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anti-CD55 antibody :: Mouse CD55 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS217346
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD55, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD55

 Product Gene Name   

anti-CD55 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125240
 3D Structure    ModBase 3D Structure for P08174
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Bu14
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD55 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD55 antibody

   Mouse anti Human CD55 antibody, clone Bu14 recognizes human CD55, also known as Decay Accelerating Factor (DAF). CD55 is a glycosylphosphatylinositol (GPI) anchored type I surface protein which prevents complement mediated lysis of autologous cells. CD55 functions to limit the formation and accelerate the decay of C3/C5-convertases from the classic and alternative pathway. The molecular weight of CD55 varies between 50 and 100kDa dependent on cell type. Alternative transcripts can lead to soluble DAF, which is detectable in plasma, tears, saliva, urine and cerebrospinal fluid. CD55 is the receptor for CD97, Echovirus and Coxsackie B virus, and has been linked to many diseases including multiple sclerosis, rheumatoid arthritis and cancer development.
 Applications Tested/Suitable for anti-CD55 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD55 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/200
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 Testing Data of anti-CD55 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD55:FITC (MBS217347)
anti-CD55 antibody Testing Data image
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 Testing Data of anti-CD55 antibody    Staining of human peripheral blood monocytes with Mouse anti Human CD55
anti-CD55 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD55. It may not necessarily be applicable to this product.
 NCBI GI #    10835143
 NCBI GeneID    1604
 NCBI Accession #    NP_000565.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000574.4 [Other Products]
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 UniProt Primary Accession #    P08174 [Other Products]
 UniProt Secondary Accession #    P09679; P78361; Q14UF2; Q14UF3; Q14UF4; Q14UF5; Q14UF6; B1AP14; D3DT83; D3DT84; E7ER69 [Other Products]
 UniProt Related Accession #    P08174 [Other Products]
 Molecular Weight    59,038 Da
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 NCBI Official Full Name    complement decay-accelerating factor isoform 1 preproprotein
 NCBI Official Synonym Full Names    CD55 molecule, decay accelerating factor for complement (Cromer blood group)
 NCBI Official Symbol    CD55 [Similar Products]
 NCBI Official Synonym Symbols   
CR; TC; DAF; CROM
[Similar Products]
 NCBI Protein Information    complement decay-accelerating factor; CD55 antigen
 UniProt Protein Name    Complement decay-accelerating factor
 UniProt Synonym Protein Names   
CD_antigen: CD55
 Protein Family    Complement decay-accelerating factor
 UniProt Gene Name    CD55 [Similar Products]
 UniProt Synonym Gene Names    CR; DAF [Similar Products]
 UniProt Entry Name    DAF_HUMAN
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 NCBI Summary for CD55    This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CD55    CD55: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Belongs to the receptors of complement activation (RCA) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; extracellular region; lipid raft

Molecular Function: viral receptor activity; protein binding; lipid binding

Biological Process: respiratory burst; elevation of cytosolic calcium ion concentration; entry of virus into host cell; negative regulation of complement activation; regulation of complement activation; innate immune response; regulation of lipopolysaccharide-mediated signaling pathway; complement activation, classical pathway

Disease: Blood Group, Cromer System
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 Research Articles on CD55    1. The presence of CD55- and/or CD59-deficient erythrocytic populations in patients with rheumatic diseases reflects an immune-mediated bone-marrow derived phenomenon.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD55 antibodyPathways associated with anti-CD55 antibody
 Reference Product  PubMed Publications
 CD59 antibody  >825 publications with CD55 and CD59
 CD97 antibody  >50 publications with CD55 and CD97
 ICAM1 antibody  >30 publications with CD55 and ICAM1
 PIGA antibody  >13 publications with CD55 and PIGA
 EMR2 antibody  >10 publications with CD55 and EMR2
 FYN antibody  >5 publications with CD55 and FYN
 VEGFA antibody  >3 publications with CD55 and VEGFA
 CD1D antibody  >3 publications with CD55 and CD1D
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD55 antibodyOrgans/Tissues associated with anti-CD55 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >337 publications with CD55 and Anemia
 Inflammation Antibodies  >142 publications with CD55 and Inflammation
 Carcinoma Antibodies  >85 publications with CD55 and Carcinoma
 Necrosis Antibodies  >81 publications with CD55 and Necrosis
 Disease Models, Animal Antibodies  >63 publications with CD55 and Disease Models, Animal
 Kidney Diseases Antibodies  >55 publications with CD55 and Kidney Diseases
 Nervous System Diseases Antibodies  >50 publications with CD55 and Nervous System Diseases
 Lung Diseases Antibodies  >31 publications with CD55 and Lung Diseases
 Breast Neoplasms Antibodies  >24 publications with CD55 and Breast Neoplasms
 Heart Diseases Antibodies  >23 publications with CD55 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >907 publications with CD55 and Blood
 Vascular Antibodies  >206 publications with CD55 and Vascular
 Kidney Antibodies  >148 publications with CD55 and Kidney
 Bone Antibodies  >127 publications with CD55 and Bone
 Heart Antibodies  >126 publications with CD55 and Heart
 Bone Marrow Antibodies  >116 publications with CD55 and Bone Marrow
 Muscle Antibodies  >86 publications with CD55 and Muscle
 Lung Antibodies  >85 publications with CD55 and Lung
 Liver Antibodies  >81 publications with CD55 and Liver
 Ovary Antibodies  >49 publications with CD55 and Ovary
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