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anti-CD66e antibody :: Mouse CD66e Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215175
Testing Data
Unit / Price
0.025 mg  /  $140 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD66e, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD66e

 Product Gene Name   

anti-CD66e antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114890
 3D Structure    ModBase 3D Structure for P06731
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    C365D3(NCRC23)
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Fusion Partners    Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3NSI myeloma cell line.
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. This product is photosensitive and should be protected from the light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD66e antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD66e antibody

   Mouse anti Human CD66e antibody, clone C365D3 (NCRC23) recognizes human Carcinoembryonic antigen-related cell adhesion molecule 5, also known as CD66e, carcinoembryonic antigen, Meconium antigen 100, CEA or CEACAM5. CD66e is a 702 amino acid ~77 kDa GPI anchored membrane protein containing 7 Ig-like domains. Mouse anti Human CD66e antibody, clone C365D3 does not cross-react with normal cross-reacting antigen (CD66c), or with biliary g lycoprotein (CD66a) as indicated by binding assays (Price 1988, note: in this study Mouse anti Human CD66e antibody, clone C365D3 is designated as clone 6 (from author)).
 Applications Tested/Suitable for anti-CD66e antibody   

Immunohistology Frozen, ELISA (EIA), Flow cytometry (FC/FACS), Immunohistology Paraffin*

 Application Notes for anti-CD66e antibody    Immunohistology - Frozen: Maximum Dilution: 1/1000;
Immunohistology - Paraffin: Maximum Dilution: 1/1000; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
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 Testing Data of anti-CD66e antibody    Published customer image: Immunostaining and cell surface expression of epithelial/pancreatic markers and overexpressed proteins in PaCa 5061 cells. 2A. The formaldehyde fixed and agar embedded cells were immunostained for the presence of pancreatic cancer markers CA 19-9 and CEA respectively, as well as for cytokeratin as epithelial cell marker proteins (upper panel). Several on RNA-level overexpressed genes (Microarray) were chosen. To confirm protein overexpression of selected amplified genes in PaCa 5061 cells immunostaining was performed for Mucin4, EGFR and CEACAM 6 (lower panel). 2B. FACS profiles of PaCa 5061 cells. Cell surface expression of CD44, EpCAM, EGFR, CEACAM1, CEACAM5 and CEACAM6 were obtained with specific antibodies as in materials and methods. Each histogram shows cell surface expression of the corresponding marker (filled curves) and the irrelevant, isotype-matched antibody (open curves). From: Kalinina T, GngÂr C, Thieltges S, MÂller-Krull M, Penas EM, Wicklein D, Streichert T, Schumacher U, Kalinin V, Simon R, Otto B, Dierlamm J, Schwarzenbach H, Effenberger KE, Bockhorn M, Izbicki JR, Yekebas EF. Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung. BMC Cancer. 2010 Jun 16;10:295.
anti-CD66e antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD66e. It may not necessarily be applicable to this product.
 NCBI GI #    612407802
 NCBI GeneID    1048
 NCBI Accession #    NP_001278413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291484.1 [Other Products]
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 UniProt Primary Accession #    P06731 [Other Products]
 UniProt Secondary Accession #    H9KVA7 [Other Products]
 UniProt Related Accession #    P06731 [Other Products]
 Molecular Weight    76,724 Da
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 NCBI Official Full Name    carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein
 NCBI Official Synonym Full Names    carcinoembryonic antigen-related cell adhesion molecule 5
 NCBI Official Symbol    CEACAM5 [Similar Products]
 NCBI Official Synonym Symbols   
CEA; CD66e
[Similar Products]
 NCBI Protein Information    carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
 UniProt Protein Name    Carcinoembryonic antigen-related cell adhesion molecule 5
 UniProt Synonym Protein Names   
Carcinoembryonic antigen; CEA; Meconium antigen 100; CD_antigen: CD66e
 UniProt Gene Name    CEACAM5 [Similar Products]
 UniProt Synonym Gene Names    CEA; CEA [Similar Products]
 UniProt Entry Name    CEAM5_HUMAN
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 NCBI Summary for CD66e    Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
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 UniProt Comments for CD66e    CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.

Protein type: Membrane protein, GPI anchor; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: integral to plasma membrane; basolateral plasma membrane

Molecular Function: identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis
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 Research Articles on CD66e    1. LOX with CEA, CA724, CA199, and CA125 could increase the sensitivity of predicting lymph nodes metastasis and peritoneal metastasis in gastric cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD66e antibodyDiseases associated with anti-CD66e antibody
 Reference Product  PubMed Publications
 CEACAM6 antibody  >115 publications with CD66e and CEACAM6
 HNRNPM antibody  >3 publications with CD66e and HNRNPM
 RAB11A antibody  >1 publications with CD66e and RAB11A
 VPS33B antibody  >1 publications with CD66e and VPS33B
 VIPAR antibody  >1 publications with CD66e and VIPAR
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >8400 publications with CD66e and Carcinoma
 Adenocarcinoma Antibodies  >4813 publications with CD66e and Adenocarcinoma
 Liver Neoplasms Antibodies  >2582 publications with CD66e and Liver Neoplasms
 Lung Neoplasms Antibodies  >2212 publications with CD66e and Lung Neoplasms
 Liver Diseases Antibodies  >1961 publications with CD66e and Liver Diseases
 Lung Diseases Antibodies  >1932 publications with CD66e and Lung Diseases
 Breast Neoplasms Antibodies  >1689 publications with CD66e and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1070 publications with CD66e and Carcinoma, Squamous Cell
 Ovarian Neoplasms Antibodies  >833 publications with CD66e and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >675 publications with CD66e and Neoplasms, Experimental
Organs/Tissues associated with anti-CD66e antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2405 publications with CD66e and Lung
 Stomach Antibodies  >1307 publications with CD66e and Stomach
 Thyroid Antibodies  >718 publications with CD66e and Thyroid
 Intestine Antibodies  >707 publications with CD66e and Intestine
 Pancreas Antibodies  >601 publications with CD66e and Pancreas
 Kidney Antibodies  >349 publications with CD66e and Kidney
 Ovary Antibodies  >341 publications with CD66e and Ovary
 Muscle Antibodies  >298 publications with CD66e and Muscle
 Brain Antibodies  >292 publications with CD66e and Brain
 Cervix Antibodies  >260 publications with CD66e and Cervix
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