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anti-CD51 antibody :: Rat CD51 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214313 anti-CD51 antibody
Unit / Price
100 Tests  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD51, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD51:RPE

 Product Gene Name   

anti-CD51 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P43406
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    RMV-7
 Host    Rat
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
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 Reconstitution    Reconstitute with 1ml distilled water
Perservative Stabilisers
 Immunogen    cultured LAK cells from Balb/c mice.
Fusion Partners
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-CD51 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD51 antibody

   Rat anti Mouse CD51 antibody, clone RMV-7 recognizes murine CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity (Takahashi et al. 1990).
 Applications Tested/Suitable for anti-CD51 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD51 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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NCBI/Uniprot data below describe general gene information for CD51. It may not necessarily be applicable to this product.
 NCBI GI #    154240716
 NCBI GeneID    16410
 NCBI Accession #    NP_032428.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008402.3 [Other Products]
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 UniProt Primary Accession #    P43406 [Other Products]
 UniProt Secondary Accession #    A2AKI6 [Other Products]
 UniProt Related Accession #    P43406 [Other Products]
 Molecular Weight    115,360 Da
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 NCBI Official Full Name    integrin alpha-V
 NCBI Official Synonym Full Names    integrin alpha V
 NCBI Official Symbol    Itgav [Similar Products]
 NCBI Official Synonym Symbols   
CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
[Similar Products]
 NCBI Protein Information    integrin alpha-V; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha
 UniProt Protein Name    Integrin alpha-V
 UniProt Synonym Protein Names   
Vitronectin receptor subunit alpha; CD_antigen: CD51Cleaved into the following 2 chains:Integrin alpha-V heavy chain; Integrin alpha-V light chain
 UniProt Gene Name    Itgav [Similar Products]
 UniProt Entry Name    ITAV_MOUSE
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 NCBI Summary for CD51    This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
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 UniProt Comments for CD51    ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Cellular Component: filopodium membrane; cell surface; focal adhesion; membrane; microvillus membrane; integral to membrane; plasma membrane; intracellular; cytosol; nucleus; integrin complex; external side of plasma membrane

Molecular Function: voltage-gated calcium channel activity; opsonin binding; insulin-like growth factor I binding; protease binding; protein kinase C binding; extracellular matrix binding; protein heterodimerization activity; fibronectin binding; metal ion binding; peptide binding; receptor binding

Biological Process: focal adhesion formation; negative regulation of lipid transport; entry of virus into host cell; positive regulation of cell adhesion; T cell activation; multicellular organismal development; cell-matrix adhesion; negative chemotaxis; gonad morphogenesis; regulation of phagocytosis; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; angiogenesis; inflammatory response; cell adhesion; cell differentiation; cell growth; integrin-mediated signaling pathway; blood vessel development; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; detection of molecule of bacterial origin; cell-substrate adhesion; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; fertilization; negative regulation of low-density lipoprotein receptor biosynthetic process; release of sequestered calcium ion into cytosol; positive regulation of osteoblast proliferation; endothelial cell migration; apoptotic cell clearance; positive regulation of cell migration
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 Research Articles on CD51    1. The integrin alpha5beta1-mediated extracellular matrix signal through the RGD sequence is involved in embryonic enchondral ossification.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD51 antibodyDiseases associated with anti-CD51 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with CD51 and Adenocarcinoma
 Inflammation Antibodies  >5 publications with CD51 and Inflammation
 Liver Diseases Antibodies  >4 publications with CD51 and Liver Diseases
 Neoplasm Metastasis Antibodies  >4 publications with CD51 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >3 publications with CD51 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >3 publications with CD51 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >3 publications with CD51 and Lung Diseases
 Liver Neoplasms Antibodies  >3 publications with CD51 and Liver Neoplasms
 Necrosis Antibodies  >3 publications with CD51 and Necrosis
 Breast Neoplasms Antibodies  >2 publications with CD51 and Breast Neoplasms
Organs/Tissues associated with anti-CD51 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with CD51 and Bone
 Blood Antibodies  >8 publications with CD51 and Blood
 Liver Antibodies  >5 publications with CD51 and Liver
 Lung Antibodies  >4 publications with CD51 and Lung
 Lymph Node Antibodies  >4 publications with CD51 and Lymph Node
 Uterus Antibodies  >3 publications with CD51 and Uterus
 Bone Marrow Antibodies  >3 publications with CD51 and Bone Marrow
 Prostate Antibodies  >2 publications with CD51 and Prostate
 Skin Antibodies  >2 publications with CD51 and Skin
 Kidney Antibodies  >2 publications with CD51 and Kidney
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