NP_000203.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,694 Da
NCBI Official Full Name
integrin beta-3
NCBI Official Synonym Full Names
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
NCBI Official Synonym Symbols
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16 [Similar Products]
NCBI Protein Information
integrin beta-3; platelet membrane glycoprotein IIIa
UniProt Protein Name
Integrin beta-3
UniProt Synonym Protein Names
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
UniProt Synonym Gene Names
UniProt Entry Name
ITB3_HUMAN
NCBI Summary for CD51/CD61
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniProt Comments for CD51/CD61
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: filopodium membrane; platelet alpha granule membrane; cell surface; focal adhesion; integral to plasma membrane; microvillus membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex
Molecular Function: identical protein binding; protein binding; protease binding; extracellular matrix binding; vascular endothelial growth factor receptor 2 binding; fibronectin binding; protein disulfide isomerase activity; platelet-derived growth factor receptor binding; receptor activity; cell adhesion molecule binding
Biological Process: negative regulation of lipid transport; axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; wound healing; protein folding; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; mesodermal cell differentiation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; tube development; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration
Disease: Myocardial Infarction, Susceptibility To; Glanzmann Thrombasthenia; Bleeding Disorder, Platelet-type, 16
Research Articles on CD51/CD61
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Products associated with anti-CD51/CD61 antibody
Pathways associated with anti-CD51/CD61 antibody
Diseases associated with anti-CD51/CD61 antibody
Organs/Tissues associated with anti-CD51/CD61 antibody
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