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anti-CD46 antibody :: Mouse CD46 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213724
Unit / Price
100 Tests  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD46, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD46:RPE

 Product Gene Name   

anti-CD46 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120920
 3D Structure    ModBase 3D Structure for P15529
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MEM-258
 Host    Mouse
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
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 Reconstitution    Reconstitute with 1 ml distilled water
Perservative Stabilisers
 Immunogen    HPB-ALL cell line
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-CD46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD46 antibody

   Mouse anti Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP). CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilisation.
 Applications Tested/Suitable for anti-CD46 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD46 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 or 100ul whole blood.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD46 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46:RPE
anti-CD46 antibody Testing Data image
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 Testing Data of anti-CD46 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46 (MBS212502)
anti-CD46 antibody Testing Data image
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 Testing Data of anti-CD46 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human CD46: Alexa Fluor 647 (MBS212502A647)
anti-CD46 antibody Testing Data image
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 Testing Data of anti-CD46 antibody    Staining of human peripheral blood lymphocytes with Mouse anti Human CD46:FITC (MBS210843)
anti-CD46 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD46. It may not necessarily be applicable to this product.
 NCBI GI #    27502402
 NCBI GeneID    4179
 NCBI Accession #    NP_002380.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002389.4 [Other Products]
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 UniProt Primary Accession #    P15529 [Other Products]
 UniProt Secondary Accession #    Q15429; Q53GV9; Q5HY94; Q5VWS6; Q5VWS7; Q5VWS8; Q5VWS9; Q5VWT0; A0T1T0; A0T1T1; A0T1T2 [Other Products]
 UniProt Related Accession #    P15529 [Other Products]
 Molecular Weight    36,826 Da
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 NCBI Official Full Name    membrane cofactor protein isoform 1
 NCBI Official Synonym Full Names    CD46 molecule, complement regulatory protein
 NCBI Official Symbol    CD46 [Similar Products]
 NCBI Official Synonym Symbols   
MCP; TLX; AHUS2; MIC10; TRA2.10
[Similar Products]
 NCBI Protein Information    membrane cofactor protein; CD46 antigen, complement regulatory protein; antigen identified by monoclonal antibody TRA-2-10; complement membrane cofactor protein; measles virus receptor; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); trophoblast leucocyte common antigen; trophoblast leukocyte common antigen
 UniProt Protein Name    Membrane cofactor protein
 UniProt Synonym Protein Names   
TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46
 Protein Family    Membrane cofactor protein
 UniProt Gene Name    CD46 [Similar Products]
 UniProt Synonym Gene Names    MCP; MIC10 [Similar Products]
 UniProt Entry Name    MCP_HUMAN
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 NCBI Summary for CD46    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
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 UniProt Comments for CD46    CD46: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. 16 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: Golgi apparatus; inner acrosomal membrane; focal adhesion; cell surface; integral to plasma membrane; basolateral plasma membrane; plasma membrane

Molecular Function: complement binding; enzyme inhibitor activity; protein binding; cadherin binding; endopeptidase activity; receptor activity

Biological Process: positive regulation of memory T cell differentiation; adaptive immune response; positive regulation of regulatory T cell differentiation; viral reproduction; T cell mediated immunity; proteolysis; positive regulation of interleukin-10 production; regulation of Notch signaling pathway; negative regulation of complement activation; single fertilization; negative regulation of catalytic activity; regulation of complement activation; interleukin-10 production; innate immune response; positive regulation of T cell proliferation; complement activation, classical pathway
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 Research Articles on CD46    1. Transgenic hCD46/HLA-E expression reduced humoral xenoresponses since all were downregulated during ex vivo xenoperfusion of hCD46/HLA-E double transgenic pig forelimbs with human blood.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD46 antibodyDiseases associated with anti-CD46 antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Disease Name  Pubmed Publications
 Measles Antibodies  >369 publications with CD46 and Measles
 Inflammation Antibodies  >101 publications with CD46 and Inflammation
 Atypical Hemolytic Uremic Syndrome Antibodies  >78 publications with CD46 and Atypical Hemolytic Uremic Syndrome
 Necrosis Antibodies  >63 publications with CD46 and Necrosis
 Brain Diseases Antibodies  >35 publications with CD46 and Brain Diseases
 Lung Diseases Antibodies  >33 publications with CD46 and Lung Diseases
 Liver Diseases Antibodies  >29 publications with CD46 and Liver Diseases
 Breast Neoplasms Antibodies  >26 publications with CD46 and Breast Neoplasms
 Liver Neoplasms Antibodies  >23 publications with CD46 and Liver Neoplasms
 Nephritis Antibodies  >23 publications with CD46 and Nephritis
Organs/Tissues associated with anti-CD46 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >510 publications with CD46 and Blood
 Kidney Antibodies  >112 publications with CD46 and Kidney
 Vascular Antibodies  >96 publications with CD46 and Vascular
 Brain Antibodies  >94 publications with CD46 and Brain
 Liver Antibodies  >75 publications with CD46 and Liver
 Lung Antibodies  >73 publications with CD46 and Lung
 Heart Antibodies  >58 publications with CD46 and Heart
 Bone Antibodies  >48 publications with CD46 and Bone
 Skin Antibodies  >42 publications with CD46 and Skin
 Muscle Antibodies  >38 publications with CD46 and Muscle
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