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anti-CD49a antibody :: Mouse CD49a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214809
Unit / Price
0.025 mg  /  $155 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD49a, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD49a

 Product Gene Name   

anti-CD49a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192968
 3D Structure    ModBase 3D Structure for P56199
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    TS2/7
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD49a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD49a antibody

   Mouse anti Human CD49a antibody, clone TS2/7 recognizes the human alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin. VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells. Mouse anti Human CD49a antibody, clone TS2/7 has been reported as being suitable for use in Western Blotting. Mouse anti Human CD49a antibody, clone TS2/7 is routinely tested in flow cytometry using HeLa cells.
 Applications Tested/Suitable for anti-CD49a antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD49a antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/25; Maximum Dilution: 1/50
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 Testing Data of anti-CD49a antibody    Staining of HeLa cells with Mouse anti Human CD49a (MBS210309)
anti-CD49a antibody Testing Data image
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 Testing Data of anti-CD49a antibody    Staining of HeLa cells with Mouse anti Human CD49a (MBS212035)
anti-CD49a antibody Testing Data image
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 Testing Data of anti-CD49a antibody    Staining of HeLa cells with Mouse anti Human CD49a: Alexa Fluor 488 (MBS216814A488)
anti-CD49a antibody Testing Data image
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 Testing Data of anti-CD49a antibody    Staining of HeLa cells with Mouse anti Human CD49a:FITC (MBS210620)
anti-CD49a antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD49a. It may not necessarily be applicable to this product.
 NCBI GI #    31657142
 NCBI GeneID    3672
 NCBI Accession #    NP_852478.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_181501.1 [Other Products]
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 UniProt Primary Accession #    P56199 [Other Products]
 UniProt Secondary Accession #    B2RNU0 [Other Products]
 UniProt Related Accession #    P56199 [Other Products]
 Molecular Weight    130,848 Da
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 NCBI Official Full Name    integrin alpha-1
 NCBI Official Synonym Full Names    integrin, alpha 1
 NCBI Official Symbol    ITGA1 [Similar Products]
 NCBI Official Synonym Symbols   
VLA1; CD49a
[Similar Products]
 NCBI Protein Information    integrin alpha-1; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation protein 1
 UniProt Protein Name    Integrin alpha-1
 UniProt Synonym Protein Names   
CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a
 UniProt Gene Name    ITGA1 [Similar Products]
 UniProt Entry Name    ITA1_HUMAN
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 NCBI Summary for CD49a    This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD49a    ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: neuron projection; cell surface; focal adhesion; membrane; plasma membrane; acrosome; perikaryon; integrin complex; lipid raft; external side of plasma membrane

Molecular Function: collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; integrin-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; neutrophil chemotaxis; axon guidance; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation
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 Research Articles on CD49a    1. miR-101:DNMT-3B interaction modulates integrin alpha-1 epigenetically.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD49a antibodyPathways associated with anti-CD49a antibody
 Reference Product  PubMed Publications
 ITGB1 antibody  >2 publications with CD49a and ITGB1
 ITGB2 antibody  >1 publications with CD49a and ITGB2
 ITGB5 antibody  >1 publications with CD49a and ITGB5
 LAMA1 antibody  >1 publications with CD49a and LAMA1
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
Diseases associated with anti-CD49a antibodyOrgans/Tissues associated with anti-CD49a antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with CD49a and Inflammation
 Fibrosis Antibodies  >2 publications with CD49a and Fibrosis
 Necrosis Antibodies  >2 publications with CD49a and Necrosis
 Nervous System Malformations Antibodies  >1 publications with CD49a and Nervous System Malformations
 Breast Neoplasms Antibodies  >1 publications with CD49a and Breast Neoplasms
 Prostatic Diseases Antibodies  >1 publications with CD49a and Prostatic Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CD49a and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with CD49a and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with CD49a and Ovarian Neoplasms
 Cognition Disorders Antibodies  >1 publications with CD49a and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with CD49a and Blood
 Bone Antibodies  >6 publications with CD49a and Bone
 Vascular Antibodies  >4 publications with CD49a and Vascular
 Muscle Antibodies  >4 publications with CD49a and Muscle
 Placenta Antibodies  >3 publications with CD49a and Placenta
 Heart Antibodies  >3 publications with CD49a and Heart
 Brain Antibodies  >3 publications with CD49a and Brain
 Liver Antibodies  >2 publications with CD49a and Liver
 Skin Antibodies  >1 publications with CD49a and Skin
 Adipose Tissue Antibodies  >1 publications with CD49a and Adipose Tissue
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