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anti-CD61 antibody :: Mouse CD61 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214397
Testing Data
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD61, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD61

 Product Gene Name   

anti-CD61 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173470
 3D Structure    ModBase 3D Structure for P05106
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Y2/51
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    PHA stimulated peripheral blood cells.
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD61 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD61 antibody

   Mouse anti Human CD61 antibody, clone Y2/51 recognizes CD61, a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin.
 Applications Tested/Suitable for anti-CD61 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-CD61 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200
Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin prior to staining.
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 Testing Data of anti-CD61 antibody    Peripheral Human Monocytes stained with Mouse anti Human CD61:RPE (MBS216266)
anti-CD61 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD61. It may not necessarily be applicable to this product.
 NCBI GI #    47078292
 NCBI GeneID    3690
 NCBI Accession #    NP_000203.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000212.2 [Other Products]
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 UniProt Primary Accession #    P05106 [Other Products]
 UniProt Secondary Accession #    O15495; Q12806; Q13413; Q14648; Q16499; A0PJW2; D3DXJ8 [Other Products]
 UniProt Related Accession #    P05106 [Other Products]
 Molecular Weight    86,694 Da
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 NCBI Official Full Name    integrin beta-3
 NCBI Official Synonym Full Names    integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
 NCBI Official Symbol    ITGB3 [Similar Products]
 NCBI Official Synonym Symbols   
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
[Similar Products]
 NCBI Protein Information    integrin beta-3; platelet membrane glycoprotein IIIa
 UniProt Protein Name    Integrin beta-3
 UniProt Synonym Protein Names   
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
 UniProt Gene Name    ITGB3 [Similar Products]
 UniProt Synonym Gene Names    GP3A; GPIIIa [Similar Products]
 UniProt Entry Name    ITB3_HUMAN
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 NCBI Summary for CD61    The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD61    ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: filopodium membrane; platelet alpha granule membrane; focal adhesion; cell surface; integral to plasma membrane; microvillus membrane; melanosome; plasma membrane; integrin complex; nucleus; receptor complex

Molecular Function: identical protein binding; protein binding; protease binding; vascular endothelial growth factor receptor 2 binding; extracellular matrix binding; fibronectin binding; protein disulfide isomerase activity; platelet-derived growth factor receptor binding; cell adhesion molecule binding; receptor activity

Biological Process: negative regulation of lipid transport; axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; protein folding; wound healing; cell-matrix adhesion; smooth muscle cell migration; negative chemotaxis; mesodermal cell differentiation; positive regulation of vascular endothelial growth factor receptor signaling pathway; platelet degranulation; cell-substrate junction assembly; cell growth; cell adhesion; integrin-mediated signaling pathway; platelet activation; cell migration; regulation of bone resorption; negative regulation of lipoprotein metabolic process; angiogenesis involved in wound healing; cell-substrate adhesion; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; blood coagulation; tube development; vascular endothelial growth factor receptor signaling pathway; leukocyte migration

Disease: Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To; Bleeding Disorder, Platelet-type, 16
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 Research Articles on CD61    1. Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD61 antibodyPathways associated with anti-CD61 antibody
 Reference Product  PubMed Publications
 ITGA2B antibody  >56 publications with CD61 and ITGA2B
 ITGAV antibody  >18 publications with CD61 and ITGAV
 SRC antibody  >5 publications with CD61 and SRC
 PTK2 antibody  >5 publications with CD61 and PTK2
 FN1 antibody  >4 publications with CD61 and FN1
 SYK antibody  >3 publications with CD61 and SYK
 KDR antibody  >2 publications with CD61 and KDR
 VTN antibody  >2 publications with CD61 and VTN
 ITGA7 antibody  >1 publications with CD61 and ITGA7
 TLN1 antibody  >1 publications with CD61 and TLN1
 Products by Pathway  Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
Diseases associated with anti-CD61 antibodyOrgans/Tissues associated with anti-CD61 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >58 publications with CD61 and Cardiovascular Diseases
 Thrombasthenia Antibodies  >29 publications with CD61 and Thrombasthenia
 Thrombocytopenia Antibodies  >27 publications with CD61 and Thrombocytopenia
 Thrombosis Antibodies  >20 publications with CD61 and Thrombosis
 Breast Neoplasms Antibodies  >18 publications with CD61 and Breast Neoplasms
 Myocardial Infarction Antibodies  >18 publications with CD61 and Myocardial Infarction
 Inflammation Antibodies  >14 publications with CD61 and Inflammation
 Child Development Disorders, Pervasive Antibodies  >12 publications with CD61 and Child Development Disorders, Pervasive
 Necrosis Antibodies  >12 publications with CD61 and Necrosis
 Stroke Antibodies  >12 publications with CD61 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with CD61 and Blood
 Vascular Antibodies  >32 publications with CD61 and Vascular
 Bone Antibodies  >19 publications with CD61 and Bone
 Lung Antibodies  >14 publications with CD61 and Lung
 Uterus Antibodies  >12 publications with CD61 and Uterus
 Placenta Antibodies  >9 publications with CD61 and Placenta
 Embryonic Tissue Antibodies  >8 publications with CD61 and Embryonic Tissue
 Muscle Antibodies  >7 publications with CD61 and Muscle
 Lymph Node Antibodies  >7 publications with CD61 and Lymph Node
 Kidney Antibodies  >7 publications with CD61 and Kidney
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