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anti-CD5 antibody :: Rat CD5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215753
Unit / Price
0.025 mg  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD5, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD5:FITC

 Product Gene Name   

anti-CD5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P13379
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    YTS 121.5.2
 Host    Rat
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Immunogen    CBA mouse thymocytes.
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD5 antibody

   Rat anti Mouse CD5 antibody, clone YTS 121.5.2 recognizes murine CD5 (Lyt-1) a cell surface glycoprotein expressed by T-lymphocytes.Studies suggest that CD5 plays an important role in the regulation of immune tolerance and lymphocyte selection.Rat anti Mouse CD5 antibody, clone YTS 121.5.2 is suitable for T-cell depletion in vivo (Cobbold et al. 1984).
 Applications Tested/Suitable for anti-CD5 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD5 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD5 antibody    Staining of mouse peripheral blood lymphocytes with Rat anti Mouse CD5:Biotin (MBS210431)
anti-CD5 antibody Testing Data image
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 Testing Data of anti-CD5 antibody    Staining of mouse spleen cells with Rat anti Mouse CD5 (MBS212644)
anti-CD5 antibody Testing Data image
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 Testing Data of anti-CD5 antibody    Staining of mouse spleen cells with Rat anti Mouse CD5: Alexa Fluor 647 (MBS212643A647)
anti-CD5 antibody Testing Data image
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 Testing Data of anti-CD5 antibody    Staining of mouse peripheral blood lymphocytes with Rat anti Mouse CD5 (MBS212643)
anti-CD5 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD5. It may not necessarily be applicable to this product.
 NCBI GI #    126517489
 NCBI GeneID    12507
 NCBI Accession #    NP_031676.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_007650.3 [Other Products]
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 UniProt Primary Accession #    P13379 [Other Products]
 UniProt Related Accession #    P13379 [Other Products]
 Molecular Weight    53,849 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD5
 NCBI Official Synonym Full Names    CD5 antigen
 NCBI Official Symbol    Cd5 [Similar Products]
 NCBI Official Synonym Symbols   
Ly-1; Ly-A; Ly-12; Lyt-1
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD5; lymphocyte antigen 1
 UniProt Protein Name    T-cell surface glycoprotein CD5
 UniProt Synonym Protein Names   
Lymphocyte antigen 1; Ly-1; Lyt-1; CD_antigen: CD5
 Protein Family    CD5 antigen
 UniProt Gene Name    Cd5 [Similar Products]
 UniProt Synonym Gene Names    Ly-1; Ly-1; Lyt-1 [Similar Products]
 UniProt Entry Name    CD5_MOUSE
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 UniProt Comments for CD5    CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; glycoprotein binding; scavenger receptor activity

Biological Process: T cell costimulation
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 Research Articles on CD5    1. Data indicate that CD5-casein kinase 2 (CK2) signaling is necessary for efficient nuclear localization of orphan nuclear receptor ROR-gammaT (RORgammat).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD5 antibodyDiseases associated with anti-CD5 antibody
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >1902 publications with CD5 and Lymphoma
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >992 publications with CD5 and Leukemia, Lymphocytic, Chronic, B-Cell
 Arthritis, Rheumatoid Antibodies  >176 publications with CD5 and Arthritis, Rheumatoid
 Necrosis Antibodies  >170 publications with CD5 and Necrosis
 Inflammation Antibodies  >168 publications with CD5 and Inflammation
 Liver Diseases Antibodies  >132 publications with CD5 and Liver Diseases
 Neoplasms, Experimental Antibodies  >118 publications with CD5 and Neoplasms, Experimental
 Hyperplasia Antibodies  >98 publications with CD5 and Hyperplasia
 Lung Diseases Antibodies  >92 publications with CD5 and Lung Diseases
 Kidney Diseases Antibodies  >81 publications with CD5 and Kidney Diseases
Organs/Tissues associated with anti-CD5 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1074 publications with CD5 and Bone Marrow
 Lymph Node Antibodies  >737 publications with CD5 and Lymph Node
 Spleen Antibodies  >657 publications with CD5 and Spleen
 Thymus Antibodies  >481 publications with CD5 and Thymus
 Embryonic Tissue Antibodies  >80 publications with CD5 and Embryonic Tissue
 Heart Antibodies  >55 publications with CD5 and Heart
 Salivary Gland Antibodies  >36 publications with CD5 and Salivary Gland
 Mammary Gland Antibodies  >8 publications with CD5 and Mammary Gland
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