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anti-CD68 antibody :: Mouse anti-Primate, Rat CD68 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS224643
Unit / Price
0.2 mg  /  $430 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD68, Monoclonal Antibody

★Popular Item★
 Also Known As   


 Product Gene Name   

anti-CD68 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153634
 3D Structure    ModBase 3D Structure for P34810
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    KP1
 Host    Mouse
 Species Reactivity    Primate, Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD68 antibody

   Mouse anti human CD68 antibody, clone KP1 recognises the human CD68 cell surface antigen, a 110kD glycoprotein primarily expressed by macrophages and monocytes.
 Applications Tested/Suitable for anti-CD68 antibody   

Flow cytometry (FC/FACS)*, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-CD68 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Application Note: Membrane permeabilisation is required for this application. MyBioSource recommends the use of Leucoperm for this purpose.
The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR.

Immunohistology - Paraffin: Application Note: This antibody requires heat-mediated antigen retrieval prior to staining paraffin sections. Citrate buffer, pH6.0, is recommended for this purpose.
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 Testing Data #1 of anti-CD68 antibody    Citrate pretreated human tonsil stained with Mouse anti Human CD68 (MBS224643) followed by Goat anti Mouse IgG:HRP
anti-CD68 antibody Testing Data #1 image
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 Testing Data #2 of anti-CD68 antibody    Human peripheral blood granulocytes stained with Mouse anti Human CD68:FITC (MBS224727)
anti-CD68 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CD68. It may not necessarily be applicable to this product.
 NCBI GI #    91199550
 NCBI GeneID    968
 NCBI Accession #    NP_001035148.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040059.1 [Other Products]
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 UniProt Primary Accession #    P34810 [Other Products]
 UniProt Secondary Accession #    Q53HR6; Q53XI3; Q96BI7; B4DVT4 [Other Products]
 UniProt Related Accession #    P34810 [Other Products]
 Molecular Weight    34,654 Da
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 NCBI Official Full Name    macrosialin isoform B
 NCBI Official Synonym Full Names    CD68 molecule
 NCBI Official Symbol    CD68 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1
 UniProt Protein Name    Macrosialin
 UniProt Synonym Protein Names   
Gp110; CD_antigen: CD68
 Protein Family    Macrosialin
 UniProt Gene Name    CD68 [Similar Products]
 UniProt Entry Name    CD68_HUMAN
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 NCBI Summary for CD68    This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD68    CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: membrane; lysosomal membrane; integral to membrane; plasma membrane; endosome membrane
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 Research Articles on CD68    1. CD68 tumor-associated macrophage marker is not prognostic of clinical outcome in classical Hodgkin lymphoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD68 antibodyPathways associated with anti-CD68 antibody
 Reference Product  PubMed Publications
 CD163 antibody  >402 publications with CD68 and CD163
 CSF1R antibody  >75 publications with CD68 and CSF1R
 TYROBP antibody  >3 publications with CD68 and TYROBP
 PSMD7 antibody  >1 publications with CD68 and PSMD7
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
Diseases associated with anti-CD68 antibodyOrgans/Tissues associated with anti-CD68 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1681 publications with CD68 and Inflammation
 Nervous System Diseases Antibodies  >1021 publications with CD68 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >936 publications with CD68 and Cardiovascular Diseases
 Necrosis Antibodies  >906 publications with CD68 and Necrosis
 Fibrosis Antibodies  >487 publications with CD68 and Fibrosis
 Disease Models, Animal Antibodies  >468 publications with CD68 and Disease Models, Animal
 Lung Diseases Antibodies  >453 publications with CD68 and Lung Diseases
 Kidney Diseases Antibodies  >379 publications with CD68 and Kidney Diseases
 Atherosclerosis Antibodies  >353 publications with CD68 and Atherosclerosis
 Liver Diseases Antibodies  >311 publications with CD68 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2842 publications with CD68 and Blood
 Vascular Antibodies  >1380 publications with CD68 and Vascular
 Muscle Antibodies  >1075 publications with CD68 and Muscle
 Skin Antibodies  >916 publications with CD68 and Skin
 Bone Antibodies  >864 publications with CD68 and Bone
 Brain Antibodies  >817 publications with CD68 and Brain
 Lymph Node Antibodies  >547 publications with CD68 and Lymph Node
 Liver Antibodies  >541 publications with CD68 and Liver
 Lung Antibodies  >509 publications with CD68 and Lung
 Kidney Antibodies  >502 publications with CD68 and Kidney
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