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anti-CD63 antibody :: Mouse anti-Human CD63 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS335647
Testing Data
Unit / Price
0.2 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD63, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human CD63 Monoclonal Antibody, Azide Free Clone TS63

 Product Gene Name   

anti-CD63 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (56119227..56123457, complement). Location: 12q12-q13
 OMIM    155740
 3D Structure    ModBase 3D Structure for P08962
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    TS63
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognises the LIMP antigen, a 30-60 kDa (smear) protein
 Purity/Purification    Ion exchange chromatography
 Form/Format    Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
 Concentration    200ug / 200ul (lot specific)
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 Antigen    CD63
 Hybridoma    Myeloma X63/AG8. x Balb/c spleen cells
 Immunization    Jurkat and HEL cell lines
 Conjugate    Azide free
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 Preparation and Storage    Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots
 Other Notes    Small volumes of anti-CD63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD63 antibody   

Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB)

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 Testing Data of anti-CD63 antibody    1,3 105 HEL cells were lysed (lysis buffer containing 1% Brij97 or triton) Migration SDS/page 5-15% gel under non-reducing conditions
anti-CD63 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD63. It may not necessarily be applicable to this product.
 NCBI GI #    383872547
 NCBI GeneID    967
 NCBI Accession #    NP_001244330.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001257401.1 [Other Products]
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 UniProt Primary Accession #    P08962 [Other Products]
 UniProt Secondary Accession #    Q5TZP3; Q8N6Z9; Q9UCG6; F8VZE2 [Other Products]
 UniProt Related Accession #    P08962 [Other Products]
 Molecular Weight    25,637 Da
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 NCBI Official Full Name    CD63 antigen isoform D
 NCBI Official Synonym Full Names    CD63 molecule
 NCBI Official Symbol    CD63 [Similar Products]
 NCBI Official Synonym Symbols   
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
[Similar Products]
 NCBI Protein Information    CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3
 UniProt Protein Name    CD63 antigen
 UniProt Synonym Protein Names   
Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30
 Protein Family    CD63 antigen
 UniProt Gene Name    CD63 [Similar Products]
 UniProt Synonym Gene Names    MLA1; TSPAN30; LAMP-3; Tspan-30 [Similar Products]
 UniProt Entry Name    CD63_HUMAN
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 NCBI Summary for CD63    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
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 UniProt Comments for CD63    Function: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.

Subcellular location: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note: Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Ref.3 Ref.13 Ref.15 Ref.17 Ref.18

Tissue specificity: Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

Miscellaneous: Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Sequence similarities: Belongs to the tetraspanin (TM4SF) family.
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Product References and Citations for anti-CD63 antibody

   • Charrin et.al Eur J Immunol 2003
• Charrin et.al FEBS lett 2002
• Charrin et.al. J Biol Chem 2001
• Sordat et.al Lab Invest 2002
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 Research Articles on CD63    1. Antigen-induced p38 MAPK phosphorylation in human basophils essentially contributes to CD63 upregulation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD63 antibodyPathways associated with anti-CD63 antibody
 Reference Product  PubMed Publications
 CXCR4 antibody  >12 publications with CD63 and CXCR4
 LAMP2 antibody  >9 publications with CD63 and LAMP2
 TIMP1 antibody  >5 publications with CD63 and TIMP1
 UBC antibody  >3 publications with CD63 and UBC
 NPY antibody  >2 publications with CD63 and NPY
 SELP antibody  >2 publications with CD63 and SELP
 SYT7 antibody  >1 publications with CD63 and SYT7
 ITGB1 antibody  >1 publications with CD63 and ITGB1
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with anti-CD63 antibodyOrgans/Tissues associated with anti-CD63 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >279 publications with CD63 and Immune System Diseases
 Neoplasms Antibodies  >172 publications with CD63 and Neoplasms
 Cardiovascular Diseases Antibodies  >151 publications with CD63 and Cardiovascular Diseases
 Inflammation Antibodies  >108 publications with CD63 and Inflammation
 Heart Diseases Antibodies  >51 publications with CD63 and Heart Diseases
 Nervous System Diseases Antibodies  >50 publications with CD63 and Nervous System Diseases
 Carcinoma Antibodies  >44 publications with CD63 and Carcinoma
 Necrosis Antibodies  >37 publications with CD63 and Necrosis
 Kidney Diseases Antibodies  >24 publications with CD63 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >23 publications with CD63 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >905 publications with CD63 and Blood
 Skin Antibodies  >153 publications with CD63 and Skin
 Vascular Antibodies  >120 publications with CD63 and Vascular
 Bone Antibodies  >59 publications with CD63 and Bone
 Lung Antibodies  >58 publications with CD63 and Lung
 Bone Marrow Antibodies  >46 publications with CD63 and Bone Marrow
 Kidney Antibodies  >45 publications with CD63 and Kidney
 Heart Antibodies  >38 publications with CD63 and Heart
 Brain Antibodies  >36 publications with CD63 and Brain
 Muscle Antibodies  >35 publications with CD63 and Muscle
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