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anti-CD59 antibody :: Mouse CD59 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497893
Unit / Price
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD59, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-CD59 monoclonal Antibody

 Product Synonym Names    CD59 glycoprotein; HRF-20; MAC-IP; MACIF; MIRL; CD59
 Product Gene Name   

anti-CD59 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107271
 3D Structure    ModBase 3D Structure for P13987
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human. Other species are not tested. Please decide the specificity by homology
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 Specificity    Specific for Recombinant CD59 Protein denatured and native forms
 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant CD59 Protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133170 / sc-133171 / sc-59095
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CD59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD59 antibody

   CD59, also named as MIC11, MIN1, MIN2, MIN3, MSK21, MIRL, MACIF, HRF20 and 1F5 antigen, is a cell surface molecule glycoprotein with MW 18-25kd. It acts as a determinant of proximal-distal cell identity. CD59 acts by binding to the C8 and/or C9 complements of the assembling membrane attack complex (MAC), thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. It is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
 Applications Tested/Suitable for anti-CD59 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-CD59 antibody    Immunohistochemical of paraffin-embedded Human breast cancer using MBS1497893 (2E11-2B5) at dilution of 1:200.
anti-CD59 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CD59 antibody    Immunohistochemical of paraffin-embedded human placenta tissue using MBS1497893 (2E11-2B5) at dilution of 1:200.
anti-CD59 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CD59 antibody    All lanes: Mouse Anti-CD59 monoclonal antibody at 1ug/ml
Lane 1:K562
Predicted band size: 15kd
Observed band size: 22kd
anti-CD59 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.
 NCBI GI #    10835165
 NCBI GeneID    966
 NCBI Accession #    NP_000602.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000611.5 [Other Products]
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 UniProt Primary Accession #    P13987 [Other Products]
 UniProt Related Accession #    P13987 [Other Products]
 Molecular Weight    14,177 Da
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 NCBI Official Full Name    CD59 glycoprotein preproprotein
 NCBI Official Synonym Full Names    CD59 molecule
 NCBI Official Symbol    CD59 [Similar Products]
 NCBI Official Synonym Symbols   
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
[Similar Products]
 NCBI Protein Information    CD59 glycoprotein
 UniProt Protein Name    CD59 glycoprotein
 UniProt Synonym Protein Names   
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
 Protein Family    CD59 glycoprotein
 UniProt Gene Name    CD59 [Similar Products]
 UniProt Synonym Gene Names    MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL [Similar Products]
 UniProt Entry Name    CD59_HUMAN
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 NCBI Summary for CD59    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD59    CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; cell surface; compact myelin; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; sarcolemma; vesicle

Molecular Function: complement binding; protein binding

Biological Process: blood coagulation; cell surface receptor linked signal transduction; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; innate immune response; negative regulation of activation of membrane attack complex; negative regulation of apoptosis; positive regulation of T cell proliferation; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; regulation of complement activation

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
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 Research Articles on CD59    1. Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen in T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD59 antibodyPathways associated with anti-CD59 antibody
 Reference Product  PubMed Publications
 CD55 antibody  >859 publications with CD59 and CD55
 CD46 antibody  >328 publications with CD59 and CD46
 CD2 antibody  >39 publications with CD59 and CD2
 C8A antibody  >1 publications with CD59 and C8A
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPI-mediated Anterograde Transport Pathway antibodies  COPI-mediated Anterograde Transport Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CD59 antibodyOrgans/Tissues associated with anti-CD59 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >425 publications with CD59 and Anemia
 Inflammation Antibodies  >163 publications with CD59 and Inflammation
 Necrosis Antibodies  >84 publications with CD59 and Necrosis
 Disease Models, Animal Antibodies  >79 publications with CD59 and Disease Models, Animal
 Kidney Diseases Antibodies  >59 publications with CD59 and Kidney Diseases
 Brain Diseases Antibodies  >39 publications with CD59 and Brain Diseases
 Adenocarcinoma Antibodies  >37 publications with CD59 and Adenocarcinoma
 CD59 Deficiency Antibodies  >35 publications with CD59 and CD59 Deficiency
 Lung Diseases Antibodies  >34 publications with CD59 and Lung Diseases
 Proteinuria Antibodies  >30 publications with CD59 and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >989 publications with CD59 and Blood
 Vascular Antibodies  >212 publications with CD59 and Vascular
 Bone Antibodies  >196 publications with CD59 and Bone
 Bone Marrow Antibodies  >188 publications with CD59 and Bone Marrow
 Kidney Antibodies  >125 publications with CD59 and Kidney
 Heart Antibodies  >95 publications with CD59 and Heart
 Muscle Antibodies  >81 publications with CD59 and Muscle
 Liver Antibodies  >77 publications with CD59 and Liver
 Lung Antibodies  >73 publications with CD59 and Lung
 Brain Antibodies  >69 publications with CD59 and Brain
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