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anti-CD51/CD61 antibody :: Mouse CD51/CD61 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213148
Testing Data #1
Unit / Price
0.1 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD51/CD61, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD51/CD61

 Product Gene Name   

anti-CD51/CD61 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173470
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    23C6
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Osteoclasts from osteoclastomas
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch
 Other Notes    Small volumes of anti-CD51/CD61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD51/CD61 antibody

   Mouse anti Human CD51/CD61 antibody, clone 23C6 recognizes the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Mouse anti Human CD51/CD61 antibody, clone 23C6 reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
 Applications Tested/Suitable for anti-CD51/CD61 antibody   

Immunohistology Frozen*, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD51/CD61 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Immunohistology - Frozen: Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
Flow Cytometry: Minimum Dilution: 1/40; Maximum Dilution: 1/80
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 Testing Data #1 of anti-CD51/CD61 antibody    Staining of KG1a cell line with Mouse anti Human CD51/CD61:RPE (MBS213878)
anti-CD51/CD61 antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for CD51/CD61. It may not necessarily be applicable to this product.
 NCBI GI #    47078292
 NCBI GeneID    3690
 NCBI Accession #    NP_000203.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000212.2 [Other Products]
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 UniProt Secondary Accession #    O15495; Q12806; Q13413; Q14648; Q16499; A0PJW2; D3DXJ8 [Other Products]
 UniProt Related Accession #    P05106 [Other Products]
 Molecular Weight    86,694 Da
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 NCBI Official Full Name    integrin beta-3
 NCBI Official Synonym Full Names    integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
 NCBI Official Symbol    ITGB3 [Similar Products]
 NCBI Official Synonym Symbols   
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
[Similar Products]
 NCBI Protein Information    integrin beta-3; platelet membrane glycoprotein IIIa
 UniProt Protein Name    Integrin beta-3
 UniProt Synonym Protein Names   
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
 UniProt Gene Name    ITGB3 [Similar Products]
 UniProt Synonym Gene Names    GP3A; GPIIIa [Similar Products]
 UniProt Entry Name    ITB3_HUMAN
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 NCBI Summary for CD51/CD61    The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD51/CD61    ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: filopodium membrane; platelet alpha granule membrane; cell surface; focal adhesion; integral to plasma membrane; microvillus membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex

Molecular Function: identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; protein disulfide isomerase activity; platelet-derived growth factor receptor binding; receptor activity; cell adhesion molecule binding

Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; wound healing; protein folding; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; mesodermal cell differentiation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; tube development; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration

Disease: Myocardial Infarction, Susceptibility To; Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
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 Research Articles on CD51/CD61    1. Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD51/CD61 antibodyPathways associated with anti-CD51/CD61 antibody
 Reference Product  PubMed Publications
 ITGA2B antibody  >56 publications with CD51/CD61 and ITGA2B
 ITGAV antibody  >18 publications with CD51/CD61 and ITGAV
 SRC antibody  >5 publications with CD51/CD61 and SRC
 PTK2 antibody  >5 publications with CD51/CD61 and PTK2
 FN1 antibody  >4 publications with CD51/CD61 and FN1
 SYK antibody  >3 publications with CD51/CD61 and SYK
 KDR antibody  >2 publications with CD51/CD61 and KDR
 VTN antibody  >2 publications with CD51/CD61 and VTN
 ITGA7 antibody  >1 publications with CD51/CD61 and ITGA7
 TLN1 antibody  >1 publications with CD51/CD61 and TLN1
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
Diseases associated with anti-CD51/CD61 antibodyOrgans/Tissues associated with anti-CD51/CD61 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >58 publications with CD51/CD61 and Cardiovascular Diseases
 Thrombasthenia Antibodies  >29 publications with CD51/CD61 and Thrombasthenia
 Thrombocytopenia Antibodies  >27 publications with CD51/CD61 and Thrombocytopenia
 Thrombosis Antibodies  >20 publications with CD51/CD61 and Thrombosis
 Breast Neoplasms Antibodies  >18 publications with CD51/CD61 and Breast Neoplasms
 Myocardial Infarction Antibodies  >18 publications with CD51/CD61 and Myocardial Infarction
 Inflammation Antibodies  >14 publications with CD51/CD61 and Inflammation
 Child Development Disorders, Pervasive Antibodies  >12 publications with CD51/CD61 and Child Development Disorders, Pervasive
 Necrosis Antibodies  >12 publications with CD51/CD61 and Necrosis
 Stroke Antibodies  >12 publications with CD51/CD61 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with CD51/CD61 and Blood
 Vascular Antibodies  >32 publications with CD51/CD61 and Vascular
 Bone Antibodies  >19 publications with CD51/CD61 and Bone
 Lung Antibodies  >14 publications with CD51/CD61 and Lung
 Uterus Antibodies  >12 publications with CD51/CD61 and Uterus
 Placenta Antibodies  >9 publications with CD51/CD61 and Placenta
 Embryonic Tissue Antibodies  >8 publications with CD51/CD61 and Embryonic Tissue
 Muscle Antibodies  >7 publications with CD51/CD61 and Muscle
 Lymph Node Antibodies  >7 publications with CD51/CD61 and Lymph Node
 Kidney Antibodies  >7 publications with CD51/CD61 and Kidney
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