NP_037057.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
13,790 Da
NCBI Official Full Name
CD59 glycoprotein
NCBI Official Synonym Full Names
CD59 molecule, complement regulatory protein
NCBI Official Synonym Symbols
Cd59a; Cd59b; MACIF; MACIP; MAC-IP [Similar Products]
NCBI Protein Information
CD59 glycoprotein; CD59 antigen; CD59b moleucle, complement regulatory protein; Cb59b molecule; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin
UniProt Protein Name
CD59 glycoprotein
UniProt Synonym Protein Names
MAC-inhibitory protein; MAC-IP; Membrane attack complex inhibition factor; MACIF; Protectin; CD_antigen: CD59
UniProt Synonym Gene Names
UniProt Entry Name
CD59_RAT
NCBI Summary for CD59
may play a role in regulation of complement; may bind complement proteins C8 and C9 [RGD, Feb 2006]
UniProt Comments for CD59
CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
Protein type: Membrane protein, GPI anchor
Cellular Component: anchored to external side of plasma membrane; extracellular space; compact myelin; cell surface; focal adhesion; plasma membrane; sarcolemma; vesicle
Molecular Function: complement binding
Biological Process: negative regulation of cytolysis; cell surface receptor linked signal transduction; negative regulation of complement activation; regulation of complement activation; negative regulation of activation of membrane attack complex; positive regulation of T cell proliferation; negative regulation of apoptosis
Research Articles on CD59
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Products associated with anti-CD59 antibody
Pathways associated with anti-CD59 antibody
Diseases associated with anti-CD59 antibody
Organs/Tissues associated with anti-CD59 antibody
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