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anti-CD45 antibody :: Mouse anti-Chicken CD45 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532451 anti-CD45 antibody
Unit / Price
0.5 mg  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD45, Monoclonal Antibody

 Also Known As   

CD45 antibody (biotin)

 Product Synonym Names    Monoclonal CD45; Anti-CD45; t200 glycoprotein; ptprc; Leucocyte common antigen; CD-45; CD 45; CD45; leucocyte common antigen LCA
 Product Gene Name   

anti-CD45 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126200
 3D Structure    ModBase 3D Structure for P08575
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    LT40
 Host    Mouse
 Species Reactivity    Chicken
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.5 mg/ml (lot specific)
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 Biological Significance    Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    Biotin
 Immunogen    CD45 antibody (biotin) was raised in mouse using chicken CD45 as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD45 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD45 antibody

   Mouse monoclonal CD45 antibody (biotin)
 Product Categories/Family for anti-CD45 antibody    Proteases, Inhibitors, & Enzymes; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD45 antibody   

Flow Cytometry (FC/FACS), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for CD45. It may not necessarily be applicable to this product.
 NCBI GI #    44242008
 NCBI GeneID    5788
 NCBI Accession #    AAS46946.1 [Other Products]
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 UniProt Primary Accession #    P08575 [Other Products]
 UniProt Secondary Accession #    Q16614; Q9H0Y6; A8K7W6 [Other Products]
 UniProt Related Accession #    P08575 [Other Products]
 Molecular Weight    130,898 Da
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 NCBI Official Full Name    CD45, partial
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, C
 NCBI Official Symbol    PTPRC [Similar Products]
 NCBI Official Synonym Symbols   
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase C
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase C
 UniProt Synonym Protein Names   
Leukocyte common antigen; L-CA; T200; CD_antigen: CD45
 UniProt Gene Name    PTPRC [Similar Products]
 UniProt Synonym Gene Names    CD45; L-CA [Similar Products]
 UniProt Entry Name    PTPRC_HUMAN
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 NCBI Summary for CD45    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
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 UniProt Comments for CD45    CD45: a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described.

Protein type: EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q31-q32

Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; lipid raft; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding

Biological Process: B cell proliferation; axon guidance; substrate-bound cell migration, cell release from substrate; regulation of cell cycle; protein amino acid dephosphorylation; positive regulation of antigen receptor-mediated signaling pathway; T cell receptor signaling pathway; bone marrow development; stem cell development; B cell receptor signaling pathway; cell surface receptor linked signal transduction; dephosphorylation; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; negative regulation of protein kinase activity; negative regulation of cytokine and chemokine mediated signaling pathway; hemopoietic progenitor cell differentiation; positive regulation of T cell proliferation; immunoglobulin biosynthetic process; defense response to virus; T cell differentiation

Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-positive; Hepatitis C Virus, Susceptibility To
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 Research Articles on CD45    1. Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD45 antibodyDiseases associated with anti-CD45 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >79 publications with CD45 and Inflammation
 Necrosis Antibodies  >41 publications with CD45 and Necrosis
 Lung Diseases Antibodies  >25 publications with CD45 and Lung Diseases
 Fibrosis Antibodies  >24 publications with CD45 and Fibrosis
 Multiple Sclerosis Antibodies  >19 publications with CD45 and Multiple Sclerosis
 Breast Neoplasms Antibodies  >18 publications with CD45 and Breast Neoplasms
 Arthritis, Rheumatoid Antibodies  >16 publications with CD45 and Arthritis, Rheumatoid
 Metaplasia Antibodies  >14 publications with CD45 and Metaplasia
 Retinal Diseases Antibodies  >13 publications with CD45 and Retinal Diseases
 Neoplasms, Experimental Antibodies  >11 publications with CD45 and Neoplasms, Experimental
Organs/Tissues associated with anti-CD45 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >409 publications with CD45 and Blood
 Bone Antibodies  >145 publications with CD45 and Bone
 Bone Marrow Antibodies  >135 publications with CD45 and Bone Marrow
 Vascular Antibodies  >84 publications with CD45 and Vascular
 Liver Antibodies  >50 publications with CD45 and Liver
 Brain Antibodies  >48 publications with CD45 and Brain
 Lung Antibodies  >44 publications with CD45 and Lung
 Muscle Antibodies  >42 publications with CD45 and Muscle
 Spleen Antibodies  >33 publications with CD45 and Spleen
 Embryonic Tissue Antibodies  >33 publications with CD45 and Embryonic Tissue
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