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anti-CD62L antibody :: Mouse CD62L Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214774
Testing Data
Unit / Price
0.025 mg  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD62L, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD62L:FITC

 Product Gene Name   

anti-CD62L antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153240
 3D Structure    ModBase 3D Structure for P14151
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    FMC46
 Host    Mouse
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid.
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
Preparation
 Immunogen    PHA stimulated lymphoblasts.
Fusion Partners
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD62L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD62L antibody

   Mouse anti Human CD62L antibody, clone FMC46 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naŻve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
 Applications Tested/Suitable for anti-CD62L antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD62L antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood.
Flow Cytometry: Maximum Dilution: Neat
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 Testing Data of anti-CD62L antibody    Staining of human peripheral blood granulocytes with Mouse anti Human CD62L:FITC (MBS210612)
anti-CD62L antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD62L. It may not necessarily be applicable to this product.
 NCBI GI #    262206315
 NCBI GeneID    6402
 NCBI Accession #    NP_000646.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000655.4 [Other Products]
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 UniProt Primary Accession #    P14151 [Other Products]
 UniProt Secondary Accession #    P15023; Q9UJ43; B2R6Q8 [Other Products]
 UniProt Related Accession #    P14151 [Other Products]
 Molecular Weight    43,618 Da
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 NCBI Official Full Name    L-selectin
 NCBI Official Synonym Full Names    selectin L
 NCBI Official Symbol    SELL [Similar Products]
 NCBI Official Synonym Symbols   
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
[Similar Products]
 NCBI Protein Information    L-selectin; CD62 antigen-like family member L; gp90-MEL; leukocyte surface antigen Leu-8; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor
 UniProt Protein Name    L-selectin
 UniProt Synonym Protein Names   
CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L
 UniProt Gene Name    SELL [Similar Products]
 UniProt Synonym Gene Names    LNHR; LYAM1; LAM-1; LECAM1 [Similar Products]
 UniProt Entry Name    LYAM1_HUMAN
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 NCBI Summary for CD62L    This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for CD62L    SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23-q25

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: heparin binding; protein binding; protease binding; cell adhesion molecule binding; carbohydrate binding; glycosphingolipid binding

Biological Process: regulation of immune response; cell adhesion; blood coagulation; leukocyte migration; response to ATP

Disease: Iga Nephropathy, Susceptibility To, 1
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 Research Articles on CD62L    1. Increased expression of L-selectin ligands may be involved in the implantation process in tubal pregnancy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD62L antibodyPathways associated with anti-CD62L antibody
 Reference Product  PubMed Publications
 CD44 antibody  >4 publications with CD62L and CD44
 CD34 antibody  >4 publications with CD62L and CD34
 MSN antibody  >2 publications with CD62L and MSN
 SELPLG antibody  >1 publications with CD62L and SELPLG
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Diseases associated with anti-CD62L antibodyOrgans/Tissues associated with anti-CD62L antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >210 publications with CD62L and Nervous System Diseases
 Liver Diseases Antibodies  >117 publications with CD62L and Liver Diseases
 Inflammation Antibodies  >84 publications with CD62L and Inflammation
 Pain Antibodies  >72 publications with CD62L and Pain
 Heart Diseases Antibodies  >70 publications with CD62L and Heart Diseases
 Gastrointestinal Diseases Antibodies  >61 publications with CD62L and Gastrointestinal Diseases
 Carcinoma, Hepatocellular Antibodies  >48 publications with CD62L and Carcinoma, Hepatocellular
 Necrosis Antibodies  >46 publications with CD62L and Necrosis
 Kidney Diseases Antibodies  >35 publications with CD62L and Kidney Diseases
 Fever Antibodies  >29 publications with CD62L and Fever
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >590 publications with CD62L and Blood
 Liver Antibodies  >189 publications with CD62L and Liver
 Bone Antibodies  >175 publications with CD62L and Bone
 Muscle Antibodies  >145 publications with CD62L and Muscle
 Heart Antibodies  >116 publications with CD62L and Heart
 Kidney Antibodies  >98 publications with CD62L and Kidney
 Vascular Antibodies  >92 publications with CD62L and Vascular
 Brain Antibodies  >90 publications with CD62L and Brain
 Lung Antibodies  >81 publications with CD62L and Lung
 Spleen Antibodies  >73 publications with CD62L and Spleen
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