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anti-CD75s antibody :: Mouse CD75s Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219339 anti-CD75s antibody
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD75s, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CD75s

 Product Gene Name   

anti-CD75s antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109675
 3D Structure    ModBase 3D Structure for P15907
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    LN-1
 Host    Mouse
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 Form/Format    Purified
Purified IgM - liquid
 Concentration    IgM concentration 0.1mg/ml (lot specific)
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 Perservative Stabilisers    0.05% Sodium Azide
 Immunogen    Human lymphocytes and SU-DHL4 cell line
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD75s antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD75s antibody

   Mouse anti Human CD75s antibody, clone LN-1 recognizes the human CD75s cell surface antigen, an alpha2,6 - sialylated carbohydrate epitope expressed by mature B cells (especially germinal centre B cells), red blood cells and some epithelial cells.
 Applications Tested/Suitable for anti-CD75s antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunohistology Paraffin*

 Application Notes for anti-CD75s antibody    Immunohistology - Frozen: Minimum Dilution: 1/10; Maximum Dilution: 1/100;
Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
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NCBI/Uniprot data below describe general gene information for CD75s. It may not necessarily be applicable to this product.
 NCBI GI #    4506949
 NCBI GeneID    6480
 NCBI Accession #    NP_003023.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003032.2 [Other Products]
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 UniProt Primary Accession #    P15907 [Other Products]
 UniProt Secondary Accession #    A8KA14; B2R513; D3DNV3 [Other Products]
 UniProt Related Accession #    P15907 [Other Products]
 Molecular Weight    20,764 Da
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 NCBI Official Full Name    beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
 NCBI Official Synonym Full Names    ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 NCBI Official Symbol    ST6GAL1 [Similar Products]
 NCBI Official Synonym Symbols   
ST6N; SIAT1; ST6GalI
[Similar Products]
 NCBI Protein Information    beta-galactoside alpha-2,6-sialyltransferase 1; B-cell antigen CD75; CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; alpha 2,6-ST 1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)
 UniProt Protein Name    Beta-galactoside alpha-2,6-sialyltransferase 1
 UniProt Synonym Protein Names   
B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1
 UniProt Gene Name    ST6GAL1 [Similar Products]
 UniProt Synonym Gene Names    SIAT1; Alpha 2,6-ST 1; ST6GalI [Similar Products]
 UniProt Entry Name    SIAT1_HUMAN
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 NCBI Summary for CD75s    This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]
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 UniProt Comments for CD75s    SIAT1: a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found.

Protein type: Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.99.1; Transferase

Chromosomal Location of Human Ortholog: 3q27.3

Cellular Component: Golgi membrane; integral to Golgi membrane

Molecular Function: sialyltransferase activity; beta-galactoside alpha-2,6-sialyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; O-glycan processing; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; humoral immune response; N-acetylneuraminate metabolic process
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 Research Articles on CD75s    1. ST6GAL1 promotes TGF-beta-dependent epithelial-mesenchymal transition
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD75s antibodyPathways associated with anti-CD75s antibody
 Reference Product  PubMed Publications
 B4GALT1 antibody  >3 publications with CD75s and B4GALT1
 MUC7 antibody  >1 publications with CD75s and MUC7
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway antibodies  Defective ALG1 Causes ALG1-CDG (CDG-1k) Pathway Diagram
 Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway antibodies  Defective ALG11 Causes ALG11-CDG (CDG-1p) Pathway Diagram
 Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway antibodies  Defective ALG12 Causes ALG12-CDG (CDG-1g) Pathway Diagram
 Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway antibodies  Defective ALG14 Causes Congenital Myasthenic Syndrome (ALG14-CMS) Pathway Diagram
 Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway antibodies  Defective ALG2 Causes ALG2-CDG (CDG-1i) Pathway Diagram
 Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway antibodies  Defective ALG3 Causes ALG3-CDG (CDG-1d) Pathway Diagram
 Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway antibodies  Defective ALG6 Causes ALG6-CDG (CDG-1c) Pathway Diagram
 Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway antibodies  Defective ALG8 Causes ALG8-CDG (CDG-1h) Pathway Diagram
Diseases associated with anti-CD75s antibodyOrgans/Tissues associated with anti-CD75s antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >11 publications with CD75s and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with CD75s and Liver Neoplasms
 Inflammation Antibodies  >6 publications with CD75s and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with CD75s and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >4 publications with CD75s and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with CD75s and Cell Transformation, Neoplastic
 Diabetes Mellitus, Type 2 Antibodies  >3 publications with CD75s and Diabetes Mellitus, Type 2
 Hyperplasia Antibodies  >2 publications with CD75s and Hyperplasia
 Lung Neoplasms Antibodies  >2 publications with CD75s and Lung Neoplasms
 Disease Models, Animal Antibodies  >2 publications with CD75s and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >33 publications with CD75s and Blood
 Liver Antibodies  >16 publications with CD75s and Liver
 Lymph Antibodies  >9 publications with CD75s and Lymph
 Lymph Node Antibodies  >9 publications with CD75s and Lymph Node
 Lung Antibodies  >8 publications with CD75s and Lung
 Vascular Antibodies  >6 publications with CD75s and Vascular
 Stomach Antibodies  >6 publications with CD75s and Stomach
 Bone Antibodies  >5 publications with CD75s and Bone
 Brain Antibodies  >5 publications with CD75s and Brain
 Skin Antibodies  >4 publications with CD75s and Skin
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