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anti-NCAM1 antibody :: Mouse anti-Human CD56 / NCAM1 / NKH1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439343
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD56 / NCAM1 / NKH1, Monoclonal Antibody

★Popular Item★
 Also Known As   

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule
 Product Gene Name   

anti-NCAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116930
 3D Structure    ModBase 3D Structure for P13591
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    NCAM1/784
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface
 Immunogen    Recombinant human NCAM1 protein
 Hu-Chromosome Location    11q23.1
 Positive Control    Cerebellum, Pancreas, Neuroblastoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-NCAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NCAM1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-NCAM1 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-NCAM1 antibody    Formalin-fixed, paraffin-embedded human Colon stained with CD56 Monoclonal Antibody (NCAM1/784)
anti-NCAM1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NCAM1. It may not necessarily be applicable to this product.
 NCBI GI #    94420689
 NCBI GeneID    4684
 NCBI Accession #    NP_000606.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000615.6 [Other Products]
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 UniProt Primary Accession #    P13591 [Other Products]
 UniProt Secondary Accession #    P13592; P13593; Q05C58; Q15829; Q16180; Q16209; Q59FL7; Q86X47; Q96CJ3; A8K8T8 [Other Products]
 UniProt Related Accession #    P13591 [Other Products]
 Molecular Weight    180; 145; 125kDa
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 NCBI Official Full Name    neural cell adhesion molecule 1 isoform 1
 NCBI Official Synonym Full Names    neural cell adhesion molecule 1
 NCBI Official Symbol    NCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD56; NCAM; MSK39
[Similar Products]
 NCBI Protein Information    neural cell adhesion molecule 1
 UniProt Protein Name    Neural cell adhesion molecule 1
 UniProt Synonym Protein Names   
CD_antigen: CD56
 Protein Family    Neural cell adhesion molecule
 UniProt Gene Name    NCAM1 [Similar Products]
 UniProt Synonym Gene Names    NCAM; N-CAM-1; NCAM-1 [Similar Products]
 UniProt Entry Name    NCAM1_HUMAN
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 NCBI Summary for NCAM1    This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
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 UniProt Comments for NCAM1    NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cell surface; cytoplasm; external side of plasma membrane; Golgi membrane; membrane; plasma membrane

Molecular Function: Ras guanyl-nucleotide exchange factor activity

Biological Process: axon guidance; MAPKKK cascade
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Product References and Citations for anti-NCAM1 antibody

   Endo, C., et al. 2009. Immunocytochemical evaluation of large cell neuroendocrine carcinoma of the lung. Acta Cytol. 53: 36-40
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 Research Articles on NCAM1    1. CD56 marker is a useful alternative that is comparable to SSTR2A for the diagnosis of phosphaturic mesenchymal tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NCAM1 antibodyPathways associated with anti-NCAM1 antibody
 Reference Product  PubMed Publications
 ICAM1 antibody  >130 publications with NCAM1 and ICAM1
 ST8SIA2 antibody  >80 publications with NCAM1 and ST8SIA2
 FYN antibody  >51 publications with NCAM1 and FYN
 PTK2 antibody  >24 publications with NCAM1 and PTK2
 ST8SIA4 antibody  >20 publications with NCAM1 and ST8SIA4
 IL2 antibody  >18 publications with NCAM1 and IL2
 SPTBN2 antibody  >1 publications with NCAM1 and SPTBN2
 SPTBN1 antibody  >1 publications with NCAM1 and SPTBN1
 PRNP antibody  >1 publications with NCAM1 and PRNP
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-NCAM1 antibodyOrgans/Tissues associated with anti-NCAM1 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >586 publications with NCAM1 and Brain Diseases
 Disease Models, Animal Antibodies  >283 publications with NCAM1 and Disease Models, Animal
 Necrosis Antibodies  >283 publications with NCAM1 and Necrosis
 Inflammation Antibodies  >260 publications with NCAM1 and Inflammation
 Lung Neoplasms Antibodies  >233 publications with NCAM1 and Lung Neoplasms
 Congenital Abnormalities Antibodies  >205 publications with NCAM1 and Congenital Abnormalities
 Liver Diseases Antibodies  >194 publications with NCAM1 and Liver Diseases
 Neoplasm Invasiveness Antibodies  >153 publications with NCAM1 and Neoplasm Invasiveness
 Neurobehavioral Manifestations Antibodies  >120 publications with NCAM1 and Neurobehavioral Manifestations
 Liver Neoplasms Antibodies  >119 publications with NCAM1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2875 publications with NCAM1 and Brain
 Blood Antibodies  >2624 publications with NCAM1 and Blood
 Nerve Antibodies  >1822 publications with NCAM1 and Nerve
 Embryonic Tissue Antibodies  >857 publications with NCAM1 and Embryonic Tissue
 Muscle Antibodies  >584 publications with NCAM1 and Muscle
 Bone Antibodies  >550 publications with NCAM1 and Bone
 Skin Antibodies  >392 publications with NCAM1 and Skin
 Vascular Antibodies  >384 publications with NCAM1 and Vascular
 Eye Antibodies  >349 publications with NCAM1 and Eye
 Lung Antibodies  >343 publications with NCAM1 and Lung
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