4 (Marker of Tumor Metastasis)

 Product Synonym Names    LHR; BA-1; chondroitin sulfate proteoglycan 8 (CSPG8); Epican; Extracellular Matrix Receptor III (ECM III); GP90 Lymphocyte Homing Adhesion Receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan Sulfate Proteoglycan; Hermes Antigen; HAS; HUTCH I; Hyaluronate Receptor; Indian blood group; Inlu Related p80 Glycoprotein; Ly 24; MDU2; MDU3; MIC4; MUTCH I; Phagocytic Glycoprotein 1 (PGP-1)
 Product Gene Name   

anti-CD44v4 antibody

[Similar Products]
 Product Synonym Gene Name    CD44 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P16070
 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    CD44v4/1700R
 Host    Rabbit
 Species Reactivity    Human. Others not tested.
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 Specificity    This antibody recognizes an epitope encoded by exon v4 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.
 Form/Format    200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant fragment corresponding to the v4 domain of human CD44
 Cellular Localization    Cell Surface
 Hu-chromosome Location    11p13
 Positive Control    Cervix or Tongue Squamous Cell Carcinoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-CD44v4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD44v4 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-CD44v4 antibody    FC/FACS: 0.5-1ug/million cells
IF: 0.5-1ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-CD44v4 antibody    Formalin-fixed, paraffin-embedded human Cervical Squamous Cell Carcinoma stained with CD44v4 Rabbit Recombinant Monoclonal Antibody (CD44v4/1700R).
anti-CD44v4 antibody Immunohistochemistry (IHC) (IHC) image
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 SDS-Page of anti-CD44v4 antibody    SDS-PAGE Analysis of Purified CD44v4 Rabbit Recombinant Monoclonal Antibody (CD44v4/1700R).
anti-CD44v4 antibody SDS-Page image
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NCBI/Uniprot data below describe general gene information for CD44v4. It may not necessarily be applicable to this product.
 NCBI GI #    48255935
 NCBI GeneID    960
 NCBI Accession #    NP_000601.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000610.3 [Other Products]
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 UniProt Primary Accession #    P16070 [Other Products]
 UniProt Secondary Accession #    O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; A5YRN9; B6EAT9; D3DR12; D3DR13 [Other Products]
 UniProt Related Accession #    P16070 [Other Products]
 Molecular Weight    80-95kDa
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 NCBI Official Full Name    CD44 antigen isoform 1
 NCBI Official Synonym Full Names    CD44 molecule (Indian blood group)
 NCBI Official Symbol    CD44 [Similar Products]
 NCBI Official Synonym Symbols   
IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III
[Similar Products]
 NCBI Protein Information    CD44 antigen
 UniProt Protein Name    CD44 antigen
 UniProt Synonym Protein Names   
CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD_antigen: CD44
 UniProt Gene Name    CD44 [Similar Products]
 UniProt Synonym Gene Names    LHR; MDU2; MDU3; MIC4; ECMR-III; PGP-1; PGP-I [Similar Products]
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 NCBI Summary for CD44v4    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD44v4    Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function ().
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Product References and Citations for anti-CD44v4 antibody

   Thanakit V, Sampatanukul P, Ruangvejvorachai P, Keelawat S. The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients. J Med Assoc Thai.2005 Sep; 88 Suppl 4:S30-5.
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 Research Articles on CD44v4    1. CD44 standard isoform was especially upregulated after high-dose X-ray irradiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD44v4 antibodyPathways associated with anti-CD44v4 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >1211 publications with CD44v4 and CD4
 EGFR antibody  >143 publications with CD44v4 and EGFR
 SPP1 antibody  >112 publications with CD44v4 and SPP1
 FGF2 antibody  >68 publications with CD44v4 and FGF2
 LCK antibody  >48 publications with CD44v4 and LCK
 VCAN antibody  >26 publications with CD44v4 and VCAN
 CD74 antibody  >23 publications with CD44v4 and CD74
 MMP9 antibody  >22 publications with CD44v4 and MMP9
 FYN antibody  >18 publications with CD44v4 and FYN
 NF2 antibody  >16 publications with CD44v4 and NF2
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
Diseases associated with anti-CD44v4 antibodyOrgans/Tissues associated with anti-CD44v4 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4120 publications with CD44v4 and Neoplasms
 Carcinoma Antibodies  >1658 publications with CD44v4 and Carcinoma
 Skin Diseases Antibodies  >869 publications with CD44v4 and Skin Diseases
 Inflammation Antibodies  >723 publications with CD44v4 and Inflammation
 Breast Neoplasms Antibodies  >702 publications with CD44v4 and Breast Neoplasms
 Disease Models, Animal Antibodies  >567 publications with CD44v4 and Disease Models, Animal
 Necrosis Antibodies  >457 publications with CD44v4 and Necrosis
 Neoplasms, Experimental Antibodies  >429 publications with CD44v4 and Neoplasms, Experimental
 Lung Diseases Antibodies  >418 publications with CD44v4 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >385 publications with CD44v4 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3769 publications with CD44v4 and Blood
 Bone Antibodies  >1372 publications with CD44v4 and Bone
 Bone Marrow Antibodies  >1065 publications with CD44v4 and Bone Marrow
 Vascular Antibodies  >954 publications with CD44v4 and Vascular
 Lymph Node Antibodies  >910 publications with CD44v4 and Lymph Node
 Lung Antibodies  >682 publications with CD44v4 and Lung
 Liver Antibodies  >603 publications with CD44v4 and Liver
 Spleen Antibodies  >559 publications with CD44v4 and Spleen
 Skin Antibodies  >518 publications with CD44v4 and Skin
 Embryonic Tissue Antibodies  >490 publications with CD44v4 and Embryonic Tissue
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