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anti-CD49f antibody :: Rat CD49f Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213117
Unit / Price
0.2 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD49f, Monoclonal Antibody

 Also Known As   

RAT ANTI HUMAN CD49f

 Product Gene Name   

anti-CD49f antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147556
 3D Structure    ModBase 3D Structure for P23229
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    NKI-GoH3
 Host    Rat
 Species Reactivity    Cynomolgus monkey, Dog, Mouse, Pig, Sheep
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Histology Positive Control Tissue    Human Tonsil
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD49f antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD49f antibody

   Rat anti Human CD49f antibody, clone NKI-GoH3 recognizes CD49F (VLA-6 alpha chain), a 120kD cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (Sonnenberg et al. 1998).
 Applications Tested/Suitable for anti-CD49f antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD49f antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 platelets in 100ul.
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 Testing Data of anti-CD49f antibody    Staining of human peripheral blood lymphocytes with Rat anti Human CD49f:Biotin (MBS210508)
anti-CD49f antibody Testing Data image
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 Testing Data of anti-CD49f antibody    Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin (MBS210508)
anti-CD49f antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD49f. It may not necessarily be applicable to this product.
 NCBI GI #    119395742
 NCBI GeneID    3655
 NCBI Accession #    NP_000201.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000210.2 [Other Products]
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 UniProt Primary Accession #    P23229 [Other Products]
 UniProt Secondary Accession #    Q08443; Q0MRC7; Q14646; Q16508; Q53RX7; Q59HB7; B2RMU9; B4DG69; B4DKB8; C4AM96; G5E9H1 [Other Products]
 UniProt Related Accession #    P23229 [Other Products]
 Molecular Weight    122,358 Da
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 NCBI Official Full Name    integrin alpha-6 isoform b
 NCBI Official Synonym Full Names    integrin, alpha 6
 NCBI Official Symbol    ITGA6 [Similar Products]
 NCBI Official Synonym Symbols   
CD49f; VLA-6; ITGA6B
[Similar Products]
 NCBI Protein Information    integrin alpha-6; CD49 antigen-like family member F; integrin alpha6B
 UniProt Protein Name    Integrin alpha-6
 UniProt Synonym Protein Names   
CD49 antigen-like family member F; VLA-6; CD_antigen: CD49fCleaved into the following 3 chains:Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6; Alpha6p
 UniProt Gene Name    ITGA6 [Similar Products]
 UniProt Synonym Gene Names    Alpha6p [Similar Products]
 UniProt Entry Name    ITA6_HUMAN
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 NCBI Summary for CD49f    The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD49f    ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: focal adhesion; cell surface; cell-cell adherens junction; hemidesmosome; basal plasma membrane; plasma membrane; basement membrane; external side of plasma membrane; filopodium

Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding

Biological Process: integrin-mediated signaling pathway; skin development; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; hemidesmosome assembly; cell-cell adhesion; gut development; brown fat cell differentiation; cellular response to extracellular stimulus; cell-substrate junction assembly; positive regulation of cell-cell adhesion; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
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 Research Articles on CD49f    1. These data suggest that systemic targeting of the ITGA6-dependent function of established tumors in bone may offer a noncytotoxic approach to arrest the osteolytic progression of metastatic prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to RAT ANTI HUMAN CD49f
 Catalog #  Product Name  Catalog #  Product Name
 MBS666247  anti-human CD49f-Purified (with Antibiotics)  MBS530157  CD49f antibody (FITC)
 MBS820371  Anti-CD49f LC Antibody  MBS213609  MOUSE ANTI HUMAN CD49f:RPE
 MBS243540  Rabbit Polyclonal to Human ITGA6/Integrin Alpha 6/CD49f  MBS247075  Rabbit Polyclonal to Human ITGA6/Integrin Alpha 6/CD49f
 MBS8200365  Anti-CD49f Antibody  MBS215047  MOUSE ANTI HUMAN CD49f:RPE
 MBS670279  Mouse Anti-Human CD49f-PE  MBS833415  CD49f antibody (PE)
Pathways associated with anti-CD49f antibodyDiseases associated with anti-CD49f antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Epidermolysis bullosa with pyloric atresia Antibodies  >11 publications with CD49f and Epidermolysis bullosa with pyloric atresia
 Breast Neoplasms Antibodies  >9 publications with CD49f and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with CD49f and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >5 publications with CD49f and Prostatic Diseases
 Fibrosis Antibodies  >5 publications with CD49f and Fibrosis
 Prostatic Neoplasms Antibodies  >4 publications with CD49f and Prostatic Neoplasms
 Inflammation Antibodies  >4 publications with CD49f and Inflammation
 Neoplasm Invasiveness Antibodies  >4 publications with CD49f and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >3 publications with CD49f and Liver Neoplasms
 Skin Neoplasms Antibodies  >3 publications with CD49f and Skin Neoplasms
Organs/Tissues associated with anti-CD49f antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >21 publications with CD49f and Skin
 Testis Antibodies  >12 publications with CD49f and Testis
 Stomach Antibodies  >10 publications with CD49f and Stomach
 Blood Antibodies  >10 publications with CD49f and Blood
 Prostate Antibodies  >9 publications with CD49f and Prostate
 Bone Antibodies  >7 publications with CD49f and Bone
 Vascular Antibodies  >5 publications with CD49f and Vascular
 Liver Antibodies  >5 publications with CD49f and Liver
 Brain Antibodies  >5 publications with CD49f and Brain
 Mouth Antibodies  >4 publications with CD49f and Mouth
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