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anti-CD47 antibody :: Mouse CD47 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS235342
Unit / Price
0.1 mg  /  $205 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD47, Monoclonal Antibody

 Also Known As   

MOUSE ANTI RAT CD47

 Product Gene Name   

anti-CD47 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P97829
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    OX-101
 Host    Mouse
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 Specificity    Clone OX-101 recognizes the rat homologue of human CD47, which has been identified as the ligand for the rat signal regulatory protein (SIRP). Rat CD47 is expressed primarily by lymphocytes and macrophages but has also been detected at high levels on brain endothelial cells.Clone OX-101 has been reported to block the interaction of CD47 and SIRP.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Rat thymocytes
Buffer Solution
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD47 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD47 antibody

   Clone OX-101 recognizes the rat homologue of human CD47, which has been identified as the ligand for the rat signal regulatory protein (SIRP). Rat CD47 is expressed primarily by lymphocytes and macrophages but has also been detected at high levels on brain endothelial cells. Clone OX-101 has been reported to block the interaction of CD47 and SIRP.
 Applications Tested/Suitable for anti-CD47 antibody   

Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD47 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/100
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 Testing Data #1 of anti-CD47 antibody    Staining of Rat Spleen cells with Mouse anti Rat CD47:RPE (MBS213705)
anti-CD47 antibody Testing Data #1 image
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 Testing Data #2 of anti-CD47 antibody    Staining of Rat Spleen cells with Mouse anti Rat CD47:Alexa FluorR 647 (MBS212449)
anti-CD47 antibody Testing Data #2 image
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 Testing Data #3 of anti-CD47 antibody    Staining of Rat Spleen cells with Mouse anti Rat CD47:FITC (MBS235335)
anti-CD47 antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for CD47. It may not necessarily be applicable to this product.
 NCBI GI #    9506469
 NCBI GeneID    29364
 NCBI Accession #    NP_062068.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019195.2 [Other Products]
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 UniProt Primary Accession #    P97829 [Other Products]
 UniProt Secondary Accession #    O35294 [Other Products]
 UniProt Related Accession #    P97829 [Other Products]
 Molecular Weight    34,776 Da
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 NCBI Official Full Name    leukocyte surface antigen CD47
 NCBI Official Synonym Full Names    Cd47 molecule
 NCBI Official Symbol    Cd47 [Similar Products]
 NCBI Official Synonym Symbols   
Itgp
[Similar Products]
 NCBI Protein Information    leukocyte surface antigen CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); IAP; integrin-associated protein
 UniProt Protein Name    Leukocyte surface antigen CD47
 UniProt Synonym Protein Names   
Integrin-associated protein; IAP; CD_antigen: CD47
 Protein Family    Leukocyte surface antigen
 UniProt Gene Name    Cd47 [Similar Products]
 UniProt Synonym Gene Names    IAP [Similar Products]
 UniProt Entry Name    CD47_RAT
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 NCBI Summary for CD47    protein that may be involved in regulating renal cell growth; overexpression is associated with Fe-NTA-induced renal damage and tumor progression and metastasis [RGD, Feb 2006]
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 UniProt Comments for CD47    CD47: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Biological Process: integrin-mediated signaling pathway; cell migration; response to bacterium; positive regulation of phagocytosis; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of T cell activation; opsonization; cell adhesion; positive regulation of inflammatory response
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 Research Articles on CD47    1. The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD47 antibodyDiseases associated with anti-CD47 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies  Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >87 publications with CD47 and Immune System Diseases
 Inflammation Antibodies  >83 publications with CD47 and Inflammation
 Disease Models, Animal Antibodies  >48 publications with CD47 and Disease Models, Animal
 Anemia Antibodies  >43 publications with CD47 and Anemia
 Necrosis Antibodies  >43 publications with CD47 and Necrosis
 Nervous System Diseases Antibodies  >34 publications with CD47 and Nervous System Diseases
 Brain Diseases Antibodies  >30 publications with CD47 and Brain Diseases
 Neoplasms, Experimental Antibodies  >23 publications with CD47 and Neoplasms, Experimental
 Respiratory Tract Diseases Antibodies  >14 publications with CD47 and Respiratory Tract Diseases
 Diabetes Mellitus Antibodies  >11 publications with CD47 and Diabetes Mellitus
Organs/Tissues associated with anti-CD47 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >58 publications with CD47 and Brain
 Lung Antibodies  >28 publications with CD47 and Lung
 Liver Antibodies  >28 publications with CD47 and Liver
 Spleen Antibodies  >27 publications with CD47 and Spleen
 Kidney Antibodies  >17 publications with CD47 and Kidney
 Heart Antibodies  >13 publications with CD47 and Heart
 Connective Tissue Antibodies  >12 publications with CD47 and Connective Tissue
 Thymus Antibodies  >11 publications with CD47 and Thymus
 Embryonic Tissue Antibodies  >11 publications with CD47 and Embryonic Tissue
 Ovary Antibodies  >10 publications with CD47 and Ovary
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