NP_034706.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
115,696 Da
NCBI Official Full Name
integrin alpha-4
NCBI Official Synonym Full Names
integrin alpha 4
NCBI Protein Information
integrin alpha-4; CD49 antigen-like family member D; LPAM subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha; integrin alpha-IV; integrin alpha4B; lymphocyte Peyer patch adhesion molecules subunit alpha
UniProt Protein Name
Integrin alpha-4
UniProt Synonym Protein Names
CD49 antigen-like family member D; Integrin alpha-IV; Lymphocyte Peyer patch adhesion molecules subunit alpha; LPAM subunit alpha; VLA-4 subunit alpha; CD_antigen: CD49d
UniProt Synonym Gene Names
UniProt Entry Name
ITA4_MOUSE
UniProt Comments for CD49d
ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family.
Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: focal adhesion; cell surface; membrane; integral to membrane; plasma membrane; intercellular junction; integrin complex; external side of plasma membrane
Molecular Function: metal ion binding; fibronectin binding; cell adhesion molecule binding
Biological Process: heterophilic cell adhesion; integrin-mediated signaling pathway; heterotypic cell-cell adhesion; cell-cell adhesion; cell migration; leukocyte adhesion; heart development; cell-matrix adhesion; blood vessel remodeling; cell adhesion; leukocyte tethering or rolling; receptor clustering
Research Articles on CD49d
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Pathways associated with anti-CD49d antibody
Diseases associated with anti-CD49d antibody
Organs/Tissues associated with anti-CD49d antibody
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