View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Rat anti-Mouse CD71 Monoclonal Antibody Catalog # MBS673434 Unit / Price 0.5 mg / $315 +1 FREE 8GB USB 5x0.5 mg / $1,240 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name CD71, Monoclonal Antibody Popular Item Full Product Name Rat Anti-Mouse CD71-UNLB Product Synonym Names Rat Anti-Mouse CD71 - Purified, Unlabeled Antibody; Rat Anti-Mouse CD71 Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype Rat IgG2a kappa Clone Number RI7217 Host Rat Species Reactivity Mouse Specificity CD71/transferrin receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions)CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells.^1, 4 It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation.^4 Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.^2 Form/Format Purified (UNLB) Antibody Characterization To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert. Preparation and Storage The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C. The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze! The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C. Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed. Other Notes Small volumes of anti-CD71 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for anti-CD71 antibody Flow Cytometry; Immunoprecipitation Application Notes for anti-CD71 antibody Research Application(s): In vivo and vitro inhibition of cell proliferation TOP Product References and Citations for anti-CD71 antibody 1. Lesley, J., R. Hyman, R. Schulte, and J. Trotter. 1984. Cell Immunol. 83:14.2. Kemp, J. D., J. A. Thorson, F. Gomez, K. M. Smith, J. S. Cowdery, and Z. K. Ballas. 1989. Cell Immunol. 122:218.3. Lesley, J.F., and R.J. Schulte. 1985. Mol. Cell. Biol. 5:1814.4. Kemp, J. D., J. A. Thorson, T. H. McAlmont, M. Horowitz, J. S. Cowdery, and Z. K. Ballas. 1987. J. Immunol. 138:2422.5. Sauvage, C.A., J.C. Mendelsohn, J.F. Lesley, and I.S. Trowbridge. 1987. Cancer Res. 47:747. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP